Giant myxoinflammatory fibroblastic sarcoma with bone invasion: a very rare clinical entity and literature review

Abstract

Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare low-grade, malignant soft tissue tumor that is usually observed in the extremities of adult patients. Magnetic resonance imaging findings for this tumor type have rarely been reported. We report a case involving the distal left femur of a middle-aged man and tumoral invasion of the bone, which, to our knowledge, has been previously described only once. He was treated with distal femoral tumor resection and reconstruction with a modular prosthesis. Histopathologic diagnosis confirmed MIFS. We reviewed literature of the diagnostic imaging and bone invasion findings associated with this tumor type.

Large cervicothoracic myxoinflammatory fibroblastic sarcoma with brachial plexus invasion: A case report and literature review

“…To the best of our knowledge, the present case of a cervicothoracic myxoinflammatory fibroblastic sarcoma with brachial plexus invasion is the first to be reported in the literature. The largest myxoinflammatory fibroblastic sarcoma reported previously was 16 cm in size ( 8 ), while the supraclavicular and infraclavicular masses identified in this case were 10×5×3 cm and 25×18×8 cm, respectively.…”

“…A painless slow-growing mass or swelling is the most common initial complaint in patients with myxoinflammatory fibroblastic sarcoma. A number of individuals also present with pain, tenderness or dysfunction of the affected area ( 8 ). The symptoms observed in the patient in the present case are consistent with those reported in the literature ( 2 ).…”

Myxoinflammatory Fibroblastic Sarcoma of the Scalp

“…Although the numbers studied are relatively few, α1-antitrypsin, EGFR, and CD163 are reported to be consistently positive. [2][3][4]6,7,[11][12][13][14][15][16][17][18][19][20][21][22][23][24] Genetically, MIFS has been shown to be associated with t(1;10)(p22:q24), with rearrangements of the TGFBR3 and MGEA5 genes on 1p22 and 10q24. This causes upregulation of the FGF8 gene, which can be visualized in some cases using immunohistochemistry for the antigen FGF8.…”

Recent Advances in the Diagnosis, Pathogenesis, and Management of Myxoinflammatory Fibroblastic Sarcoma

“…Radiographs may be normal or show a non-specific soft tissue mass without calcification. Although osseous erosion or invasion has been reported in only a few cases [14][15][16][17], the underlying bone is usually normal. Ultrasonography reveals a hypoechoic mass with lobulated margins [17].…”