Giardia duodenalis: The double-edged sword of immune responses in giardiasis

Resistance to reinfection in mice as a vaccine model for giardiasis

“…The role of mast cells in elimination of primary Giardia infections in mice and gerbils has been described previously. 3,23 Interestingly, the number of mast cells in the mucosa returns to pre-infection levels by ~60 d after the primary infection, but the mice were significantly protected against challenge infections. This suggests that mast cells are not responsible for mediating protection against challenge infection.…”

“…3 We therefore examined mast cell responses following infection. Figure 4 shows that priming of wild-type mice leads to a significant accumulation of mast cells 26 d later.…”

“…Since CD4 + T cell responses have been shown to be important for control of primary infections, 3 we then sought to examine cytokine production by these cells. We have recently reported that MLN and spleen T cells produced similar patterns of cytokines following in vitro stimulation with parasite extracts.…”

“…G. lamblia, G. intestinalis) affects hundreds of millions of people in both the developed and developing worlds (reviewed in refs. [1][2][3]. Infections result in a range of outcomes including severe diarrhea, nutrient malabsorption, cognitive and developmental defects as well as sub-clinical infections.…”

Desvendando a resposta dos eosinófilos, dos neutrófilos e dos monócitos nas parasitoses intestinais, na asma e na associação de ambas em crianças

“…Os fagócitos mononucleares são importantes células na defesa do organismo contra a Giardia (Hill & Pearson, 1987). Os monócitos, macrófagos e granulócitos atuam também na destruição dos trofozoítos por meio de reações de citotoxicidade anticorpo-dependentes (Kohli, Bushen, Pinkerton, et al, 2008;Solaymani-Mohammadi & Singer, 2010;Stark, Barratt, Van Hal, et al, 2009). …”