Giant villous adenoma presenting as a mass protruding from the rectum in a 29-year-old female patient

Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature

“…5–14 cm or 99 cm 2 -Villous adenoma-Villous adenoma with high-grade dysplasia and intramucosal carcinoma-Villous adenoma with low-grade dysplasia4.Agnes A, Novelli D et al [15]9 cmVillous adenoma with areas of intramucosal adenocarcinoma and high-grade dysplasia5.Challis BG, Lim CT et al [16]10 cmTubulovillous adenoma exhibiting moderate to low-grade dysplasia6.Okano M, Okuyama M et al [17]10 cm7.Mois EI, Graur F et al [18]14 cmLow-grade dysplasia with focal high-grade dysplasia8.Nakhla SG, Murakami TT et al [19]17 cmLarge rectal villous adenoma coexistent with a poorly differentiated neuroendocrine tumor of the rectum9.Kure K, Kawai M et al [20]12.7 × 11.5 cmMostly tubulovillous adenoma, but partially moderately differentiated adenocarcinoma.10.Das P, Vijay MK et al [21]8.5 × 6 × 4 cmGiant villous adenoma with low-grade dysplasia11.Ohtsuka M, Hata T et al [22]Concurrent adenocarcinoma12.Roriz-Silva R, Andrade AA et al [23]14 cmVillous adenoma with low-grade atypia13.Aboul Hosn M, Abdel-Hafiez N et al [24]12 cmNo evidence of invasive carcinoma14.Barendse RM, van den Brandt S et al [25]9 cmVillous adenoma with focal high-grade dysplasia15.Choi WH, Ryuk J et al [26]25 cm × 12 cmWell-differentiated adenocarcinomas arising in villotubular adenomas16.Tuţă LA, Boşoteanu M et al [27]12 × 10 cmWell-differentiated adenocarcinoma arising within a villous adenoma.17.Dagan A and Reissman P [28]. 31 cmLow- to high-grade dysplasia18.Cubuk R, Tasali N et al [29]17 × 9 cmVillous adenoma without high-grade dysplasia19.Koning GG, Rensma PL et al [30]15 × 8Low-grade dysplasia20.Nagri S, Eskaros S et al [31]8 × 5 × 4 cmGiant villous adenoma with high-grade dysplasia…”