Giant Condyloma Acuminatum (Buschke-Löwenstein Tumor) of the Rectum

Knoblich, Roman; Failing, John F.

doi:10.1093/ajcp/48.4.389

Cited by 80 publications

(19 citation statements)

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“…[11]. Obwohl der blumenkohlf/3rmige Tumor klinisch ein malignes Wachstum zeigt, erftillt er nicht die histomorphologischen Kriterien der Malignit~it.…”

Section: Zusammenfassung Das Riesenkondylom In Anorektalerunclassified

Invasive squamous-cell carcinoma in giant anorectal condyloma (Buschke-L�wenstein tumor)

Bertram

Treutner

Rübben³

et al. 1995

Langenbecks Arch Chir

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Giant condyloma acuminata, first described by Buschke and Löwenstein in 1925 as a penile lesion, is extremely rare in the anorectal region. The cauliflower-like tumor behaves clinically in a malignant fashion, although it shows no histomorphological criteria of malignancy. Up to the time of writing only 33 cases of anorectal origin, 42% with malignant transformation, have been published. The authors report 2 more cases of squamous-cell carcinoma in giant anorectal condylomata acuminata. Buschke-Löwenstein tumor is an intermediate entity between "ordinary" condyloma acuminata and squamous-cell carcinoma. Benign condyloma acuminata is caused by human papillomavirus 6 or 11. Carcinogenic cofactors promote the transition to giant, locally destructive condyloma acuminata and subsequent malignant transformation. Cure can only be achieved by early and radical excision. Formation of multiple fistulas and destruction of the sphincter may necessitate abdomino-perineal resection. Adjuvant radiation therapy should only be considered to render a tumor operable, as radiation may act as a cocarcinogenic effect and lead to a less differentiated and more aggressive cancer. The small number of cases reported and the variety of treatment regimens applied, however, do not allow the formulation of definitive therapeutic guidelines.

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“…[11]. Obwohl der blumenkohlf/3rmige Tumor klinisch ein malignes Wachstum zeigt, erftillt er nicht die histomorphologischen Kriterien der Malignit~it.…”

Section: Zusammenfassung Das Riesenkondylom In Anorektalerunclassified

Invasive squamous-cell carcinoma in giant anorectal condyloma (Buschke-L�wenstein tumor)

Bertram

Treutner

Rübben³

et al. 1995

Langenbecks Arch Chir

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“…The Buschke-Lowenstein tumor is a large, painful, exophytic cauliflower-like rare lesion which also grows in an endophytic fashion. Since its first description by Buschke [2] as condyloma of the phimotic foreskin several reports have indicated that it can also occur on the oral mucosa, vulva and cervix [5][6][7], However BLT of the anorectal location is rarer; including our case only thirty-two giant condylomata acuminata of the anorectum have been reported since its first descrip tion in that location [6,7,[9][10][11] (table 1).…”

Section: Discussionmentioning

confidence: 78%

Buschke-Löwenstein Tumor of the Anal Region

Ulualp¹,

Aydemir²,

Eyüboğlu³

et al. 1993

Dig Surg

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Giant invasive condyloma acuminatum, also known as Buschke-Löwenstein tumor, is a human papilloma virus (HPV) type 6 or 10-associated lesion which is rarely seen in the anorectum. These lesions despite their histologic benignity are clinically malignant with a propensity for recurrence and invasion. The aggressive character of this lesion and its likelihood of malignant transformation together with the associated significant mortality require early surgical excision with clear margins. Authors report on a patient with giant perianal condyloma acuminatum who was treated in a single session by total excision and fasciocutaneous VY advancement flap.

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“…The most common site for this tumor is on the glans penis; however, it can also be found on any anogenital mucosal surface like vulva, vagina, and rectum. Histologically, GCA exhibits features of pseudoepitheliomatous proliferation and local invasion by massive epidermal hyperplasia, hyperkeratosis, and parakeratosis; it is also markedly exophytic [9]. …”

Section: Discussionmentioning

confidence: 99%

Giant Condyloma Acuminatum of Vulva in an HIV-Infected Woman

Lilungulu

Mpondo

Mlwati

et al. 2017

Case Reports in Infectious Diseases

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First described in 1925, giant condyloma acuminatum also known as Buschke-Löwenstein tumor (BLT) is a benign, slow-growing, locally destructive cauliflower-like lesion usually in the genital region. The disease is usually locally aggressive and destructive with a potential for malignant transformation. The causative organism is human papilloma virus. The most common risk factor is immunosuppression with HIV; however, any other cause of immunodeficiency can be a predisposing factor. We present a case of 33-year-old female patient, a known HIV patient on antiretroviral therapy for ten months. She presented with seven-month history of an abnormal growth in the genitalia that was progressive accompanied with foul smelling yellowish discharge and friable. Surgical excision was performed successfully. Pap smear of the excised tissue was negative. Despite being a rare condition, giant condyloma acuminatum is relatively common in HIV-infected patients.

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Giant Condyloma Acuminatum (Buschke-Löwenstein Tumor) of the Rectum

Cited by 80 publications

References 0 publications

Invasive squamous-cell carcinoma in giant anorectal condyloma (Buschke-L�wenstein tumor)

Invasive squamous-cell carcinoma in giant anorectal condyloma (Buschke-L�wenstein tumor)

Buschke-Löwenstein Tumor of the Anal Region

Giant Condyloma Acuminatum of Vulva in an HIV-Infected Woman

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