Giant milkweed plant-based copper oxide nanoparticles for wound dressing application: physicochemical, bactericidal and cytocompatibility profiles

Govindasamy, G Ambarasan; Mydin, Rabiatul Basria S. M. N.; Harun, Nor Hazliana; Effendy, Wan Nuramiera Faznie Wan Eddis; Sreekantan, Srimala

doi:10.1007/s11696-022-02513-5

Cited by 16 publications

(2 citation statements)

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“…The wound healing potential of plant-derived copper oxide(II) nanoparticles was the subject of Govindasamy and co-authors [ 63 ]. The authors evaluated the antibacterial properties of CuO nanoparticles from the giant milkweed plant, commonly known as Calotropis gigantea .…”

Section: Antibacterial Properties Of Copper and Copper-based Nanomate...mentioning

confidence: 99%

“…The plant-derived CuO NPs effectively reduced the growth of E.coli , S. aureus , K. pneumoniae , and methicillin-resistant Staphylococcus aureus (MRSA) bacterial strains. Moreover, the decoration of copper oxide(II) nanoparticles with Calotropis gigantea plant extract provided excellent cytocompatibility in vitro [ 63 ]. Sen and Sarkar examined the wound healing potential of glutathione and citrate-coated copper/copper oxide(I) nanoparticles in vivo against two multidrug-resistant bacteria, i.e., Klebsiella and Enterobacter (albino Wistar rat model) [ 64 ].…”

Section: Antibacterial Properties Of Copper and Copper-based Nanomate...mentioning

confidence: 99%

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Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges

Woźniak-Budych,

Staszak,

Staszak

2023

Molecules

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Nanotechnology has ushered in a new era of medical innovation, offering unique solutions to longstanding healthcare challenges. Among nanomaterials, copper and copper oxide nanoparticles stand out as promising candidates for a multitude of medical applications. This article aims to provide contemporary insights into the perspectives and challenges regarding the use of copper and copper oxide nanoparticles in medicine. It summarises the biomedical potential of copper-based nanoformulations, including the progress of early-stage research, to evaluate and mitigate the potential toxicity of copper nanomaterials. The discussion covers the challenges and prospects of copper-based nanomaterials in the context of their successful clinical translation. The article also addresses safety concerns, emphasizing the need for toxicity assessments of nanomedicines. However, attention is needed to solve the current challenges such as biocompatibility and controlled release. Ongoing research and collaborative efforts to overcome these obstacles are discussed. This analysis aims to provide guidance for the safe and effective integration of copper nanoparticles into clinical practice, thereby advancing their medical applications. This analysis of recent literature has highlighted the multifaceted challenges and prospects associated with copper-based nanomaterials in the context of their translation from the laboratory to the clinic. In particular, biocompatibility remains a formidable hurdle, requiring innovative solutions to ensure the seamless integration into the human body. Additionally, achieving the controlled release of therapeutic agents from copper nanoparticles poses a complex challenge that requires meticulous engineering and precise design.

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Section: Antibacterial Properties Of Copper and Copper-based Nanomate...mentioning

confidence: 99%

Section: Antibacterial Properties Of Copper and Copper-based Nanomate...mentioning

confidence: 99%