Giant solitary fibrous tumor of the lung: A case report

Xiao, Ping; Sun, Linlin; Zhong, Diansheng; Lian, Linjuan; Xu, Dongbo

doi:10.1111/1759-7714.12069

Cited by 3 publications

(3 citation statements)

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“…In addition, Snail protein stability is finely controlled by GSK3b-dependent phosphorylation and ubiquitination. 18 We also found AEC PQ-exposure could decrease the level of GSK-3b, while the level of GSK-3b was increased after silencing LOX and inactivating LOX. We guessed that PQ-induced LOX could indirectly affect Snail by decreasing the expression of GSK-3b; however, the mechanism is unclear.…”

Section: Discussionmentioning

confidence: 57%

“…It also had been shown to carry out intracellular functions beyond extracellular cross-linkage, including cell migration, cell polarity and EMT. 18 Jansen MK demonstrated that the expression of intracellular LOX was up-regulated after the induction of EMT in MDCK II cells. 19 Both the Cu(II) cofactor and the lysyl-tyrosylquinone cofactor are required for the oxidase activity.…”

Section: Discussionmentioning

confidence: 99%

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Lysyl oxidase promotes epithelial-to-mesenchymal transition during paraquat-induced pulmonary fibrosis

et al. 2016

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Lysyl oxidase (LOX) is a copper-dependent amine oxidase that plays a critical role in pulmonary fibrosis. Our previous study demonstrated that epithelial-to-mesenchymal transition (EMT) was strongly associated with paraquat (PQ) induced pulmonary fibrosis. This present study was aimed to evaluate the potential involvement of LOX on EMT in the process of pulmonary fibrosis induced by PQ. We established an in vivo rat model and an in vitro cell model induced by PQ treatment and found that LOX protein expression was significantly up-regulated and collagen deposition was enhanced in rats. The EMT process was strongly found in A549 and RLE-6TN cells after PQ exposure. After inactivating LOX with an inhibitor, pulmonary fibrosis was significantly reduced and EMT was also suppressed. Additionally, small interfering RNA (siRNA) targeting LOX was used to silence LOX expression to observe EMT in A549 cells. As a result, LOX could promote the progress of EMT, and inactivating LOX alleviated the EMT process in PQ-induced pulmonary fibrosis and mesenchymal-to-epithelial transition (MET) occurred after inactivating LOX in vitro and in vivo. In conclusion, LOX could promote the progress of EMT and inactivating LOX alleviated EMT in PQ-induced pulmonary fibrosis. Therefore, LOX could potentially be a new candidate therapeutic target for pulmonary fibrosis induced by PQ by regulating the balance between EMT and MET.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Lysyl oxidase promotes epithelial-to-mesenchymal transition during paraquat-induced pulmonary fibrosis

et al. 2016

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“…28 LOX family proteins also play a role in epithelial mesenchymal transformation, which is believed to affect cell movement, tumour invasion and metastasis. While these post-translational crosslinks are benecial for added stability of the ECM, overexpression and unusual LOX activity also lead to disorders of the connective and brotic tissue, 29 and are reported as being risk factors for diseases including ovarian cancer. 30 Tryptophan tryptophylquinone (TTQ).…”

Section: Quinonesmentioning

confidence: 99%

Unusual post-translational protein modifications: the benefits of sophistication

Ravikiran

Mahalakshmi

2014

RSC Adv.

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Solitary Fibrous Tumors of the Lung: A Clinicopathological Analysis of 52 Cases

et al. 2023

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Objective: To explore the clinicopathological features of solitary fibrous tumors (SFTs) of the lung. Methods: We collected the clinical data of 52 patients with SFTs of the lung confirmed by pathology, and summarized the clinical, radiological, and morphological features, the immunophenotypes, and the prognosis of SFTs. Results: Fifty-two cases of SFTs of the lung were enrolled in this study, including 51 cases of borderline and 1 case of malignancy, 22 males and 30 females. The average onset age was 52.7 years. The lower lobe of the left lung was the preferred site of SFTs, accounting for 30.77% (16/52). Chest CT showed regular and well-demarcated soft tissue density mass, and the tumor size of most cases (46/52, 88.46%) was 1–10 cm. Morphological features: The distribution of tumor cells showed sparse and dense areas. Tumor cells were spindle-shaped, in whorls or hemangiopericytoma-like conformation. Atypia, mitotic figures, and necrosis were found. Immunohistochemistry showed positive expression of CD34, STAT6, Vimentin, BCL2, and CD99. Ki-67 was ≤ 5% in borderline SFTs and > 20% in a malignant SFT. Conclusions: Solitary fibrous tumors of the lung occur more frequently in middle-aged and elderly people, and there is no significant difference in gender. The lower lobe of the left lung is the preferred site of SFTs. The size of most SFTs is 1–10 cm. Chest CT shows morphologically regular and well-demarcated soft tissue density mass. Pathologically, SFTs of the lung are mostly borderline and occasionally malignant. Immunohistochemistry shows the positive expression of CD34, STAT6, Vimentin, BCL2, and CD99.

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Giant solitary fibrous tumor of the lung: A case report

Abstract: Keywords AbstractA solitary fibrous tumor arising from the lung parenchyma is rarely described. Here, we present the clinical, imaging, and histological features of a case of a 54-year-old woman with an incidental lung mass of the right lower lobe on a chest radiograph.

Cited by 3 publications

References 10 publications

Lysyl oxidase promotes epithelial-to-mesenchymal transition during paraquat-induced pulmonary fibrosis

Lysyl oxidase promotes epithelial-to-mesenchymal transition during paraquat-induced pulmonary fibrosis

Unusual post-translational protein modifications: the benefits of sophistication

Solitary Fibrous Tumors of the Lung: A Clinicopathological Analysis of 52 Cases

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