Giant parathyroid adenoma presenting with multiple pathologic fractures: A case report

Abshirini, Hassan; Heidari, Mahsa; Fahimi, Ali; Ghorbani, Parastoo; Ghadirzadeh, Erfan; Shafiei, Shervin

doi:10.1002/ccr3.7474

Clinical Case Reports

2023

DOI: 10.1002/ccr3.7474

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Giant parathyroid adenoma presenting with multiple pathologic fractures: A case report

Hassan Abshirini

Mahsa Heidari

Ali Fahimi

et al.

Abstract: Hyperparathyroidism is a common endocrine disorder, which must be suspected in patients presenting with fatigue, history of pathologic fracture and the diagnosis can be confirmed by elevated calcium and PTH levels, and the preferred treatment option.

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2024

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Postoperative pancytopenia in a patient with giant parathyroid adenoma and brown tumor: a case report

Pan,

Zhao,

Wang

et al. 2024

BMC Endocr Disord

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Background Parathyroid adenoma is the primary cause of primary hyperparathyroidism, commonly presenting with elevated parathyroid hormone (PTH) and blood calcium levels. Chronic primary hyperparathyroidism often results in bone destruction, resulting in the formation of brown tumors. The preferred clinical treatment for parathyroid adenoma is parathyroidectomy. Postoperative pancytopenia, although rare, is a critical complication that warrants further investigation into its mechanisms and management strategies. Case presentation We present a case of a 59-year-old female patient who was admitted due to nausea and vomiting. Positron emission tomography-computed tomography (PET-CT) revealed a mass posterior to the left thyroid lobe and multiple areas of fibrocystic osteitis throughout the body. Hematological tests showed elevated serum calcium and parathyroid hormone (PTH) levels. The patient subsequently underwent parathyroidectomy, and pathological examination confirmed the presence of a parathyroid adenoma. Postoperatively, the patient developed pancytopenia and received symptomatic treatment such as correction of anemia and elevation of white blood. At the two-month follow-up, all indicators had returned to normal. Conclusions Pancytopenia is commonly seen in bone marrow diseases, infections and immune-related disorders, nutritional deficiencies, and metabolic diseases. This case confirms that pancytopenia can also occur postoperatively in patients with parathyroid adenoma. Therefore, Clinicians should be aware of the potential for postoperative pancytopenia following parathyroidectomy and the need for prompt management.

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Postoperative pancytopenia in a patient with giant parathyroid adenoma and brown tumor: a case report

Pan,

Zhao,

Wang

et al. 2024

BMC Endocr Disord

View full text Add to dashboard Cite

show abstract

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Giant parathyroid adenoma presenting with multiple pathologic fractures: A case report

Abstract: Hyperparathyroidism is a common endocrine disorder, which must be suspected in patients presenting with fatigue, history of pathologic fracture and the diagnosis can be confirmed by elevated calcium and PTH levels, and the preferred treatment option.

Cited by 1 publication

References 13 publications

Postoperative pancytopenia in a patient with giant parathyroid adenoma and brown tumor: a case report

Postoperative pancytopenia in a patient with giant parathyroid adenoma and brown tumor: a case report

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