Giant multimodal heart motoneurons of Achatina fulica: a new cardioregulatory input in pulmonates

Zhuravlev, V. L.; Bugaj, V.; Kodirov, Sodikdjon A.; Safonova, T. A.; Staruschenko, Alexander

doi:10.1016/s1095-6433(01)00384-1

Cited by 18 publications

(10 citation statements)

References 30 publications

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“…This response strongly resembled the pentylenetetrazol -induced seizure changes in cerebral cortical neurons of mammals (Sugaya et al, 1964). The snail and its central neurons have been widely used as animal models to test the physiological functions or the modes of action of active components (Kiss et al, 2002(Kiss et al, , 2003Koss et al, 2003;Straub and Benjamin, 2001;Zhuravlev et al, 2001;Tsai, 1996, 2000). In the present study, effects of procaine on the central neuron of the snail were tested on the RP1 neuron of an African snail.…”

Section: Introductionmentioning

confidence: 80%

Effects of procaine on a central neuron of the snail, Achatina fulica Ferussac

Lin

Tsai

2005

Life Sciences

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Section: Introductionmentioning

confidence: 80%

Effects of procaine on a central neuron of the snail, Achatina fulica Ferussac

Lin

Tsai

2005

Life Sciences

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“…The left posterior pallial nerve ( lppn ) connects d-VLN/d-RPLN (dorsal visceral large neuron and dorsal right parietal large neuron) and the heart of Achatina . Stimulation of these neurons evokes junction potentials (JPs) in the myocardium (Zhuravlev et al, 2001). The d-VLN and d-RPLN (known also as r-PLN) are symmetrical giant neurons located in visceral and right parietal ganglia, respectively (Fig.…”

Section: Molluscan Heartsmentioning

confidence: 99%

“…During prolonged burst, the rate and magnitude of heartbeat were dramatically increased; these effects lasted longer than the duration of burst and the inotropic effect reversed gradually, while the chronotropic one abruptly. In Achatina, the APs of d-VLN evoke inhibitory–excitatory junction potentials (I–EJPs) in the myocardium (Zhuravlev et al, 2001). Similar neuron in ventral surface of visceral ganglion is designated as v-VLN (Liu and Takeuchi, 1993).…”

Section: Excitation Of Heartmentioning

confidence: 99%

“…Despite the fact that a significant body of work concerned the neuronal regulation of heart (Furukawa and Kobayashi, 1987b; Zhuravlev et al, 2001), there are scant studies on ion channels in the cardiomyocytes of pulmonate snails in particular, and Mollusca in general. Extensive studies on ionic currents including single channel recordings are available exclusively in the cardiac cells of pond snail Lymnaea (Brezden et al, 1986; Brezden and Gardner, 1992; Brezden et al, 1999; Yeoman et al, 1999).…”

Section: Cardiac Ion Channelsmentioning

confidence: 99%

“…The relative size of neurons to each other is considered. Modified from the original studies (Jaeger et al, 1971; Kerkut et al, 1975; Chase and Goodman, 1977; Isao, 1980; Ku and Takeuchi, 1985; Furukawa and Kobayashi, 1987a; Croll, 1988; Buckett et al, 1990a; Zhuravlev et al, 1997; Zhuravlev et al, 2001; Zhuravlev et al, 2002). …”

Section: Figmentioning

confidence: 99%

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The neuronal control of cardiac functions in Molluscs

Kodirov

2011

Comparative Biochemistry and Physiology Part A: Molecular &

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In this manuscript, I review the current and relevant classical studies on properties of the Mollusca heart and their central nervous system including ganglia, neurons, and nerves involved in cardiomodulation. Similar to mammalian brain hemispheres, these invertebrates possess symmetrical pairs of ganglia albeit visceral (only one) ganglion and the parietal ganglia (the right ganglion is bigger than the left one). Furthermore, there are two major regulatory drives into the compartments (pericard, auricle, and ventricle) and cardiomyocytes of the heart. These are the excitatory and inhibitory signals that originate from a few designated neurons and their putative neurotransmitters. Many of these neurons are well-identified, their specific locations within the corresponding ganglion are mapped, and some are termed as either heart excitatory (HE) or inhibitory (HI) cells. The remaining neurons are classified as cardio-regulatory, and their direct and indirect actions on the heart’s function have been documented. The cardiovascular anatomy of frequently used experimental animals, Achatina, Aplysia, Helix, and Lymnaea is relatively simple. However, as in humans, it possesses all major components including even trabeculae and atrio-ventricular valves. Since the myocardial cells are enzymatically dispersible, multiple voltage dependent cationic currents in isolated cardiomyocytes are described. The latter include at least the A-type K+, delayed rectifier K+, TTX-sensitive Na+, and L-type Ca2+ channels.

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Probability that there is a mammalian counterpart of cardiac clock in insects

Kodirov

2022

Arch Insect Biochem Physiol

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Whether or not the hyperpolarization‐activated cyclic nucleotide‐gated nonselective cation channel (HCN or funny current If) is involved in pacemaking − recurrent heartbeat, it is attributed to electrical activities in all excitable cells, including those of invertebrates. In latter group of animals prevailingly the electrical signals and function of heart in terms of chrono‐ and inotropy are elucidated. Although in simpler models including insects experimental outcomes are reproducible and robust, involvement of “cardiac clock” mechanism in pacemaking is not conclusive. In this assay, the mechanisms of heartbeat are synthesized by focused comparisons between insect and mammalian hearts.

show abstract

Giant multimodal heart motoneurons of Achatina fulica: a new cardioregulatory input in pulmonates

Cited by 18 publications

References 30 publications

Effects of procaine on a central neuron of the snail, Achatina fulica Ferussac

Effects of procaine on a central neuron of the snail, Achatina fulica Ferussac

The neuronal control of cardiac functions in Molluscs

Probability that there is a mammalian counterpart of cardiac clock in insects

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