2014
DOI: 10.1021/np5004966
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Giffonins A–I, Antioxidant Cyclized Diarylheptanoids from the Leaves of the Hazelnut Tree (Corylus avellana), Source of the Italian PGI Product “Nocciola di Giffoni”

Abstract: Eight new diaryl ether heptanoids, giffonins A-H (1-8), and one diaryl heptanoid, giffonin I (9), were isolated from the methanol extract of the leaves of Corylus avellana. Its hazelnut is the PGI product of the Campania region (Italy) known as "Nocciola di Giffoni". The MeOH extract of C. avellana leaves and giffonins A-I (1-9) were evaluated for their inhibitory effects on human plasma lipid peroxidation induced by H2O2 and H2O2/Fe(2+), by measuring the concentration of TBARS (thiobarbituric acid reactive su… Show more

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Cited by 37 publications
(65 citation statements)
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“…Moreover, compounds 1e9 were identified by analysis of spectroscopic data in comparison to those reported in literature as (Matlawska et al, 1994) (Kirmizibekmez et al, 2014), quercetin 3-O-a-L-rhamnopyranoside (4) (Materska et al, 2003), giffonin I (5) (Masullo et al, 2015b), kaempferol 3-O-a-Lrhamnopyranoside (6) (Ahmed et al, 1989), kaempferol 3-O-(4 00 -cis-p-coumaroyl)-a-L-rhamnopyranoside (7) (Yang et al, 2013), kaempferol 3-O-(4 00 -trans-p-coumaroyl)-a-L-rhamnopyranoside (8) (Yang et al, 2013), and alnusone (9) (Masullo et al, 2015b).…”
Section: Resultsmentioning
confidence: 99%
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“…Moreover, compounds 1e9 were identified by analysis of spectroscopic data in comparison to those reported in literature as (Matlawska et al, 1994) (Kirmizibekmez et al, 2014), quercetin 3-O-a-L-rhamnopyranoside (4) (Materska et al, 2003), giffonin I (5) (Masullo et al, 2015b), kaempferol 3-O-a-Lrhamnopyranoside (6) (Ahmed et al, 1989), kaempferol 3-O-(4 00 -cis-p-coumaroyl)-a-L-rhamnopyranoside (7) (Yang et al, 2013), kaempferol 3-O-(4 00 -trans-p-coumaroyl)-a-L-rhamnopyranoside (8) (Yang et al, 2013), and alnusone (9) (Masullo et al, 2015b).…”
Section: Resultsmentioning
confidence: 99%
“…Moreover, the 1 H NMR spectrum displayed signals due to a disubstituted trans-olefinic group at d 6.59 (m, H-9) and 5.82 (d, J ¼ 16.1 Hz, H-10), and four methylene groups at d 3.05 (2H, br t, J ¼ 6.5 Hz), 2.73 (2H, br t, J ¼ 6.5 Hz), 2.69 (2H, m), 2.37 and 2.35 (each 1H, m). The 13 C NMR spectrum of 10 showed 19 carbon signals, typical of diaryl ether heptanoid derivatives (Masullo et al, 2015b), comprising a signal at d 203.9, ascribable to a carbonyl group (Table 1). The signal at d 5.76 was attributed to H-6, which generally resonates at an abnormally high field, due to the anisotropic effect of the A ring in diaryl ether heptanoids (Masullo et al, 2015a(Masullo et al, , 2015b.…”
Section: Resultsmentioning
confidence: 99%
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