Giant versus regular parathyroid adenoma: A retrospective comparative study

Al-Gargaz, Wisam; Abushukair, Hassan; Odat, Haitham; Hamouri, Shadi; Abuashour, Raneem

doi:10.1016/j.amsu.2021.102454

Cited by 1 publication

(2 citation statements)

References 28 publications

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“…Parathyroid adenomas (PTA) have been described to be the cause for up to 85% of PHPT [ 3 ]. A PTA with a weight of >3.5 g are classified as giant parathyroid adenomas (GPTA) [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Giant Parathyroid Adenoma-Associated Fracture, Not All Lytic Bone Lesions are Cancer: A Case-Based Review

Álvarez-Payares

Ribero

Ramírez-Urrea

et al. 2022

Case Reports in Medicine

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Introduction. Due to the early diagnosis of primary hyperparathyroidism the musculoskeletal manifestations of this disease are becoming less frequent. When this disease manifests secondary to a giant adenoma, it presents with more aggressive symptoms and can have important repercussions such as the hungry bone syndrome after parathyroidectomy. There are few reported cases of hyperparathyroidism secondary to a giant adenoma in the literature, as the presence of a brown tumor is often misinterpreted as a metastatic lesion from an unknown primary tumor. Methods. We describe a case and performed a literature review to identify all case reports. A literature search was carried out on PubMed/MEDLINE and EMBASE bibliographic databases. All available studies from May 2009 to May 2021 were included. Data were tabulated, and outcomes were cumulatively analyzed. Results. Twenty-four cases of primary hyperparathyroidism due to giant adenoma have been described; the majority were women, with a mean age of 52 years. They presented with heterogeneous symptoms such as palpable nodules (45%), bone pain (33%), brown tumor (12.5%), asymptomatic (12.5%), metabolic profile with a mean calcemia of 13.8 mg/dL, PTH 1109 ng/L, and mean tumor weight of 47.24 g. Conclusion. Primary hyperparathyroidism due to giant adenoma increases the risk of developing potentially serious postoperative complications such as hungry bone syndrome. This implies the need of implementing preventive measures comprising administration of intravenous zoledronic acid and early supplementation of oral calcium to prevent complications after resection.

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“…Parathyroid adenomas (PTA) have been described to be the cause for up to 85% of PHPT [ 3 ]. A PTA with a weight of >3.5 g are classified as giant parathyroid adenomas (GPTA) [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Parathyroid adenomas (PTA) have been described to be the cause for up to 85% of PHPT [ 3 ]. A PTA with a weight of >3.5 g are classified as giant parathyroid adenomas (GPTA) [ 3 , 4 ]. However, it is important to note that the measurement may only be obtained after surgical excision, which is an additional diagnostic challenge.…”

Section: Introductionmentioning

confidence: 99%