Giant Condyloma Acuminatum

Ergün, Selma Sönmez; Kural, Yasemin Balsever; Büyükbabanı, Nesimi; Verim, Levent; Akbulut, Habib; Gurkan, Levent

doi:10.1046/j.1524-4725.2003.29067.x

Cited by 16 publications

(20 citation statements)

References 17 publications

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“…aggressive local growth by compression, destruction and infiltration of neighbouring tissues and lack of spontaneous resolution. 1,3,4 This behaviour conflicts with its benign histological features. In addition, GCA has a high propensity for local recurrence and considerable risk of neoplastic transformation into fully invasive squamous cell carcinoma (SCC).…”

mentioning

confidence: 98%

“…An initial surgical approach is recommended for complete elimination of the tumour and prevention of recurrence. [1][2][3][4][7][8][9] The extent of surgical excision is determined by the size of the lesion and the degree of penetration to adjacent structures. 8 Penectomy may be required in extensive penile involvement, with abdominoperineal resection and reconstruction of a new penis with free flap phalloplasty.…”

mentioning

confidence: 99%

“…1,5,7,8 Topical podophyllin 25-30% or 5-fluororacil (5-FU) are futile in eradicating GCA. 1,2,4,7,8 Although successful preliminary reports of HPV vaccination have brought optimism for the future, immunotherapy still remains an investigational therapeutic tool. 1,10 Intralesional or systemic interferon-a2b may be effective in GCA because of its immunomodulating, antiproliferative and antiviral properties.…”

mentioning

confidence: 99%

“…1,3,5 Radiotherapy should be reserved for nonresectable or adamantly recurrent lesions, as it may increase the risk of anaplastic transformation. 2,4,9 Systemic chemotherapy with methotrexate, 5-FU, bleomycin, mitomycin C, cisplatin, and leucovorin may be tried in extensive or recurrent GCA. 3,4,9 Alternative methods include cryotherapy, laser and electrocauterization.…”

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confidence: 99%

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Giant condyloma acuminata of Buschke-Löwenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod

Erkek

Başar²,

Bozdoğan³

et al. 2009

Clinical and Experimental Dermatology

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Human papillomavirus (HPV) is the most common sexually transmitted disorder in young, sexually active populations in the USA and Europe. Giant condyloma acuminatum (GCA) is a unique variant of condyloma acuminata, characterized by local aggressive behaviour despite benign histology. It carries a substantial risk of squamous cell carcinoma. Various treatments have been used, but response is often poor and recurrence rates high. We present a case of GCA successfully treated with a combination of surgical excision, oral acitretin and topical imiquimod. The diagnosis was based on histological examination, immunohistochemical analysis and in situ hybridization for HPV 6 and 11. We recommend a trial of oral retinoid and topical imiquimod in selected cases of GCA.

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confidence: 98%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Giant condyloma acuminata of Buschke-Löwenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod

Erkek

Başar²,

Bozdoğan³

et al. 2009

Clinical and Experimental Dermatology

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“…Puede afectar a vulva, vagina, recto, escroto, pene, periné y vejiga 1,2 . Aunque se trata de una lesión benigna, que no produce metástasis a distancia, se puede considerar precursora del carcinoma verrucoso.…”

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Colostomía previa a escisión quirúrgica de un tumor de Buschke-Löwenteim en la infancia

Criado

Jiménez

et al. 2012

Rev Chil Cir

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Temporary colostomy before surgery in Buschke-Löwenteim tumour in childrenBuschke-Löwentein tumor is a verrucous lesion, with slow growth and locally infi ltrating. Despite her benign histology, is an intermediate lesion between condiloma acuminatum and verrucous carcinoma. It has been linked to human papilloma virus (subtypes 6 and 11). Other factors implicated include poor hygiene, chronic irritation, promiscuity and cellular inmunocompromised states. It is exceptional in children. We report a case of a 6-year-old girl with HIV infection B3 and giant condyloma that affect genitoanal region and rectal mucosa. The temporary colostomy aimed good results of the surgical excision.Key words: Buschke-Löwentein tumor, colostomy, human papilloma virus, inmunocompromised. ResumenEl tumor de Buschke-Löwentein es una lesión verrucosa, con crecimiento lento, y localmente infi ltrante. A pesar de su histología benigna, se trata de una lesión intermedia entre el condiloma acuminado y el carcinoma verrucoso. Su aparición está ligada con el virus del papiloma humano (subtipos 6 y 11). Otros factores que intervienen son la baja higiene, promiscuidad, irritación crónica y la inmunosupresión celular. Es excepcional su aparición en niños. La exéresis quirúrgica radical es el tratamiento de elección. La realización de una colostomía de descarga previa, permite el aislamiento, facilitando la cicatrización de la zona y evitando el contacto con material fecal que contribuye a la recidiva. Presentamos un caso de una niña de 6 años con VIH estadio B3 y condilomatosis gigante que afectaba a la región genitoanal y a la mucosa rectal adyacente. La colostomía temporal contribuyó al éxito tras la resección quirúrgica.Palabras clave: Tumor de Buschke-Löwentein, colostomía, virus del papiloma humano, inmunodeficiencia.

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Giant condylomata accuminata of scrotum representing as carcinoma (a case report)

et al. 2006

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Giant Condyloma Acuminatum

Abstract: This case is an interesting case because of its exceptionally huge size without any deep tissue involvement and tissue atypia. This suggests that giant condyloma is an intermediate condition that exhibits a continuous tendency for growth.

Cited by 16 publications

References 17 publications

Giant condyloma acuminata of Buschke-Löwenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod

Giant condyloma acuminata of Buschke-Löwenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod

Colostomía previa a escisión quirúrgica de un tumor de Buschke-Löwenteim en la infancia

Giant condylomata accuminata of scrotum representing as carcinoma (a case report)

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