Giant hidradenocarcinoma: A report of malignant transformation from nodular hidradenoma

Abstract

A giant hidradenocarcinoma presented by a 75-year-old female is reported. The patient had a malignant transformation within a nodular hidradenoma involving the right postauricular area, which was treated by mass removal and a right radical neck dissection with a free-flap covering. Malignant hidradenocarcinoma is the least common adnexal tumor of uncertain origin. They are usually malignant from their inception, but some develop from a benign counterpart. To the authors' knowledge, only three cases have been reported previously. Two histologically distinct components were seen in this tumor: (i) typical nodular hidradenoma, which constituted a small part of the tumor; and (ii) carcinoma with areas of transition. The secretory cells of hidradenocarcinoma showed decapitation secretion on light and electron microscopic observations, which is evidence of apocrine differentiation. Histologically, this case was concluded as a hidradenocarcinoma arising from a long-standing nodular hidradenoma. A literature review is presented and the histological, immunohistochemical and ultrastructural features are described.

Giant Poroid Submental Hidradenocarcinoma: Radiological Evaluation – Case Report

“…[1] In our case also the history was very long and likelihood of earlier benign tumor was very high.The size can be very big and this also indicates the aggressiveness of the tumor. [2] These can present with some complication like acute cardiac failure. [3] These tumors require differentiation from metastatic and other malignancies like squamous cell and basal cell carcinomas.…”

First Case Report of Locally Advanced Malignant Nodular Hidradenoma of the Scrotum

“…Two patients were disease-freeat27and35months,respectively,and1patient died of metastatic disease. Similarly, Lim et al [9] reported a case of giant hidradenocarcinoma with metastases soon after surgery and adjuvant radiotherapy. Local radiotherapy maybeusefulinthepresenceofdermallymphaticinvasion, nerve-s heathinvolvement,deepstructureinfiltration,positive resection margins, highly anaplastic morphology, and extracapsularlymphnodeextension [8].Furthertrialsareneeded todefinetheroleofradiotherapyandchemotherapy.Estrogenreceptoranalysishasbeenrecommendedbysome authors [5,10,11].…”

Giant Hidradenoma of the Thigh a 14-Year Old Boy

“…They generally enlarge slowly, can be solid or cystic clinically. When they reach to large sizes they are referred as giant hidradenomas which may present with tenderness and change in skin color (5)(6)(7)(8). Hidradenomas are usually slow growing tumors but as in our case they may show abrupt progression.…”

“…The differential diagnosis must include cyctic hygroma, soft tissue tumors like fibrosarcoma, synovial cell sarcoma, osteochondroma and neuroblastoma metastasis in childhood (3,9). Histapathology and immunohistochemical staining are helpful in differentiation and final diagnosis (3,8,9). Hidradenomas are characterized by cuboidal or columnar cells lining tubular lumina and they also contain cystic spaces.…”