Giant Gastrointestinal Stromal Tumor of the Stomach in An Elderly Patient

Abstract

We report a case of giant gastrointestinal stromal tumor (GIST) of the stomach of 17 cm in diameter detected in an 88-year-old Caucasian female. An en-block resection of the mass requiring gastric and transverse colon resection was carried out. Pathological examination evidenced a smooth multicystic giant gastric GIST measuring 17 x 13 x 9 and weighing 1,630 g. At immunohistochemistry, the specimen was c-kit positive, CD34-positive, SMA-negative S100-negative, desmin-negative, CD31-negative, HMB45-negative, and calponin-negative. It was diagnosed as an uncommitted GIST at high risk for malignancy.

Gastrointestinal stromal tumours can express CD10 and epithelial membrane antigen but not oestrogen receptor or HMB45

“…Both PEComa and melanoma may show immunopositivity for HMB45. 6,14 There have been a few case reports of GIST being HMB45 immunonegative, 15,16 and Guler et al 17 failed recently to demonstrate any HMB45 immunopositivity among 38 cases of GIST. However, the latter study used tissue microarrays which may potentially miss focal positivity.…”

Tumores del estroma gastrointestinal: experiencia en una unidad de oncología

“…De éstos, la tomografía parece tener mayor utilidad, además de tener la ventaja de evidenciar invasión y metástasis. 15 En esta revisión se observó que 45% fue diagnóstico histopatológico posterior a la resección tumoral, mientras que 30% obtuvo diagnóstico histopatológico prequirúrgico por endoscopia y sólo 20% fue por hallazgo tomográfico.…”