Giant Retroperitoneal Lymphangioma: a Rare Entity

Suhani,; Aggarwal, Lalit; Ali, Shadan; Thomas, Shaji

doi:10.1007/s12262-013-0989-y

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…The etiology of lymphangiomas remains uncertain, but congenital lymphatic malformations leading to sequestration of lymphatic tissue appear to be the primary cause[ 8 ]. Most commonly found in children under 2 years of age, incidence rates are reported to be roughly 1.2-2.8 per 100000[ 1 ]; adult cases are extremely rare.…”

Section: Discussionmentioning

confidence: 99%

“…Most commonly found in children under 2 years of age, incidence rates are reported to be roughly 1.2-2.8 per 100000[ 1 ]; adult cases are extremely rare. Lymphangiomas may be classified as capillary, cystic, or cavernous depending on their histologic characteristics[ 8 ], and frequently present as benign masses in the head and neck region. Other regions of incidence include the axilla (20%) and intra-abdomen (less than 5%), with retroperitoneal lymphangiomas representing less than 1% of all lymphangiomas[ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Because lymphangiomas are mostly asymptomatic until they grow into considerable size, they pose a difficult challenge in terms of pre-operative diagnosis[ 6 ]. Differential diagnosis for retroperitoneal cystic lymphangioma is diverse, ranging from benign tumors from the pancreas or kidney to malignant tumors including teratoma, undifferentiated sarcoma, and cystic metastases from stomach or ovary; peri-pancreatic cysts must also be differentiated[ 8 ]. Often, the only symptom of a retroperitoneal lymphangioma will be a slowly growing, palpable abdominal mass.…”

Section: Discussionmentioning

confidence: 99%

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Surgical excision of a large retroperitoneal lymphangioma: A case report

Park¹,

Lee²,

Maeng³

et al. 2022

World J Clin Cases

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BACKGROUND Lymphangiomas are rare benign tumors most commonly found in children under 2 years of age; adult cases are extremely rare. Retroperitoneal lymphangiomas represent less than 1% of all lymphangiomas. Because of their benign nature and possibility of spontaneous resolution, lymphangiomas are sometimes left untreated for long periods of time. However, if they grow large enough to compress surrounding structures, retroperitoneal lymphangiomas may cause symptoms such as abdominal pain, nausea or vomiting. We report a case of a rapidly growing retroperitoneal lymphangioma in an adult, treated with complete surgical excision. CASE SUMMARY A 60-year-old female who was diagnosed with an intra-abdominal cystic mass (11 cm × 9.5 cm) seven years ago presented to our hospital with symptoms of early satiety, nausea, and intermittent abdominal pain. Computed tomography (CT) scan confirmed interval enlargement to a 24 cm × 22 cm-sized huge left retroperitoneal mass, causing left hydronephrosis by external compression. Laparotomy was done via long midline incision. Due to severe adhesion between the aorta and the medial border of the mass, the cyst was intentionally opened for fluid aspiration and size reduction. After suture closure of the opening, we proceeded carefully with dissection. Aspiration showed light yellowish serous fluid. The mass was excised completely, and the pathology was consistent with cystic lymphangioma. The post-operative period was uneventful, and the patient was discharged without complications. Follow-up CT scan one month after surgery confirmed complete removal of the mass and decreased left hydronephrosis. CONCLUSION Excision of the huge retroperitoneal cystic mass resulted in relief of the patient’s symptoms, originally caused by external compression, and also ruled out the possibility of malignancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Surgical excision of a large retroperitoneal lymphangioma: A case report

Park¹,

Lee²,

Maeng³

et al. 2022

World J Clin Cases

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“…Melanomas with BRAF mutations exhibit heightened aggressiveness compared to those with wild-type BRAF, often showing a greater tendency to metastasize to the brain, while metastasis to the brain is the primary cause of death in melanoma, occurring in 95% of cases [ 2 ]. Brain metastasis typically manifests relatively late in the disease course (stage IV), with a median interval of 2.2-3.8 years following the initial diagnosis [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome-Based Treatment for Melanoma With Brain Metastasis: A Case Report

Ayass,

Melendez,

Griko

et al. 2024

Cureus

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Malignant melanoma with brain metastasis has a high mortality rate. New approaches for diagnosis and treatment are urgently required to improve prognosis. Here we present a 60-year-old male with metastatic melanoma to the brain. Using a transcriptomics pipeline, we analyzed whole blood and resected tumor tissue, identifying enriched gene expression biomarkers and pathways - including seven upregulated ( BRAF, CDK4, EIF1AX, IK, NRAS, PIK3R2, and TP53) and 11 downregulated (CASP8, CDK10, CDKN2A, CTLA4, GNA11, HERC2, IRF4, MC1R, PLA2G6, RREB1, and TPCN2) genes in the blood (across 15 pathways), showing 14% enrichment, and 16 upregulated (CCND1, CDK4, CTLA4, EIF1AX, IK, IRF4, MITF, NRAS, PIK3CB, PIK3R2, PMEL, RREB1, SLC45A2, SOX10, TYR, and TYRP1) and three downregulated ( GNA11, KITLG, and PLA2G6) genes in tissue (across 17 pathways), showing 33% enrichment, with five shared markers and 12 shared pathways. The model connected CDK4 pathway overactivity observed in both samples to inhibitors like ribociclib, abemaciclib, and palbociclib as putative treatments. By enabling objective personalized therapy selection, this approach shows great promise for advancing patient outcomes.

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“…The tumor is commonly confused with other retroperitoneal cystic tumors, including cystic tumors caused by the kidney and pancreas. [2] Depending on the location, it may be misdiagnosed as pancreatic pseudocyst, ovarian cyst, renal cyst or other diseases. [3] Patients with retroperitoneal lymphangiom usually lack specific symptoms, and most of them are found by accident.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of adult retroperitoneal lymphangioma: a single center Chinese cohort study of 15 cases

Liu,

Zhong,

Zheng

2024

Preprint

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Background Lymphangioma is a rare cystic tumor that occurs across different locations. Retroperitoneal lymphangioma accounts for about 1% of all lymphangiomas. In this study, we report the clinicopathological features of retroperitoneal lymphangioma and describe our experience in treating this disease. Methods We collected clinical data from all patients who were pathologically diagnosed with retroperitoneal lymphangioma at Zhejiang Provincial People's Hospital, between June 2013 and August 2022. Results The 7 and 8 male and female patients analyzed herein had a mean age of 48.6 (SD 14.24) years at diagnosis. The mean duration of follow-up was 4.7 years. Among them, 66.67% were asymptomatic, with the rest manifesting abdominal pain, nausea, low back pain and elevated blood pressure as the main symptoms. Preoperative diagnosis and evaluation of cysts were mainly performed via Computed Tomography(CT)(n = 10, 66.67%) or magnetic resonance imaging༈MRI༉ (n = 8, 53.33%). All patients were completely resected following surgery. Immunohistochemical analysis, performed on 6 patients, revealed that they were positive for D2-40. A total of 4, 4 and 3 patients were positive for CD31, CD34 and SMA, respectively. Moreover, the study cohort had an average postoperative hospital stay of 6.6 days. Follow up, after the end of the study, revealed no relapse in any of the 15 patients. Conclusions Lymphangioma is a benign tumor of the lymphatic system. Although typical imaging features can be accurate for preoperative diagnosis, histological examination is crucial to final confirmation. Complete surgical resection is the best option to limit the risk of recurrence in cases with symptomatic lesions.

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Giant Retroperitoneal Lymphangioma: a Rare Entity

Cited by 7 publications

References 6 publications

Surgical excision of a large retroperitoneal lymphangioma: A case report

Surgical excision of a large retroperitoneal lymphangioma: A case report

Transcriptome-Based Treatment for Melanoma With Brain Metastasis: A Case Report

Characteristics of adult retroperitoneal lymphangioma: a single center Chinese cohort study of 15 cases

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