Giant epidermoid cyst in the breast: A common benign lesion at a rare site—A case report

Mahmud, Mayin Uddin; Sheuly, Sayera Banu; Bhuiyan, Nur Hossain; Chowdhury, Rana; Ali, Ramjan

doi:10.1016/j.ijscr.2017.05.014

Cited by 8 publications

(14 citation statements)

References 8 publications

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“…Epidermal inclusion cysts have also been described by other terms, such as follicular infundibular cysts, epidermal cysts, and epidermoid cysts [5]. These cysts are commonly cutaneous or subcutaneous, and present in hairy body areas such as scalp, neck, and trunk [5–7]. They rarely occur in the breast; Menville et al reported the first case of epidermal inclusion cyst of the breast in 1900 [2,8].…”

Section: Discussionmentioning

confidence: 99%

“…Paliotta et al identified a total of 91 patients affected by epidermal inclusion cysts of the breast through a search of the literature in 2014 [2], and thereafter, sporadic case reports of epidermal inclusion cysts have been published until recently [7,9–15]. Epidermal inclusion cysts of the breast typically develop during the fifth decade of life [2], and are usually located in the skin; however, they can develop in unusual locations, such as cutaneously on the nipple or areola or intra-parenchymally in the subor peri-areolar regions.…”

Section: Discussionmentioning

confidence: 99%

“…A significant association has been observed between tumor size and malignancy transformation [2]. Specifically, when larger than 5 cm in diameter, epidermal inclusion cysts are classified as giant, which are rare and more likely to develop complications such as malignant transformation [7]. Paget’ s disease involving a subareolar epidermal inclusion cyst also has been reported in 1 case [18].…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Imaging Features of a Ruptured Epidermal Inclusion Cyst in the Subareolar Area: A Case Report

Kim

2019

Am J Case Rep

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Patient: Female, 58 Final Diagnosis: Epidermal inclusion cyst Symptoms: Bloody nipple discharge Medication: — Clinical Procedure: — Specialty: Radiology Objective: Rare disease Background: Epidermal inclusion cysts rarely develop in the breast. The cysts that do develop within the breast typically present as cutaneous or subcutaneous cysts. They more rarely present in a subareolar location or in a ruptured state. Thus far, 5 cases of ruptured epidermal inclusion cysts in subareolar locations have been reported in the English literature. Furthermore, clinical presentation of nipple discharge is rare in epidermal inclusion cysts of the breast; only 4 such cases has been reported. Case Report: A 58-year-old female presented with a 1-month history of bloody discharge from her left nipple. Mammography showed focal asymmetry in the left subareolar region; sonography showed a left subareolar mass with irregular shape, indistinct margin, heterogeneous echogenicity, and posterior enhancement. The mass was surgically excised; a pathological diagnosis of ruptured epidermal inclusion cyst with foreign body reaction and abscess formation was established. In this case, the clinical presentation of bloody nipple discharge was peculiar; furthermore, mammographic and sonographic features were indistinguishable from breast malignancy or typical breast abscess. Conclusions: A ruptured epidermal inclusion cyst can present in an unusual subareolar location, combined with bloody nipple discharge; importantly, this can radiologically resemble breast malignancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical and Imaging Features of a Ruptured Epidermal Inclusion Cyst in the Subareolar Area: A Case Report

Kim

2019

Am J Case Rep

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“…ECs, interchangeable with infundibular cysts and epidermal inclusion cysts, are benign superficial cystic masses that generally arise from the infundibulum of hair follicles within the dermis. [2] Histologically, they are walled-off cavities, lined by squamous epithelium and containing a granular layer [Figure 6a]. This granular layer is one of the three features that distinguish the EC from another entity known as pilar cysts (also known as a trichilemmal cyst).…”

Section: Discussionmentioning

confidence: 99%

“…[3,4] These features of EC represent the implantation or proliferation of superficial epidermal elements within the deeper dermis. [2,5] ECs are filled internally with orthokeratin material. [6] There are several proposed mechanisms for the growth of ECs.…”

Section: Discussionmentioning

confidence: 99%

Epidermoid Cyst in Male Patient Mimicking a Suspicious Breast Mass and Consequences of Biopsy

Rahman¹,

Shokouh-Amiri

Wiley

et al. 2019

JCIS

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Male patients presenting to the mammography department for workup of breast disease is an overall rare event compared to females. Gynecomastia is statistically the most common breast condition afflicting male patients, with ductal carcinoma an uncommon secondary diagnostic consideration. Secondary benign breast conditions or mimickers of breast disease in men are even rarer than primary carcinoma and can pose a significant challenge in breast imaging workups. We present a challenging workup of a superficial epidermoid cyst (EC) in a male patient with significant subcutaneous growth and indeterminate imaging characteristics, mimicking a breast neoplasm. Furthermore, we present undesirable consequences of performing a biopsy of an EC including rupture and abscess formation.

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Clinical and radiologic characteristics of ruptured epidermal inclusion cysts in the nipple and subareolar regions: A report of two cases

Fahed,

Ghazal

2024

Intl J Gynecology & Obste

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Epidermal inclusion cysts (EICs) in the breast, particularly in the nipple and subareolar regions, are rare entities that pose significant diagnostic challenges and management dilemmas in clinical practice. This study retrospectively analyzes two case reports of women presenting with EICs located in these unusual breast areas. The subjects included a 35‐year‐old female with congested nipple symptoms and bilateral mastodynia, and a 58‐year‐old female with a palpable right breast nodule. Diagnostic efforts involved magnetic resonance imaging (MRI), sonography, and mammography, which highlighted the cysts' onion‐like asymmetry and heterogeneous characteristics with posterior acoustic enhancement. Despite detailed imaging, distinguishing these cysts from malignancies or typical abscesses proved difficult. Both cases experienced spontaneous cyst rupture with subsequent resolution following antibiotic therapy. A literature review confirmed the rarity of such cases, emphasizing the importance of recognizing EICs to avoid unnecessary surgical interventions. These findings underscore the need for heightened clinical awareness and detailed imaging to accurately diagnose and manage EICs in atypical breast locations, and call for further research to explore their etiology and optimal treatment strategies.

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Giant epidermoid cyst in the breast: A common benign lesion at a rare site—A case report

Cited by 8 publications

References 8 publications

Clinical and Imaging Features of a Ruptured Epidermal Inclusion Cyst in the Subareolar Area: A Case Report

Clinical and Imaging Features of a Ruptured Epidermal Inclusion Cyst in the Subareolar Area: A Case Report

Epidermoid Cyst in Male Patient Mimicking a Suspicious Breast Mass and Consequences of Biopsy

Clinical and radiologic characteristics of ruptured epidermal inclusion cysts in the nipple and subareolar regions: A report of two cases

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