Giant secretory multifocal adrenal myelolipoma: a diagnostic dilemma

Singh, Brijesh Kumar; Arumugaswamy, Prasanna Ramana; Chumber, Sunil; Rathore, Yashwant Singh

doi:10.1136/bcr-2020-239441

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Adrenal myelolipoma is a rare tumor with fat density under the CT scan and is clinically relevant. Because of the advancement of imaging technology and its popularization, reports of AML have been increased during the last decades (5,(9)(10)(11)(12)(13)(14). There exists a dilemma that diagnosis of AML is difficult because of its benign properties and reliability of the pathological examination.…”

Section: Discussionmentioning

confidence: 99%

Adrenal Myelolipoma: 369 Cases From a High-Volume Center

Lin

Gong

Cheng

et al. 2021

Front. Cardiovasc. Med.

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Background: Adrenal myelolipoma (AML) is a nonfunctional benign neoplasm from the adrenal cortex, composed of mature fat and hematopoietic tissue. Usually, patients have no symptoms. However, some patients with hypertension and blood pressure normalize after AML surgery, indicating some connections between AML and hypertension.Materials and Methods: This was a retrospective cohort study of 369 patients diagnosed with AML from September 2008 to December 2018 collected in the Urology Department of West China Hospital, Chengdu, Sichuan, China. We collected clinical records of patients before surgery. Postoperative follow-up was also carried out for those with hypertension and whether patients needed to take antihypertensive drugs and postoperative blood pressure were recorded. We aim to explore the characteristics of both patients with AML having hypertension and having remission of hypertension in 1 year after surgery.Results: There were 369 patients with AML included in the study, 156 men and 213 women, aged 49.86 ± 11.61 years old. Among them, 121 (32.8%) patients presented with hypertension. Body mass index was significantly higher in the hypertension group than that in the nonhypertension group, even after adjusting other variables (26.26 ± 3.43 vs. 24.28 ± 3.38 kg/m2, P < 0.001 for both univariate and multivariate analyses). Sixty patients were followed up for 1–9 years, with a median follow-up of 52 months. The duration of hypertension in the remission group was shorter than that in the non-remission group (P = 0.020), and the tumor lateralization was significantly different between the two groups (P = 0.005).Conclusions: Nearly one-third of patients with AML suffered from hypertension in our study, and there existed some potential links between AML and hypertension. To be more specific, AML-related hypertension was more likely to result from obesity and renal compression by perirenal fat than from endocrine disorders or blood vessels compression. Patients with AML and with more than 3 years of hypertension might have less possibility to recover.

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Section: Discussionmentioning

confidence: 99%

Adrenal Myelolipoma: 369 Cases From a High-Volume Center

Lin

Gong

Cheng

et al. 2021

Front. Cardiovasc. Med.

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“…The coexistence of IAM and pheochromocytoma is an exceptionally rare occurrence [22,23]. In a study conducted by Decman in 2018, only two cases of IAM accompanying pheochromocytoma were reported [4].…”

Section: Discussionmentioning

confidence: 99%

A Single-Center Experience of Special Cases: Adrenal Myelolipoma and Adrenal Adenoma with Myelolipoma Component

Cetin,

Erten,

Sen

et al. 2024

Preprint

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Isolated adrenal myelolipoma (IAM) is a benign neoplasm of the adrenal gland and is the second most common primary adrenal tumor following adrenocortical adenomas. Another type of adrenal tumor formation is known as adenoma with myelolipoma component (AMC). This study aims to retrospectively compare IAM and AMC cases in a single institution, focusing on special clinical and pathologic features, and comparing coincidences with the literature. According to our study, IAM and AMC have similar entities; including histopathological findings and cover similar comorbidities. However, due to all the remaining features soon to be discussed; we suggest that these two tumors should be studied under different headings.

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Catecholamine-Secreting Adrenal Myelolipoma in the Absence of Hypertension: A Rare Case Report

Jain,

Daksh,

Ranjan

et al. 2024

IJEM Case Rep

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Adrenal myelolipoma (AML) is a benign neoplasm of the adrenal gland composed of fat and myeloid components. Most of these tumors are asymptomatic and non-secretory. We describe the case of a 22-year-old female who was being evaluated for right abdominal flank pain. She was detected with a 7.1 × 5.2 cm right adrenal mass with −55 mean HU on computed tomography (CT) scan, suggestive of myelolipoma. Her 24-hour urine normetanephrine level was elevated. Regular blood pressure monitoring was carried out, but she was normotensive. Right-sided unilateral adrenalectomy was performed. Histopathologic analysis confirmed the diagnosis of adrenal myelolipoma. Urine normetanephrine levels normalized post-surgery. Very few cases of catecholamine secretion by AML have been described in the literature. All of these cases had hypertension. To the best of our knowledge, this will be the first case reporting catecholamine secretion by AML in a normotensive patient.

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Giant secretory multifocal adrenal myelolipoma: a diagnostic dilemma

Cited by 3 publications

References 9 publications

Adrenal Myelolipoma: 369 Cases From a High-Volume Center

Adrenal Myelolipoma: 369 Cases From a High-Volume Center

A Single-Center Experience of Special Cases: Adrenal Myelolipoma and Adrenal Adenoma with Myelolipoma Component

Catecholamine-Secreting Adrenal Myelolipoma in the Absence of Hypertension: A Rare Case Report

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