Giant extraocular sebaceous carcinoma: case report and a brief review of a literature

Giant sebaceous nevus occupying half of the head associated with sebaceous carcinoma, apocrine adenocarcinoma, and basal cell carcinoma: A case report

“… 3 Therefore, extensive resection is recommended in cases of highly invasive sebaceous adenocarcinoma, and surgical excision with wide margins should be the standard treatment. 4 A surgical resection margin of 10–30 mm was obtained in our case. If the defect is more extensive, not only skin grafting but also a tissue expander technique is often used for reconstruction in the head and neck region, which is essential after resection of large tumors (>20 cm) .…”

A Rare Case of a Giant Tumor of Sebaceous Glands in the Posterior Chest Wall

“…Sebaceous carcinoma is part of the group of Malignant Adnexal Tumors of the Skin (MATS) and it is a rare and aggressive tumor that accounts for less than 1% of all cutaneous tumors, but even despite that, it is the most common type among cutaneous adnexal tumors [3,7,[12][13].…”

“…In the histopathological examination, the use of conventional hematoxylin and eosin staining may show positivity for the tumor of sebaceous glands, but the confirmation is made through the immunohistochemical analysis with the use of markers such as EMA (epithelial membrane antigen), BER-EP4, CA15.3, androgen receptor, and adipophilin [1,3,7]. A characteristic of this type of tumor is the negative result for CEA (Carcinoembryonic Antigen) [2].…”

“…Sebaceous carcinoma is a rare and aggressive skin cancer that originates from the adnexal epithelium of the sebaceous gland and corresponds to 0.2% to 4.6% of all cutaneous malignant tumors [1][2][3][4][5][6]. Although it can be found in any part of the body that has sebaceous glands, the periorbital region is the most affected (75%) [1,4,5,7].…”

“…Extraocular sebaceous carcinoma accounts for only 25% of cases and may affect the head, neck, external genitalia, extremities and trunk [1,4,[7][8][9]. Without specific symptoms, the diagnosis is restricted to the immunohistochemical analysis, with the use of several markers, after biopsy or total resection of the lesion [1][2][3]5]. We present a case of carcinoma of sebaceous glands in the trunk, whose patient was slow to seek medical attention resulting in a giant tumor.…”