Giant pyogenic granuloma of the thigh: a case report

Abstract

IntroductionPyogenic granuloma or lobular capillary hemangioma remains an etiopathological enigma, with trauma, inflammatory and infectious agents being the commonest suspected causative agents. These lesions affect mucous membranes of the upper aero-digestive tract, and skin. HIV patients diagnosed with pyogenic granuloma present with multiple lesions, caused by Bartonella spp.Case presentationA 28-year-old woman presented with a solitary large tumor on a skin graft donor site on her left thigh. On excision and histological examination the tumor was found to be a lobular capillary hemangioma (pyogenic granuloma). Further investigation in search of a possible explanation for this unusual presentation revealed HIV infection as the underlying cause.ConclusionThis report underscores the fact that the full spectrum of presentation of HIV infection is still unknown. Unusual or unexpected presentations should arouse suspicion of underlying immunosuppression, especially in HIV endemic areas.

Oral pyogenic granuloma presenting as an atypically large soft tissue mass: A case report

“…The lesion itself has been regarded as a non-neoplastic soft tissue lesion but recurrence after treatment has been observed in some cases [2,3,5,6,12]. The size usually varies from a few millimeters to several centimeters and rarely does PG exceed larger than 2 cm in size [2,3,5,6].…”

“…The lesion itself has been regarded as a non-neoplastic soft tissue lesion but recurrence after treatment has been observed in some cases [2,3,5,6,12]. The size usually varies from a few millimeters to several centimeters and rarely does PG exceed larger than 2 cm in size [2,3,5,6]. From the literature review, multiple PG and large PG which called giant PG were seldom reported in the oral cavity but those occur on other parts of the body such as extremities were commonly found and some cases were suggested to be related with immunocompromised patients [5,13].…”

“…The size usually varies from a few millimeters to several centimeters and rarely does PG exceed larger than 2 cm in size [2,3,5,6]. From the literature review, multiple PG and large PG which called giant PG were seldom reported in the oral cavity but those occur on other parts of the body such as extremities were commonly found and some cases were suggested to be related with immunocompromised patients [5,13]. However, three cases of intraoral giant PG reported by Tzung-Shiahn et al [10], Mubeen et al [11] and Panjwani et al [9] were not associated with host's immunity [9][10][11].…”

“…Other lesions occurring in the small bowel, colon, rectum and on burn scars have also been reported [2,5]. Clinically, PG reveals as a smooth or lobulated exophytic mass, either pedunculated or sessile.…”

“…PG has no malignant potential and recurrence after excision is not unusual [2,5,6]. Most reports suggest that PGs grow to a maximum size of 2 cm while lesions of larger size called "Giant pyogenic granuloma" were reported extraorally with the size larger than 4 cm [2,5,7]. In addition, there were few reports of intraoral PG with the size larger than 2 cm [8][9][10][11].…”