Giant hepatocellular adenoma in a previously obese thirteen-year-old boy

Rosencrantz, Richard; Wu, Youmin; Sonke, Pierre-Yves; Yusuf, Yasmin

doi:10.1016/s1665-2681(19)31180-9

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…While these patients can be bridged safely, the outcomes are not well reported. In case reports, complications for ruptured pediatric HCAs include bile leaks, abscess formation, and respiratory complications [48]. In contrast, non-ruptured pediatric HCAs have been reported to do well post-operatively [35,36].…”

Section: Management Complications and Prognosismentioning

confidence: 99%

Pediatric Hepatocellular Adenomas: What Is Known and What Is New?

Espinoza,

Vasudevan,

Masand

et al. 2023

Cancers

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Current understanding and classification of pediatric hepatocellular adenomas (HCA) are largely based on adult data. HCAs are rare in children and, unlike in adults, are often seen in the context of syndromes or abnormal background liver. Attempts to apply the adult classification to pediatric tumors have led to several “unclassifiable” lesions. Although typically considered benign, few can show atypical features and those with beta-catenin mutations have a risk for malignant transformation. Small lesions can be monitored while larger (>5.0 cm) lesions are excised due to symptoms or risk of bleeding/rupture, etc. Management depends on gender, age, underlying liver disease, multifocality, size of lesion, histologic subtype and presence of mutation, if any. In this review, we summarize the data on pediatric HCAs and highlight our experience with their diagnosis and management.

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Section: Management Complications and Prognosismentioning

confidence: 99%

Pediatric Hepatocellular Adenomas: What Is Known and What Is New?

Espinoza,

Vasudevan,

Masand

et al. 2023

Cancers

View full text Add to dashboard Cite

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Giant Hepatic Adenoma in a 12-Year-Old Girl

Singh

Patkar

Polnaya

et al. 2017

J Gastrointest Canc

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Hepatocellular Adenoma: Report of 2 Cases That Highlight the Relevance of Phenotype-Genotype Correlation in the Pediatric Population

et al. 2023

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Background: Hepatocellular adenoma (HCA) in the pediatric population is very rare and there are only limited studies, especially with molecular characterization of the tumors. Main HCA subtypes recognized in the current WHO classification include HNF1A-inactivated HCA (H-HCA), inflammatory HCA (IHCA), β-catenin-activated HCA (b-HCA), and β-catenin-activated IHCA (b-IHCA) and sonic hedgehog HCA (shHCA) is reported as an emerging subtype. Methods: Clinical history, pathological information, and molecular studies for a series of 2 cases of pediatric HCA were reviewed. Results: Case 1 was a b-HCA characterized by somatic CTNNB1 S45 mutation in a 11-year-old male with Abernethy malformation. Case 2 was a H-HCA characterized by germline HNF1A variant (c.526+1G>A) in a 15-year-old male associated with maturity-onset diabetes of the young type 3 (MODY3). Conclusion: Our findings highlight the rarity of these 2 cases associated with adenomatosis, and the contribution of molecular/genetic analysis for proper sub-typing, prognosis and family surveillance.

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Giant hepatocellular adenoma in a previously obese thirteen-year-old boy

Cited by 4 publications

References 21 publications

Pediatric Hepatocellular Adenomas: What Is Known and What Is New?

Pediatric Hepatocellular Adenomas: What Is Known and What Is New?

Giant Hepatic Adenoma in a 12-Year-Old Girl

Hepatocellular Adenoma: Report of 2 Cases That Highlight the Relevance of Phenotype-Genotype Correlation in the Pediatric Population

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