Giant leiomyosarcoma of the rectum with lymph node metastasis: A case report and review of the literature

Anzai, Hiroyuki; Nozawa, Hiroaki; Tanaka, Junichiro; Yasuda, Koji; Otani, Kensuke; Nishikawa, Takeshi; Tanaka, Toshiaki; Kiyomatsu, Tomomichi; Hata, Keisuke; Kawai, Kazushige; Ushiku, Tetsuo; Ishihara, Soichiro; Takano, Toshimi; Fukayama, Masashi; Watanabe, Toshiaki

doi:10.1016/j.ijscr.2017.03.008

Cited by 5 publications

(17 citation statements)

References 23 publications

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“…The immunohistochemical analysis observed in this study is in agreement with other studies on leiomyosarcoma (Kumar et al, 2016;Sazaki et al, 2016;Anzai et al, 2017), allowing the diagnostic conclusion.…”

Section: Discussionsupporting

confidence: 93%

“…Most reports about this neoplasm focus on its occurrence in humans (Daudia et al, 2001;Piovanello et al, 2007;Patrono et al, 2014). Giant leiomyosarcoma has been reported in humans in different tissues, such as kidney (Öziş, et al, 2014), uterus (Senol et al, 2016), subcutaneous tissues (Kumar et al, 2016), and rectum (Anzai, 2017). However, no reports of giant leiomyosarcoma in canine species have been reported.…”

Section: Discussionmentioning

confidence: 99%

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Occurrence of splenic leiomyosarcoma in dog: anatomopathological findings

et al. 2017

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Leiomyosarcoma is a malignant neoplasm with origin in smooth muscles. It can originate in the vessel wall and interstitium of the spleen smooth muscle, which is considered rare. The objective of this study was to describe clinical and anatomopathological findings of a splenic leiomyosarcoma in an eight-year-old bitch of the Fila breed. This splenic leiomyosarcoma weighed 9.2 kg, and had 30×27×14 cm in dimension, rounded shape, irregular outline, reddish color alternating with pale areas, friable and hemorrhagic tissues, and necrotic center. After conventional histopathological examination, the suspected diagnosis (leiomyosarcoma) was confirmed by histochemical analysis using Masson's trichrome staining (which showed the reactivity of the muscle tissue) and by immunohistochemical analysis, showed positivity for smooth muscle actin, vimentin, and desmin. This study emphasizes the importance of associating histopathological evaluation with histochemical and immunohistochemical techniques for a diagnosis of this neoplasm. The occurrence of leiomyosarcoma reported here denotes the importance of considering it for a differential diagnosis in cases of splenic tumors.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Occurrence of splenic leiomyosarcoma in dog: anatomopathological findings

et al. 2017

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“…Anzai et al and Yahagi et al reviewed reports of 14 cases of leiomyosarcoma of the rectum and 27 cases of leiomyosarcoma of the colon published after 1998, when the diagnosis by immunostaining method was established [10,11]. Although some cases of colorectal leiomyosarcoma have since been reported, only 1 case exhibited lymph node metastasis [6,10]. The clinicopathological characteristics of this previous case and our own are summarized in Table 1 [6,10].…”

Section: Discussionmentioning

confidence: 67%

“…Although some cases of colorectal leiomyosarcoma have since been reported, only 1 case exhibited lymph node metastasis [6,10]. The clinicopathological characteristics of this previous case and our own are summarized in Table 1 [6,10]. Among these 2 cases, both patients were females in the age range of 72 to 76 years, and the primary organs were the rectosigmoid and left side of the transverse colon.…”

Section: Discussionmentioning

confidence: 80%

“…In soft tissue tumors, except for epithelioid sarcoma and clear cell sarcoma, lymph node metastasis is rare [8]. Anzai et al and Yahagi et al reviewed reports of 14 cases of leiomyosarcoma of the rectum and 27 cases of leiomyosarcoma of the colon published after 1998, when the diagnosis by immunostaining method was established [10,11]. Although some cases of colorectal leiomyosarcoma have since been reported, only 1 case exhibited lymph node metastasis [6,10].…”

Section: Discussionmentioning

confidence: 99%

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Leiomyosarcoma of the transverse colon with lymph node metastasis and malignant transformation: a case report

et al. 2020

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Background The concept of GIST was established in 1998, clearly differentiating between gastrointestinal leiomyosarcoma and GISTs among gastrointestinal mesenchymal tumors. Lymph node metastasis is extremely rare in true gastrointestinal leiomyosarcoma, and there are no reports of malignant transformation from leiomyoma. Case presentation The patient was an old woman who had undergone endoscopic mucosal resection for an Is polyp on the left side of the transverse colon at the age of 73. She was diagnosed with leiomyoma with positive surgical margins. Subsequently, she presented to our institution with a sensation of pressure in the upper abdominal region as a chief complaint at the age of 76 years. Abdominal computed tomography and colorectal endoscopy showed a tumor lesion with invagination of the intestines in the transverse colon, the same site as that of the previously resected leiomyoma. A biopsy suggested a smooth muscle tumor, and we performed partial left transverse colectomy and lymph node dissection under a diagnosis of recurrence and enlargement of the previously incompletely resected leiomyoma. Histopathological examination revealed spindle-shaped tumor cells, and the mitotic activity was 30–40/10 high-power field. Tumor cells were immunohistologically positive for α-smooth muscle actin and h-caldesmon; partially positive for desmin; negative for c-kit, CD34, DOG-1, and the S-100 protein; and showed a Ki-67 labeling index of 70–80%. She was diagnosed with leiomyosarcoma malignantly transformed from leiomyoma. Metastasis was found in 1 of the 14 resected lymph nodes. The patient did not undergo adjuvant chemotherapy, but has survived with no recurrence at 2 years after the surgery. Conclusions We have reported a case of leiomyosarcoma of the transverse colon with lymph node metastasis that was malignantly transformed from a leiomyoma.

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Leiomyosarcoma of the rectum: A systematic review of recent literature

Annicchiarico,

Montali,

Baldinu

et al. 2023

Journal of Surgical Oncology

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Leiomyosarcomas (LMSs) are rare tumors originating from the muscular layer. We performed a literature review of cases of confirmed rectal leiomyosarcomas (rLMSs) to clarify the history of such an infrequent tumor arising at such an uncommon location. In this research local recurrence was related to poorly differentiated rLMS and no other association between recurrence and any criteria was found. Concerning overall survival (OS), rLMS patients developing recurrence presented shorter longevity compared with the group without.

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Giant leiomyosarcoma of the rectum with lymph node metastasis: A case report and review of the literature

Cited by 5 publications

References 23 publications

Occurrence of splenic leiomyosarcoma in dog: anatomopathological findings

Occurrence of splenic leiomyosarcoma in dog: anatomopathological findings

Leiomyosarcoma of the transverse colon with lymph node metastasis and malignant transformation: a case report

Leiomyosarcoma of the rectum: A systematic review of recent literature

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