Giant Solitary Fibrous Tumor of the Pleura Causing Respiratory Insufficiency: Report of 3 Cases

A Large Solitary Fibrous Tumor of the Pleura Associated with Massive Pleural Effusion: A Case Report and Review of the Literature

“…To date, there are no certain morphological characteristics that predict a poor prognosis of SFTP [11][12][13]. The usual age at diagnosis is 60 or 70 years, and it occurs in similar frequency in both sexes [3]. Our patient is a female in her forties with a large amount of serous pleural effusion, although existing case series report pleural effusion in less than 10% of cases; furthermore, some studies suggest an association with malignant potential [5,14].…”

“…The onset of illness can be completely asymptomatic, and the tumor is usually discovered incidentally; more commonly, however, patients present with respiratory symptoms, including severe respiratory distress. In rare cases, the tumor can present with significant metabolic derangement such as hypokalemia and hypoglycemia, collectively known as Doege-Potter syndrome [3,4]. Most solitary fibrous tumors are benign, and only 20% are not [5].…”

CT diagnosis and differentiation of benign and malignant varieties of solitary fibrous tumor of the pleura

“…Large tumors may compress the trachea and lung tissue, causing cough, chest tightness, dyspnea, and even respiratory insufficiency. [ 14 – 17 ] Chest pain is common when the tumor arises from the parietal pleura, and if the tumor invades adjacent tissue structures and erodes lung tissue or ribs and nearby nerves, chest pain is more severe and hemoptysis may occur. Robinson [ 18 ] reported that about 10% of their SFTP study patients developed paraneoplastic syndromes, such as hypertrophic osteoarthropathy, hypoglycemia, clubbed nailbeds, and gynecomastia or galactorrhea.…”

“…[ 21 ] Benign lesions may also recur and metastasis, and histopathological results cannot definitively exclude malignancy; therefore, long-term follow-up is necessary for all surgical patients. [ 14 , 22 ]…”

Solitary Fibrous Tumor – Less Common Neoplasms of the Pleural Cavity

“…Nevertheless, up to half of the cases present themselves through their clinical manifestation. 7,[13][14][15] The symptoms may either be intrathoracic due to the suppression of the lung as a result of tumor growth, or by formed pleural effusion, as well as extrathoracic due to the production of specific substances by cancer cells proper. 5) The most common intrathoracic symptoms are coughing, chest pain, dyspnoea and haemoptysis.…”