Giant Congenital Nevus and Malignant Melanoma

Hori, Yoshiaki; Nakayama, Juichiro; Okamoto, Mitsuse; Nagae, Shonosuke; Taniguchi, Shun’ichiro; Takayama, Osami; Oohara, Kuniaki

doi:10.1038/jid.1989.88

Cited by 28 publications

(11 citation statements)

References 18 publications

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“…To our knowledge, there are reports of only two cases that document the development of malignant melanoma after dermabrasion of a giant nevus in childhood. In these cases, the time between dermabrasion and diagnosis of the malignant melanoma was only a few months 8,9 …”

Section: Discussionmentioning

confidence: 96%

Multicentric Malignant Melanoma in a Giant Melanocytic Congenital Nevus 20 Years After Dermabrasion in Adulthood

et al. 2003

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Section: Discussionmentioning

confidence: 96%

Multicentric Malignant Melanoma in a Giant Melanocytic Congenital Nevus 20 Years After Dermabrasion in Adulthood

et al. 2003

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“…6 The 5-year cumulative table risk for developing malignant melanoma is 2.3% to 5.7%. 11,13,14 Other reported malignancies include liposarcoma, rhabdomyosarcoma, malignant peripheral nerve sheath tumour and neurocutaneous melanosis. 7,11,12,15 Malignant melanoma (MM) is a relatively common neoplasm arising from melanocytes.…”

Section: Discussionmentioning

confidence: 99%

Malignant transformation in Pre-existing Naevi. A review of two cases

Samaila¹,

Adesiyun²

2010

Nigerian Journal of Surgical Research

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Pigmented naevi (melanocytic naevi) are common and are widely distributed all over the body. The average number of naevi seen in a Caucasian is between twenty and thirty. They are either congenital or acquired benign neoplasm of melanocytes. They may occur as giant lesions at birth, and are more prone to malignant transformation. However, the risk of malignant transformation associated with naevi irrespective of size is well established and a variety of malignancies have been reported to arise from a naevus. The incidence of malignant transformation in naevi is 4% to 9%. We present two cases of malignant tumours arising from pre-existing naevus. The first was a 60-year old woman with a malignant melanoma arising in a vulva intradermal naevus. The second was a 51-year old woman with a basal cell carcinoma arising in a facial naevus. IntroductionPigmented naevus (melanocytic naevi) is the commonest tumour in the entire category of neoplastic diseases. [1][2][3][4] The frequency of its occurrence lulls suspicion and hence favours tolerance by patients and physicians alike. 3 The time of appearance of naevi is variable and seems related to exposure to melanin provoking influence.

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“…Da kleine kongenitale Naevi 10-bis 20-mal häufiger sind als große und auch wesentlich häufiger multipel auftreten,ist deren malignes Potenzial insgesamt von größerer praktischer Bedeutung als das der großen Exemplare [14,20]. Die Transformation in ein Melanom findet bei kleineren Naevi jedoch in deutlich späteren Lebensabschnitten statt als bei größeren, so dass hier die prophylaktische Exzision für die Pubertätszeit nahegelegt wird [7,9,12,14].…”

Section: Introductionunclassified

“…Diese sollte bereits in den ersten Lebenswo- chen durchgeführt werden, weil bei diesem Naevustyp die Gefahr der Melanomentstehung bereits in früher Kindheit besteht [9,12,18].Außerdem sind bei entsprechend großflächigen Naevi oft Serienexzisionen über Jahre notwendig, in deren Verlauf das Melanomrisiko erhalten bleibt [9]. Bei sehr großen Naevi empfiehlt sich eine Dermabrasio.…”

Section: Introductionunclassified

Melanom auf kongenitalem Naevus

Gaube

Paul

2002

Hautarzt

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Giant congenital nevi involve an approximately 5% risk of malignant transformation. We report about a 27-year-old patient who developed malignant melanoma after radiation of a large congenital nevus of the foot which was initially misinterpreted as a trophic disorder. The mechanisms and probability of malignant transformation and prophylactic therapy of large vs small congenital nevi are discussed.

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Giant Congenital Nevus and Malignant Melanoma

Cited by 28 publications

References 18 publications

Multicentric Malignant Melanoma in a Giant Melanocytic Congenital Nevus 20 Years After Dermabrasion in Adulthood

Multicentric Malignant Melanoma in a Giant Melanocytic Congenital Nevus 20 Years After Dermabrasion in Adulthood

Malignant transformation in Pre-existing Naevi. A review of two cases

Melanom auf kongenitalem Naevus

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