Giant retroperitoneal ganglioneuroma

Acín-Gándara, Débora; Carabias, A; Bertomeu, Alicia Bueno; Giménez-Alvira, L; Colao, L.; Limones, M.

doi:10.4321/s1130-01082010000300008

Cited by 10 publications

(8 citation statements)

References 4 publications

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“…As for predilection age, older children and young adults are found predominantly affected (14). It is suggested that GN was usually present in cases aged between 10 and 40 and that more than half of the patients were under 20 in a Japanese cohort (13,15). The age range of our cases is 15 to 62 with a mean age of 35, which may be affected by the fact that there is no pediatric surgery department in PUMCH.…”

Section: Discussionmentioning

confidence: 78%

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Xiao

Zhao

et al. 2021

Front. Surg.

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Purpose: To investigate the clinical characteristics, diagnosis, differential diagnosis, therapy options, and outcomes of retroperitoneal ganglioneuroma.Methods: In this retrospective study, we collected and analyzed the clinical data of 32 patients diagnosed with retroperitoneal ganglioneuroma and admitted to Peking Union Medical College Hospital from October 2012 to August 2019.Results: Among our 32 cases with retroperitoneal ganglioneuroma, the male-to-female ratio was 1:3 and the mean age was 35. Only 25% of the cases presented with abdominal pain while more than 65% had no specific symptoms. The masses could be found through physical examination in only five patients. Most of the tumors are located near the renal area. They were usually single and displayed an embedded growth pattern with diameters <10 cm, clear borders, and soft texture. For radiological imaging, the majority of tumors demonstrated soft tissue density with mild-to-moderate enhancement on CT imaging and showed hypoecho with moderate blood flow signals in ultrasound. No significantly abnormal laboratory examinations were found in most patients. Of all the 32 patients, 2 chose surveillance after biopsy due to difficulties in operation, while others chose surgical resection. The mean follow-up time was 15.8 months among 26 patients. The tumor remained stable in the surveillance cases. Residual tumors were found in four cases receiving operations with no progress and discomfort. No recurrence was seen in all patients.Conclusions: The retroperitoneal ganglioneuroma is a benign tumor without specific clinical manifestations or significant laboratory findings. Typically, it is shown as low density with a clear border and an embedded growth pattern in radiological imaging. The overall prognosis is good. Surgery is an effective approach with possible severe complications. Incomplete resection or surveillance can be considered for some cases where complete resection is difficult to achieve.

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Section: Discussionmentioning

confidence: 78%

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Xiao

Zhao

et al. 2021

Front. Surg.

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“…In our case, an ultrasound guided biopsy was done prior to going in for surgical resection to confirm the diagnosis. The treatment for retroperitoneal ganglioneuromas is surgery and they bear excellent prognosis following complete surgical excision [ 12 – 14 ]. Their close relationship with surrounding vital organs and inherent propensity of these tumors to surround blood vessels makes surgical excision of these tumors challenging [ 14 – 16 ] and may act as a limiting factor in complete surgical resection [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…The tumor measured 7 × 4 × 3 cm and was approached after mobilizing the left hemiliver and the structures of the portal triad were driven away from the right margin of the tumor after encircling the hepatoduodenal ligament using a Penrose drain. Acín-Gándara et al [ 12 ] reported the excision of a 15 cm retroperitoneal ganglioneuroma encompassing the celiac axis and superior mesenteric artery and extending from the right renal vein to the diaphragmatic hiatus using a midline laparotomy after mobilization of the pancreas and the liver.…”

Section: Discussionmentioning

confidence: 99%

Organ Preservation in a Case of Retroperitoneal Ganglioneuroma: A Case Report and Review of Literature

Kumar

Singh

Chandna

2016

Case Reports in Surgery

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The retroperitoneum is a closed space harbouring vital organs including the great vessels, kidneys and adrenal glands, ureters, and the ascending and descending colon. Surgical management of retroperitoneal pathologies may need multiorgan resection in order to achieve complete surgical resection while preservation of surrounding organs should be attempted, especially in case of benign tumors. We present a case of 15-year-old girl with an 11 × 6 × 5 cm retroperitoneal ganglioneuroma displacing the right kidney, renal vein, and ureter and abutting the IVC which was excised in toto preserving the right kidney and ureter with careful dissection around the great vessels. We also attempt to review the various surgical options available while dealing with these benign retroperitoneal tumors which are often detected incidentally and usually surround important retroperitoneal organs and vessels.

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“…There are only four articles about ganglioneuroma during pregnancy in English on PubMed (Table 1) [9,10,11,12]. Patients in the articles had no symptoms, had incidental detection of their tumors, and underwent resection of the mass.…”

Section: Discussionmentioning

confidence: 99%

Incidentally detected ganglioneuroma during pregnancy: A case report

Kim

et al. 2014

Obstet Gynecol Sci

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Retroperitoneal ganglioneuroma is a rare benign tumor, which is included in the neuroblastomas group. It can occur anywhere along the peripheral autonomic ganglion sites, and the tumor is often incidentally detected in asymptomatic patients or may produce symptoms related to the slow growing tumor. Surgical excision is the treatment of choice and the prognosis is good. We report a case of retroperitoneal ganglioneuroma, which was incidentally detected in the first trimester of pregnancy in a 29-year-old woman. Surgical resection of the ganglioneuroma was done at the time of cesarean section at full term without complications.

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Giant retroperitoneal ganglioneuroma

Cited by 10 publications

References 4 publications

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Organ Preservation in a Case of Retroperitoneal Ganglioneuroma: A Case Report and Review of Literature

Incidentally detected ganglioneuroma during pregnancy: A case report

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