Giant coronary arterial aneurysms and thrombosis in an infant with Kawasaki disease

Abstract

after the onset of fever with signs and symptoms of Kawasaki disease. He was treated with intravenous immunoglobulin, heparin, and oral aspirin. His echocardiogram showed giant bilateral coronary arterial aneurysms with a moderate pericardial effusion. Three days later, there were also large thrombuses in both his right and left coronary arteries, as demonstrated on this parasternal short axis echocardiographic view at the level of the aorta ( Figure; Abbreviations: Ao ϭ aorta; LCA ϭ main stem of left coronary artery; RCA ϭ right coronary artery; RV ϭ right ventricle). Giant aneurysms of the left (12 millimetres) and right (6.5 millimetres) coronary arteries are seen, with a large thrombus (delineated by horizontal arrowheads) within the lumen of the left anterior interventricular coronary artery. A moving image showing the salient features is posted on the website at

Giant coronary artery aneurysms complicating Kawasaki disease in Mexican children

“…We found that thrombocytosis and hypoalbuminaemia were two factors found in patients with giant coronary aneurysms compared with patients without them. These two findings were also not previously reported 22 23 …”

“…These two findings were also not previously reported. 22,23 Some extracoronary echocardiographic findings, such as myocarditis, pericardial effusion, pericarditis, and hypokinesia, were significantly associated with the development of giant coronary aneurysms and were associated with persistent and severe myocardial inflammation. A similar finding had been reported by Lega et al, 24 who found that children with coronary artery lesions were more likely to have pericardial effusion or mitral regurgitation during the acute phase of the disease; however, this association was reported for coronary artery lesions and not specifically for giant coronary aneurysms.…”

A maternal high-fat diet during pregnancy and lactation, in addition to a postnatal high-fat diet, leads to metabolic syndrome with spatial learning and memory deficits: beneficial effects of resveratrol

“…The offspring of both sexes were weaned at 3 weeks of age, and onto either the normal diet or high-fat diet ad libitum from weaning to 4 months of age. Five experimental groups (n = 12-14 per group) were generated: control rat chow diet/postnatal rat chow diet (CC), maternal high-fat diet/postnatal rat chow diet (HC), control rat chow diet/postnatal high-fat diet (CH), and maternal high-fat diet/postnatal high-fat diet [ 73 ]. In addition, a therapeutic group with resveratrol on maternal high-fat diet/postnatal high-fat diet was raised for comparison (HHR).…”

Successful Revascularization of a Completely Occluded Right Coronary Artery by Local Thrombus Fragmentation, Thrombolysis, Thrombus Aspiration and Balloon Angioplasty in a Patient with Atypical Kawasaki Disease

“…However, in adult as well as pediatric patients with KD, limited experience with catheter interventions has been reported [4,7,8]. Options for coronary revascularization in KD generally consist of intravenous coronary thrombolysis, percutaneous coronary intervention, or coronary artery bypass grafting [9,10,11,12]. The guidelines for catheter interventions in KD, published by the research committee of the Japanese Ministry of Health, Labor, and Welfare, indicate that patients with acute myocardial infarction after KD can be candidates for percutaneous transluminal coronary revascularization and intravenous thrombolysis, patients with stenotic lesions with mild calcification can be candidates for percutaneous transluminal coronary balloon angioplasty (PCBA), and patients with severe calcifications can be candidates for rotational ablation [13].…”