Giant Cystic Pheochromocytoma Containing High Concentrations of Catecholamines and Metanephrines

Goldberg, Alyse S.; Pautler, Stephen E.; Harle, Christopher; Dennis, Alan; Rachinsky, Irina; Dhir, Achal; Boyle, Shawna L.; McAlister, Vivian C.; Uum, Stan Van

doi:10.1210/jc.2011-0465

Cited by 9 publications

(7 citation statements)

References 1 publication

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“…Certainly, this case is one of the largest ones discovered. The component of the cystic fluid in one reported case was found to have high concentrations of catecholamines and metanephrines 11. Clinically, this is important as these may circulate intravenously as the mass is isolated during surgical removal.…”

Section: Discussionmentioning

confidence: 87%

Giant cystic pheochromocytoma

Cajipe

González

Kaushik³

2017

BMJ Case Reports

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A 56-year-old healthy woman presents with 2-year history of symptoms classic for pheochromocytoma. Evaluation revealed one of the largest cystic pheochromocytomas reported but without any metastatic disease. After achieving medical management of her symptoms, surgical removal was performed successfully and without any complications intraoperatively. Pathology of the mass confirmed the diagnosis. The patient had complete resolution of her symptoms thereafter.

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Section: Discussionmentioning

confidence: 87%

Giant cystic pheochromocytoma

Cajipe

González

Kaushik³

2017

BMJ Case Reports

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“…One of the unusual features of the present case is the cystic components. Most of the time, pheochromocytoma is a solid neoplasm originating from the adrenal medulla ( 29 , 35 ), while cystic pheochromocytoma is a rare neuroendocrine tumor, with only a few described in former studies ( 5 , 18 , 19 , 21 , 22 , 25 , 29 , 31 ). Goldberg et al.…”

Section: Discussionmentioning

confidence: 99%

Case report: Significant liver atrophy due to giant cystic pheochromocytoma

Feng

Qiu

et al. 2022

Front. Oncol.

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IntroductionPheochromocytoma is a neuroendocrine tumor originating from chromaffin cells in the adrenal medulla. Giant pheochromocytomas with a maximum diameter of over 20 cm are particularly rare.Case presentationWe present a case of giant cystic pheochromocytoma in a 64-year-old woman who was found to have a right abdominal mass during an ultrasound examination, which is the largest pheochromocytoma ever documented in China. Meanwhile, obvious atrophy of the right lobe of the liver was found in preoperative CT and during the operation. Our literature review identified 20 cases with a diameter of over 20 cm. The average age at diagnosis was 51.7 (range 17–85), and 35% of cases did not exhibit classic symptoms.ConclusionGiant pheochromocytoma is an uncommon neoplasm. It can be discovered late due to a lack of clinical manifestations. Diagnosis is dependent on imaging recognition together with catecholamine secretion. Surgical resection is the only curative treatment for such tumors.

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“…Including both open and laparoscopic cases, a total of 33 cystic pheochromocytoma !10 cm had sufficient detail regarding perioperative outcomes for inclusion (including current case). Of all patients, 19 had a preoperative diagnosis [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] and 14 had no preoperative diagnosis. [28][29][30][31][32][33][34][35][36][37][38][39][40] A summary of characteristics of these two groups is shown in Table 3 and demonstrates a striking difference in number and severity of complications, suggesting that careful anaesthetic and surgical planning can have a positive impact on outcomes.…”

Section: Discussionmentioning

confidence: 99%

Incidental giant cystic pheochromocytoma: a case report and review of the literature

2020

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Introduction Pheochromocytoma is a tumour arising from the adrenal medulla, which secretes catecholamines. Approximately 20% of pheochromocytomas are cystic and more likely to be asymptomatic. They should be surgically resected as all have a malignant potential and pose cardiovascular risk. Case presentation: We report the case of a 61-year-old female patient admitted electively for laparoscopic adrenalectomy for a large cystic pheochromocytoma detected incidentally. Diagnosis was confirmed preoperatively by elevated 24-h urinary metanephrines. The patient was treated preoperatively with alpha and beta blockade. Surgery was without complication; she had an uneventful postoperative recovery and no evidence of recurrence at one-year follow-up. Conclusion This case highlights the necessity of investigating for biochemical function in all adrenal lesions by measuring metanephrines, even when entirely cystic on imaging. Given the surgical and anaesthetic risk in resection of pheochromocytoma, attaining a preoperative diagnosis allows for careful preoperative planning and safe surgery.

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Giant Cystic Pheochromocytoma Containing High Concentrations of Catecholamines and Metanephrines

Cited by 9 publications

References 1 publication

Giant cystic pheochromocytoma

Giant cystic pheochromocytoma

Case report: Significant liver atrophy due to giant cystic pheochromocytoma

Incidental giant cystic pheochromocytoma: a case report and review of the literature

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