Giant fibroadenoma of the breast in adolescents

Gobbi, Dalia; Dall’Igna, Patrizia; Alaggio, Rita; Nitti, Donato; Cecchetto, Giovanni

doi:10.1016/j.jpedsurg.2008.11.041

Cited by 47 publications

(31 citation statements)

References 11 publications

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“…Fibroadenoma is the most common breast mass in the adolescent 1,2,3 . Giant or juvenile fibroadenoma accounts for 0.5-2 per cent of all cases of fibroadenomas 4 .…”

Section: Introductionmentioning

confidence: 99%

Giant fibroadenoma presenting like fungating breast cancer in a Nigerian teenager

Arowolo¹,

Akinkuolie²,

Adisa³

et al. 2013

Af Hlth Sci

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Background: Giant fibroadenoma of the breast is a rare benign breast tumour which seldom grows to a giant size, it is even rarer for this benign tumour to grow rapidly, ulcerate spontaneously and present like a fungating breast tumour in a way mimicking breast cancer. Case presentation: This is a presentation of a 14 year old premenarchal girl with a massive ulcerating and fungating left breast mass that was initially thought to be a fungating locally advanced breast carcinoma on clinical examination. Further examination of the morphology of the resected surgical specimen and histological examination confirmed it to be giant fibroadenoma of the breast. It was successfully managed by partial mastectomy and breast reconstruction with an excellent result and a high degree of patient satisfaction was achieved. Conclusion: Though a rare clinical entity benign breast tumour can present like a fungating breast cancer and this must be bore in mind especially in young adolescent patients presenting with ulcerating breast tumour.

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“…Fibroadenoma is the most common breast mass in the adolescent 1,2,3 . Giant or juvenile fibroadenoma accounts for 0.5-2 per cent of all cases of fibroadenomas 4 .…”

Section: Introductionmentioning

confidence: 99%

Giant fibroadenoma presenting like fungating breast cancer in a Nigerian teenager

Arowolo¹,

Akinkuolie²,

Adisa³

et al. 2013

Af Hlth Sci

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show abstract

“…Their rapid growth (between two and five months) is associated with skin congestion and ocasionally ulceration. It is thought that increased estrogen receptor sensitivity is responsible for the etiology of GF [1]. …”

Section: Introductionmentioning

confidence: 99%

Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report

et al. 2011

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IntroductionGiant fibroadenoma is an uncommon variant of benign breast lesions. Aberrant methylation of CpG islands in promoter regions is known to be involved in the silencing of genes (for example, tumor-suppressor genes) and appears to be an early event in the etiology of breast carcinogenesis. Only hypermethylation of p16INK4a has been reported in non-giant breast fibroadenoma. In this particular case, there are no previously published data on epigenetic alterations in giant fibroadenomas. Our previous results, based on the analysis of 49 cancer-related CpG islands have confirmed that the aberrant methylation is specific to malignant breast tumors and that it is completely absent in normal breast tissue and breast fibroadenomas.Case presentationA 13-year-old Hispanic girl was referred after she had noted a progressive development of a mass in her left breast. On physical examination, a 10 × 10 cm lump was detected and axillary lymph nodes were not enlarged. After surgical removal the lump was diagnosed as a giant fibroadenoma. Because of the high growth rate of this benign tumor, we decided to analyze the methylation status of 49 CpG islands related to cell growth control. We have identified the methylation of five cancer-related CpG islands in the giant fibroadenoma tissue: ESR1, MGMT, WT-1, BRCA2 and CD44.ConclusionIn this case report we show for the first time the methylation analysis of a giant fibroadenoma. The detection of methylation of these five cancer-related regions indicates substantial epigenomic differences with non-giant fibroadenomas. Epigenetic alterations could explain the higher growth rate of this tumor. Our data contribute to the growing knowledge of aberrant methylation in breast diseases. In this particular case, there exist no previous data regarding the role of methylation in giant fibroadenomas, considered by definition as a benign breast lesion.

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“…Studies have shown that the prevalence of fibroadenomas in the female population range from 7% to 13% [1]. In the female pediatric and adolescent population, fibroadenomas are the most common breast tumors, accounting for 67% to 94% of adolescent breast pathology [3][4][5][6]. Any fibroadenoma that is larger than 5 cm in diameter or weighs more than 500 g can be classified as a giant fibroadenoma, also sometimes referred to as juvenile or cellular fibroadenoma [6,7].…”

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confidence: 99%

Endoscopic specimen pouch technique for removal of giant fibroadenomas of the breast

Cheng

Cass

et al. 2012

Journal of Pediatric Surgery

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Giant fibroadenoma of the breast in adolescents

Cited by 47 publications

References 11 publications

Giant fibroadenoma presenting like fungating breast cancer in a Nigerian teenager

Giant fibroadenoma presenting like fungating breast cancer in a Nigerian teenager

Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report

Endoscopic specimen pouch technique for removal of giant fibroadenomas of the breast

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