Gicht und Calciumpyrophosphat-Dihydrat-Arthropathie („Pseudogicht“) – ein Update

Reuß‐Borst, Monika; Tausche, Anne‐Kathrin

doi:10.1055/a-0504-5684

Cited by 8 publications

(4 citation statements)

References 21 publications

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“…Кроме того, и подагра, и болезнь депонирования кристаллов пирофосфата кальция могут сочетаться как между собой, так и с другими ревматическими заболеваниями, что еще больше затрудняет своевременную верификацию диагноза [22,23]. В научной литературе описаны схожие с этим клинические случаи, когда хронический артрит как при подагре, так и при болезни депонирования кристаллов пирофосфата кальция симулирует симптомы ревматоидного артрита [24,25].…”

Section: Discussionunclassified

The course of gout in a patient with Cushing’s disease after successful surgical treatment

Dzeranova

Елисеев²,

Golounina

et al. 2023

Obes. metabol.

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Endogenous hypercortisolism is a severe endocrine disease characterized by prolonged exposure to excessive amounts of glucocorticoid hormones, accompanied by a wide range of symptoms and complications, including immunosuppression. Timely surgical treatment in most cases allows to save the patient’s life, significantly improve its quality. However, restoration of the normal concentration of glucocorticoid hormones can become a trigger factor in the development or exacerbation of autoimmune and auto-inflammatory diseases. We present a clinical case of atypical gout in a patient with hypercortisolism and a progressive increase in symptoms of the disease after successful surgical treatment for Cushing’s disease and achieving stable remission. The issues of diagnosis and treatment of this group of autoinflammatory diseases are highlighted, the leading clinical and radiological symptoms are considered, the differential diagnosis of microcrystalline (metabolic) arthritis is presented. Despite the widespread, the diagnosis and treatment of this group of diseases still cause difficulties for specialists. A competent choice of drug therapy allows to fully control diseases considered in the article, including when they are combined, and thereby improve the quality of life of the patient.

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Section: Discussionunclassified

The course of gout in a patient with Cushing’s disease after successful surgical treatment

Dzeranova

Елисеев²,

Golounina

et al. 2023

Obes. metabol.

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“…As both crystal diseases are mediated by IL-1-driven processes, the therapeutic intervention first targets acute inflammation consisting of Colchicine, NSAIDs, and glucocorticoids. 43 …”

Section: Discussionmentioning

confidence: 99%

“…Tocilizumab improved disease activity in all patients after 3 months-treatment but had some adverse effects. 43 …”

Section: Discussionmentioning

confidence: 99%

Lumbar Spinal Involvement in Calcium Pyrophosphate Dihydrate Disease: A Systematic Literature Review

Tekaya¹,

Nacef²,

Bellil³

et al. 2022

IJGM

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Background Calcium-pyrophosphate-dihydrate-disease (CPPD) is a crystal-induced arthropathy. The lumbar-spinal involvement is rare and often under-diagnosed. This study aimed to report the case of a lumbar spine CPPD involvement and to perform a systematic review of clinical, imaging features of lumbar involvement in CPPD patients, and treatments that have been implemented. Methods This systematic review was conducted in accordance with the Preferred-Reporting-Items-for-Systematic-Reviews and Meta-Analyses (PRISMA) guidelines. Results One hundred and sixty-seven articles met the search criteria using electronic databases searches. We retained 28 articles (20 case reports, 2 case series, 1 family survey, 4 retrospective studies, and 1 prospective study) involving a total of 62 patients. The age ranged between 39 and 89 years old. Among patients with lumbar spine CPPD, 32 were women. The duration of symptoms varied between one day and 8 years. The affection has been discovered during back pain in most cases. In 5 studies, the diagnosis was made on histological specimens of patients operated on for another pathology. X-ray showed calcifications in 2 cases. CT-scan detected calcium deposit in 7 cases. MRI showed lesions going from the increased signal of the disk, to calcified or not-cystic lesion of the facet joints, an intramedullary mass mimicking a schwannoma. Histological examination established the diagnosis of CPPD in 21 patients in all studies. Medical treatment included NSAIDs, Colchicine, Interleukin-1-receptor-antagonist, and antibiotics. Surgery was performed on 13 patients and allowed to establish the histological diagnosis. Conclusion In the case of inflammatory back pain in elderly subjects, without an infectious gateway, diagnosis of CPPD should be considered, especially for patients with a history of spinal surgery or degenerative radiography changes. CT scan is more sensitive than conventional radiographs. The discovertebral biopsy is the Gold-Standard and should be performed whenever the diagnosis was uncertain. Treatment includes the medical and surgical components.

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“…Новая парадигма СНсСФВ идентифицирует вызванное сопутствующими заболеваниями системное воспаление как причину структурных и функциональных изменений миокарда. Предполагается, что одной из причин СН является воспаление [2], характерное для многих ревматических заболеваний, в том числе микрокристаллических артритов [3].…”

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Diastolic dysfunction of ventricles in patients with calcium pyrophosphate crystal deposition disease while receiving anti-inflammatory therapy

Елисеев

Zhelyabina

Kirillova

et al. 2023

Terapevticheskii arkhiv

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Background. Calcium pyrophosphate crystal deposition disease (CPPD) may be associated with developing of diastolic dysfunction (DD). Aim. To determine the variability of echocardiographic parameters in patients with CPPD receiving anti-inflammatory therapy. Materials and methods. Twenty six patients with CPPD and osteoarthritis (OA) from 18 to 65 years old were included in the case-control study. All patients underwent echocardiography, laboratory parameters at baseline and after 6 months. Patients with CPPD received methotrexate 15 mg per week or hydroxychloroquine 200 mg once a day, or colchicine 1 mg per day. Diastolic function according to echocardiography was assessed. Results. Diastolic dysfunction was detected in 19 patients: in 11 (42%) patients with CPPD and 8 (31%) patients with OA (p=0.39). The baseline serum CRP level was higher in the CPPD group (p=0.03), no differences were found for other indicators. Twenty-two patients with CPPD and 19 patients with OA completed the study. In patients with OA, there were no significant changes in indicators reflecting the diastolic function of ventricles. Conclusion. CPPD therapy with colchicine, hydroxychloroquine and methotrexate has a positive effect on indicators of diastolic ventricular function.

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Gicht und Calciumpyrophosphat-Dihydrat-Arthropathie („Pseudogicht“) – ein Update

Cited by 8 publications

References 21 publications

The course of gout in a patient with Cushing’s disease after successful surgical treatment

The course of gout in a patient with Cushing’s disease after successful surgical treatment

Lumbar Spinal Involvement in Calcium Pyrophosphate Dihydrate Disease: A Systematic Literature Review

Diastolic dysfunction of ventricles in patients with calcium pyrophosphate crystal deposition disease while receiving anti-inflammatory therapy

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