Giant orf tumour in an immunocompromised patient

Recalcitrant giant orf recurrence after amputation: A case report and review of the literature

“…The antiviral, antiproliferative, and antiangiogenic properties of systemic interferon alfa-2a result in complete regression of the lesions, making it a suitable option for treatment of recalcitrant giant orf in immunocompromised patients. [13][14][15][16][17] In conclusion, immunocompromised patients may experience giant, persistent, and atypical lesions of orf disease. Our case highlights the importance of considering orf as a differential diagnosis, especially in immunocompromised patients complaining of a nodule or tumor-like lesions with a past history of close contact with animals such as sheep and goats or a history of cutting a body part through meat cleaning.…”

“…The antiviral, antiproliferative, and antiangiogenic properties of systemic interferon alfa‐2a result in complete regression of the lesions, making it a suitable option for treatment of recalcitrant giant orf in immunocompromised patients. 13 , 14 , 15 , 16 , 17 …”

Orf virus infection of human keratinocytes and dermal fibroblasts: Limited virus detection and interference with intercellular adhesion molecule‐1 up‐regulation

“…The main hosts are small ruminants, but the virus can readily infect broken skin of humans in close contact with diseased animals. The self‐limiting, benign disease resolves after several weeks, but in immunocompromised or young individuals, severe complications, such as secondary bacterial infections or “Giant Orf,” can occur . A pustular dermatitis with a mixed inflammatory infiltrate and hyperproliferation of keratinocytes are the main features of infection in animals and humans …”

“…The self-limiting, benign disease resolves after several weeks, but in immunocompromised or young individuals, severe complications, such as secondary bacterial infections or "Giant Orf," can occur. [5][6][7][8] A pustular dermatitis with a mixed inflammatory infiltrate and hyperproliferation of keratinocytes are the main features of infection in animals and humans. [8,9] This study identifies human primary keratinocytes (KC) and human primary dermal fibroblasts (FB) as susceptible for ORFV infection, however, with limited support for viral replication.…”

Rapidly Growing Nodule on the Finger of a 20-year-old Woman: A Quiz

“…However, it is well known that contagious ecthyma can trigger erythema multiforme (8). The disease is self-limiting and therefore does not usually require specific treatment (9-11), although there are several different treatment options, including cryotherapy, imiquimod, acyclovir and intralesional interferon injections (12)(13)(14). Local antiseptic treatment, however, is recommended to prevent bacterial super-infection.…”