Giant Secondary Overgrowth of Type-1 Pulmonary Cystic Airway Malformation Upon Development of Anaplastic Lymphoma Kinase–Rearranged Adenocarcinoma

Abstract

We herein report on a giant secondary overgrowth of type-1 pulmonary cystic airway malformation (PCAM) occurring upon development of ALK receptor tyrosine kinase (ALK)-rearranged adenocarcinoma as documented from imaging, pathology, immunohistochemistry, and fluorescence in situ hybridization (FISH) for ALK. PCAMs, formerly known as congenital cystic ade-*Corresponding author.