2011
DOI: 10.1155/2011/849767
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Giant Merkel Cell Carcinoma Masquerading as a Benign Cyst on the Buttock of an African American Man

Abstract: We report a case of a 60-year-old African American man who presented with a 4-year history of a previously asymptomatic, recently enlarging nodule on his left buttock, which was initially presumed to be an epidermoid cyst. Physical examination revealed a large, fixed, subcutaneous tumor, and a biopsy revealed merkel cell carcinoma. Immunohistochemical staining was positive for pankeratin, CAM 5.2, synaptophysin, and CD56 and negative for CK7, CK20, TTF-1, chromogranin, CD3, CD20, CD57, MART1, and HMB 45. The p… Show more

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Cited by 7 publications
(6 citation statements)
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“…Table 1 shows the characteristics of these atypical cases. Except for our case and that reported by Perman and colleagues, 15 the other cases affected elderly patients (median age 81 years). Most were white and female.…”
Section: Discussioncontrasting
confidence: 41%
“…Table 1 shows the characteristics of these atypical cases. Except for our case and that reported by Perman and colleagues, 15 the other cases affected elderly patients (median age 81 years). Most were white and female.…”
Section: Discussioncontrasting
confidence: 41%
“…Diagnosis is established by biopsy, and to differentiate MCC from other tumors, immunohistochemistry is performed (5) . This study highlights positivity for cytokeratin 20 (whose expression is detected in 89%-100% of MCC) (10) and negativity for TTF-1 (which is specific for small cell lung carcinoma) (6) as important tools for the differential diagnosis of MCC.…”
Section: Discussionmentioning
confidence: 80%
“…It is worth mentioning that one of our male patients developed MCC in a non-sunexposed area of the gluteal region. Only a few other cases of MCC involving this anatomical site (all male) were reported previously [17][18][19].…”
Section: Discussionmentioning
confidence: 95%