Giant Melanoma and Depression

Boz, J. del; Garcia, J. M.; Martínez, Silvestre; Gómez, Marina

doi:10.2165/11311050-000000000-00000

Cited by 15 publications

(10 citation statements)

References 7 publications

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“…Significant psychiatric and psychosocial comorbidity is present in at least 30% of dermatological patients 9. In our case, it is possible that dementia delayed the diagnosis, as the patient did not observe anything unusual.…”

Section: Discussionmentioning

confidence: 60%

Giant verrucous carcinoma of the lower extremity in women with dementia

Jungmann

Vogt²,

Müller³

2012

BMJ Case Reports

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SummaryWe present the case of an 81-year-old woman with dementia and a giant exophytic ulcerated tumour, which covered most of the lower leg and the dorsum of the foot and emitted a foul smell. The patient had chronic venous insufficiency for 30 years, and previously (appr. 20 years ago) had a squamous cell carcinoma in the same location (right lower leg) that could be treated surgically. The dermatopathological examination of a large excisional biopsy revealed a highly differentiated verrucous carcinoma (formerly referred to as papillomatosis cutis carcinoides). Pathologically modified lymph nodes (suspicious of lymphatic metastases) were observed. Possible treatment options (surgery, intralesional and systemic treatment) were discussed. Finally, due to extension, location of the tumour and the age and co-morbidities of the patient, a decision was made to perform radiation therapy. BACKGROUND

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Section: Discussionmentioning

confidence: 60%

Giant verrucous carcinoma of the lower extremity in women with dementia

Jungmann

Vogt²,

Müller³

2012

BMJ Case Reports

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“…Our case highlights that, often, patients who present late with such extreme tumours can have underlying phobias or anxieties. Both Tseng et al 7 and del Boz et al 6 have noted a similar trend including mental health conditions and self-neglect. As a patient group, they may not be suitable for adjuvant therapy due to phobia or compliance issues.…”

Section: Discussionmentioning

confidence: 63%

Patient with giant upper limb melanoma presenting to a UK plastic surgery unit: differentials and experience of management

Honeyman

Wilson

2016

BMJ Case Reports

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SUMMARYA 57-year-old woman was referred to our regional sarcoma unit following a 2-year history of a progressively enlarging mass on her right forearm. At 14×7×12 cm, this mass turned out to be one of the largest upper limb cutaneous malignant melanomas ever described, and, to the best of our knowledge, the first documented in the UK. Remarkably, despite having a T4 malignant tumour with a Breslow thickness of 70 mm, this patient is still alive over 4 years later with no locoregional or distant metastatic spread. We present our experience in the management of this giant malignant melanoma of the upper limb and consider important differentials. BACKGROUND

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“…In the case of CM, current data suggest that, whereas some cases appear and metastasize very quickly (del Boz et al, 2009), others grow extremely slowly, with metastasis appear-ing many years later (Nozaki et al, 1999). In fact, the time of appearance of the metastasis can be represented in terms of the growth rate (GR) of the melanoma, with the time of appearance of metastasis being inversely proportional to the GR of the melanoma (Tejera-Vaquerizo et al, 2011), with the GR being a measurement defined by the tumor thickness per unit of time.…”

Section: Introductionmentioning

confidence: 82%

Chronology of Metastasis in Cutaneous Melanoma: Growth Rate Model

Tejera‐Vaquerizo

Nagore

Meléndez

et al. 2012

Journal of Investigative Dermatology

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In humans, it is not possible to obtain experimental evidence of when a cancer begins to metastasize. The purpose of this study was to estimate the time of onset of metastatic dissemination in cutaneous melanoma using a model based on its growth rate (GR). The critical time of onset of metastatic dissemination below which no cases of fatal melanomas were seen may be described with a potential function in which this time is inversely proportional to the GR. The critical time of development beyond which a melanoma may metastasize presents great variation. This time was just 1 month for those melanomas with a fast GR, whereas it was over 5 years for those with a very slow GR. Quantitatively, the fastest-growing melanomas began metastasizing with a greater thickness than the slowest-growing melanomas. A correlation exists between the critical time of onset of metastatic potential and the GR of the melanoma. These results may well have relevance to the understanding of mechanisms of tumor dissemination and for the design of future studies on melanomas, irrespective of whether they are basic studies on biomolecular mechamisms or clinical studies.

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Giant Melanoma and Depression

Cited by 15 publications

References 7 publications

Giant verrucous carcinoma of the lower extremity in women with dementia

Giant verrucous carcinoma of the lower extremity in women with dementia

Patient with giant upper limb melanoma presenting to a UK plastic surgery unit: differentials and experience of management

Chronology of Metastasis in Cutaneous Melanoma: Growth Rate Model

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