Giant GIST of the Small Intestine in a Young Man

Atmatzidis, Stefanos; Chatzimavroudis, Grigoris; Ananiadis, Ananias; Kapoulas, Spyros; Atmatzidis, Konstantinos

doi:10.1007/s11605-013-2268-4

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…GISTs fail to respond to conventional chemotherapy and radiation;10 thus, adjuvant therapy with a tyrosine kinase inhibitor such as imatinib is strongly recommended in high-risk patients to reduce the risk of recurrence 11. Adjuvant therapy should not be applied when the risk of aggressive behavior is low 4…”

Section: Discussionmentioning

confidence: 99%

Management of low rectal gastrointestinal stromal tumor with neoadjuvant therapy and transanal excision: a rare case report and review of the literature

Kosmidis¹,

Sapalidis²,

Tsakalidis³

et al. 2019

IJGM

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Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. However, rectal GISTs represent only 5% of this category. We report a case of a rectal GIST treated with local excision after neoadjuvant therapy. Case presentation A 41-year-old male patient presented with anal bleeding. Colonoscopy revealed a mass located 5 cm from the anal verge. Histological examination showed a GIST with immunohistochemical positivity for CD117 and CD34. Transanal local excision was performed after neoadjuvant therapy. Conclusion Neoadjuvant immunotherapy for GISTs with unfavorable localization may facilitate local excision and avoid complications of more demanding operations.

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Section: Discussionmentioning

confidence: 99%

Management of low rectal gastrointestinal stromal tumor with neoadjuvant therapy and transanal excision: a rare case report and review of the literature

Kosmidis¹,

Sapalidis²,

Tsakalidis³

et al. 2019

IJGM

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“…Stromal tumors localized in the small intestine are rare, more growing outside and not into the lumen of the intestine. In the literature there are case descriptions of in growing GIST tumors causing intestinal obstruction or bleeding [8,9]. Tumors can occur in any part of the small intestine, and externally can grow large, being asymptomatic.…”

Section: Discussionmentioning

confidence: 99%

Parietal Strangulation of Small Intestine in Femoral Hernia Site with Symptoms of Intestinal Obstruction in Patient with Incidentally Found Small Intestine Tumor: A Case Report

Włodzimierz¹

2015

Surgery Curr Res

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Richter's hernia (partial enterocele) is the strangulation/entrapment of only part of the circumference of the intestinal wall. It is relatively rare, and presents without mechanical obstruction -giving vague, non-specific symptoms and signs, and a threat of intestinal necrosis, gangrene, followed by perforation. A report of a case of entrapment of the jejunum in the femoral ring, which did not cause the gangrene, but symptoms of mechanical obstruction, is presented. Further inspection of the small bowel in this case revealed an extra-luminal tumour, which appeared to be a GIST. The entrapped part of the jejunum has been released and the tumour has been resected.

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“…Segmental or wedge resection aimed at histologically negative margins is ideal. Wide excision with multivisceral and radical en bloc excisions should be avoided [1] as GISTs do not typically spread intramurally though a clear margin of 1 -3 cm has been recommended by some authors [9] whereas others suggest that microscopically free millimeter margin is sufficient in gastric GISTs [13]. Incomplete tumor excision is, however, associated with a decreased 5-year survival of 8% -9% (compared with 42% in complete resection) [5].…”

Section: General Principlesmentioning

confidence: 99%

“…Three characteristics on histopathology have been reported to predict GIST behavior: size, mitotic rate, and tumor location [9]. Mitotic index is the main predictor of recurrence, with tumors at least 5 mitoses/50HPF being 15-fold more likely to recur than those with <5 mitoses/50HPF.…”

Section: Histopathologymentioning

confidence: 99%

Gastrointestinal Stromal Tumors in the 21st Century

Kanthan¹,

Senger²,

Ahmed³

et al. 2014

JCT

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Gastrointestinal stromal tumours (GISTs) are rare mesenchymal lesions accounting for only 0.2% of all gastrointestinal neoplasms. These tumors arise from the interstitial cells of Cajal, with mutations described in proto-oncogenes such as KIT, PDGFRA, DOG-1, and SDH. The majority of these lesions are asymptomatic, thus the true incidence remains unknown. While patients typically undergo initial endoscopy, CT scan and/or MRI, findings are often nonspecific and require a biopsy to identify the tumor. As such, immunohistochemical evaluation is the gold-standard for the accurate diagnosis of GIST. Though surgical excision remains the gold-standard for curative management, the discovery of imatinib, a tyrosine kinase inhibitor (TKI), has revolutionized the treatment of GIST in the 21 st century as a "prototype" of molecular targeted therapy for solid tumors. Risk assessment for recurrence divides these tumors into low and high-risk categories. In the latter, a role for adjuvant therapy with TKI confers a significantly better prognosis than previously observed. However, secondary mutations conferring drug resistance remain an ongoing challenge for management, as few alternative treatment options are available for patients intolerant/refractory to TKI therapy. In this review, we summarize the epidemiology, molecular pathogenesis, clinical presentation, diagnosis, pathology features, management options, and prognostic features of GISTs.

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Giant GIST of the Small Intestine in a Young Man

Cited by 5 publications

References 10 publications

<p>Management of low rectal gastrointestinal stromal tumor with neoadjuvant therapy and transanal excision: a rare case report and review of the literature</p>

<p>Management of low rectal gastrointestinal stromal tumor with neoadjuvant therapy and transanal excision: a rare case report and review of the literature</p>

Parietal Strangulation of Small Intestine in Femoral Hernia Site with Symptoms of Intestinal Obstruction in Patient with Incidentally Found Small Intestine Tumor: A Case Report

Gastrointestinal Stromal Tumors in the 21<sup>st</sup> Century

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Giant GIST of the Small Intestine in a Young Man

Cited by 5 publications

References 10 publications

<p>Management of low rectal gastrointestinal stromal tumor with neoadjuvant therapy and transanal excision: a rare case report and review of the literature</p>

<p>Management of low rectal gastrointestinal stromal tumor with neoadjuvant therapy and transanal excision: a rare case report and review of the literature</p>

Parietal Strangulation of Small Intestine in Femoral Hernia Site with Symptoms of Intestinal Obstruction in Patient with Incidentally Found Small Intestine Tumor: A Case Report

Gastrointestinal Stromal Tumors in the 21&lt;sup&gt;st&lt;/sup&gt; Century

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Gastrointestinal Stromal Tumors in the 21<sup>st</sup> Century