Giant fibrous hamartoma of infancy

Abstract

Rationale: Fibrous hamartoma of infancy (FHI) is a rare benign soft-tissue tumor in children with a triphasic organoid histologic appearance. Patient concerns: We here report a case with the largest FHI published so far. A 13-month-old boy with a rapidly growing tumor 45 cm in length and 69.3 cm in circumference of the left lower extremity was identified immediately at birth. Diagnoses: The diagnosis was uncertain before the operation, although biopsy was conducted. The postoperation histological examination showed arranged spindle cells, adipose tissue, and nests of immature small cells embedded in a myxoid background, which is the characteristic triphasic histology of FHI. Interventions: Under general anesthesia, hip and lower extremity amputation was performed. Outcomes: The patient was followed-up for 6 years and no signs of recurrence were found, suggesting a favorable prognosis, although a part of the residual tumor was present after the surgery. Lessons: FHI exhibits pathological and clinical characteristics. However, differential diagnosis of FHI from other soft-tissue tumors before operation remains a challenge. Thus, sometimes, aggressive therapy for the treatment of FHI might be a good choice to get a satisfactory.

Fibrous hamartoma of infancy with bone destruction of the tibia: A case report

“…The location of the disease was the anterolateral part of the middle part of the right tibia. At present, there are few detailed reports on FHI of the tibia[ 1 - 3 , 11 ]. In this patient, the anterolateral cortex of the middle part of the right tibia was destroyed.…”

A rare case report of fibrous hamartoma of infancy: Cyto-histopathological correlation

“…Sometimes, we have to choose aggressive therapeutic approaches for the treatment of FHI when the tumor is very big and deep to get a satisfactory life quality. 10…”