Giant granular cell tumor of the vulva

“…However, unlike Bartholin's cyst that has a specific vulva anatomic position, granular cell tumor can occur anywhere in the vulva. Aside from the histological features described above, the granularity of the cytoplasm is typical in these tumors and is caused by the accumulation of phagolysosomes [6]. Secondary to the neurogenic origin, immunohistochemical staining is positive for S100, neuron-specific enolase, peripheral nerve myelin proteins and vimentin.…”

Section: Discussionmentioning

confidence: 94%

“…However, because of the potential for recurrence and indeed malignancy, the current recommendation is wide local excision with clear margins [6]. Reports of the rate of recurrence of granular cell tumors vary anywhere from 2% to 10% [5,6].…”

Section: Discussionmentioning

confidence: 99%

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Incidental Diagnosis of Granular Cell Tumor of Vulva: Importance of Discussing Vulvar Health at the Annual Well-Woman Examination

et al. 2015

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Granular cell tumors are rare tumors of neurogenic or Schwann cell origin and are known to involve the vulva. The objective of this case is to highlight the importance of careful vulvar examination during the annual well-woman examination by presenting a case of an incidental finding of granular cell tumor of the vulva. A 55-year-old African American female was noted to have an incidental finding of a 2 × 2 cm slow growing right vulvar lump at her yearly gynecologic exam. The lesion was excised and the histopathology was consistent with a benign granular cell tumor of the vulva. Immunostaining was positive for S100 and neuron-specific enolase. Asymptomatic vulvar masses can be the only presenting feature of a neoplastic process. Women may not seek medical attention due to embarrassment or lack of recognizing the importance of symptoms. This case report highlights such a scenario as a reminder to carefully examine the vulva during annual well-woman examination. A low threshold for biopsy can assist in diagnosing pre-invasive and invasive vulvar lesions.

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“…Benign vulvar lesions usually appear on the labia major, but also in other sites such as clitoral (5 cases), perianal (2 cases), perineal (2 cases), introitus (1 case) and episiotomy scar (1 case). The mean size of the benign tumors is 2.6 cm (range from microscopic [11] to 7 × 5 × 5 cm [12]) and for the malignant variant the mean is 6.34 cm (range 1.5–12 cm).…”

Section: Discussionmentioning

confidence: 99%

Benign Granular Cell Tumor of the Vulva: First Report of Multiple Cases in a Family

Kardhashi

Deliso

Renna

et al. 2012

Gynecol Obstet Invest

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Granular cell tumors (GCTs) are uncommon soft tissue tumors of neural derivation, as supported by immunohistochemical and ultrastructural evidence. Vulvar involvement has been reported in 7–16%. This paper presents the cases of a 60-year-old woman and her 32-year-old niece with a strong family history of cancer, both presenting with an enlarging mass on their left labia majora. The lesions were treated by simple surgical excision. Histopathological examination revealed a benign vulvar GCT in both lesions. This is the first reported case of GCT of the vulva in the same family. The possible familial component of GCT needs further investigation. A systematic review of the literature on vulvar GCTs is carried out, the most complete one to date. This review unexpectedly reveals that there have been more than 130 cases of GCT of the vulva reported to date, only 7 of which were malignant. Since 5–25% of patients have multiple lesions, before planning treatment, clinicians should exclude multicentric lesions. After surgical treatment, if there is any evidence of tumor in the surgical margin, wider local excision should be performed. Regular follow-up is important for diagnosing a possible recurrence or a new lesion.

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Giant granular cell tumor of the vulva

Cited by 8 publications

References 3 publications

Granular Cell Tumor of the Vulva

Granular Cell Tumor of the Vulva

Incidental Diagnosis of Granular Cell Tumor of Vulva: Importance of Discussing Vulvar Health at the Annual Well-Woman Examination

Benign Granular Cell Tumor of the Vulva: First Report of Multiple Cases in a Family

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