Gill surface interaction model for trace-metal toxicity to fishes:  role of complexation, pH, and water hardness

Pagenkopf, Gordon K.

doi:10.1021/es00112a007

Cited by 488 publications

(305 citation statements)

References 21 publications

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“…Biotic ligand models (BLM) were developed to incorporate local bioavailability in risk assessment procedures. The conceptual framework for the BLM is an adaptation of the gill surface interaction model, originally proposed by Pagenkopf [78,79] and more recently utilized by many others (e.g., [80][81][82][83][84]), and the free ion activity model of toxicity, extensively reviewed by e.g., [85,86]. The general framework is illustrated in Figure 4.…”

Section: Risks Assessment In Aquatic Environmentsmentioning

confidence: 99%

“…The general framework is illustrated in Figure 4. The model is based on the hypothesis that toxicity (expressed as No-effect concentration; NOEC) is not simply related to total aqueous TM concentration but that both TM-ligand complexation and TM interaction with competing cations at the site of action of toxicity need to be considered [78,87,88]. Mortality occurs when the concentration of TM bound to the biotic ligand exceeds a threshold concentration.…”

Section: Risks Assessment In Aquatic Environmentsmentioning

confidence: 99%

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Fate of Trace Metals in Anaerobic Digestion

Fermoso

Hullebusch²,

Guibaud

et al. 2015

Advances in Biochemical Engineering/Biotechnology

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A challenging, and largely uncharted, area of research in the field of anaerobic digestion science and technology is in understanding the roles of trace metals in enabling biogas production. This is a major knowledge gap and a multifaceted problem involving metal chemistry; physical interactions of metal and solids; microbiology; and technology optimization. Moreover, the fate of trace metals, and the chemical speciation and transport of trace metals in environmentsoften agricultural lands receiving discharge waters from anaerobic digestion processes -is completely unknown but simultaneously represents challenges for environmental protection and opportunities to close process loops in anaerobic biotechnologies. Affiliation 1.

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Section: Risks Assessment In Aquatic Environmentsmentioning

confidence: 99%

Section: Risks Assessment In Aquatic Environmentsmentioning

confidence: 99%

Fate of Trace Metals in Anaerobic Digestion

Fermoso

Hullebusch²,

Guibaud

et al. 2015

Advances in Biochemical Engineering/Biotechnology

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“…Interestingly, there was a positive and significant correlation (Pearson correlation coefficient 0.81, p ¼ 0.015) between water hardness and the concentration of inherent DOC in the natural waters used in the present study. The bioavailability of Cu is known to be influ enced by a number of water chemistry parameters, including the concentrations of major cations (Ca, Mg, Na) [14,15]. Water hardness has been shown to decrease Cu sensitivity of glochidia in exposures using reconstituted waters.…”

Section: Effect Of Inherent Doc On Copper Toxicitymentioning

confidence: 99%

“…Major ions, including Ca, Mg, and Na, compete with metal ions at the site of uptake [14,15]. Similarly, the presence of ligands, such as dissolved organic carbon (DOC), can bind with the metal ion and reduce its bioavailability [16].…”

Section: Introductionmentioning

confidence: 99%

The effect of natural dissolved organic carbon on the acute toxicity of copper to larval freshwater mussels (glochidia)

Gillis

McGeer

Mackie

et al. 2010

Enviro Toxic and Chemistry

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The present study examined the effect of dissolved organic carbon (DOC), both added and inherent, on Cu toxicity in glochidia, the larvae of freshwater mussels. Using incremental additions of natural DOC concentrate and reconstituted water, a series of acute copper toxicity tests were conducted. An increase in DOC from 0.7 to 4.4 mg C/L resulted in a fourfold increase (36 150 mg Cu/L) in the 24 h median effective concentration (EC50) and a significant linear relationship (r 2 0.98, p 0.0008) between the DOC concentration and the Cu EC50 of Lampsilis siliquoidea glochidia. The ameliorating effect of added DOC on Cu toxicity was confirmed using a second mussel species, the endangered (in Canada) Lampsilis fasciola. The effect of inherent (i.e., not added) DOC on Cu toxicity was also assessed in eight natural waters (DOC 5 15 mg C/L). These experiments revealed a significant relationship between the EC50 and the concentration of inherent DOC (r 2 0.79, p 0.0031) with EC50s ranging from 27 to 111 mg Cu/L. These laboratory tests have demonstrated that DOC provides glochidia with significant protection from acute Cu toxicity. The potential risk that Cu poses to mussel populations was assessed by comparing Cu and DOC concentrations from significant mussel habitats in Ontario to the EC50s. Although overall mean Cu concentration in the mussel's habitat was well below the acutely toxic level given the concentration of DOC, episodic Cu releases in low DOC waters may be a concern for the recovery of endangered freshwater mussels. The results are examined in the context of current Cu water quality regulations including the U.S. Environmental Protection Agency's (U.S. EPA) biotic ligand model.

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“…In fact, 52 out of 59 cases conformed to the assumption [16] and validated the applicability of FIAM. Recently, the Gill Surface Interaction Model (GSIM) [17] has been combined with FIAM concepts to form the Biotic Ligand Model (BLM). This model envisages that toxicity is due to accumulation of metal at physiologically active sites such as the gill in fish.The BLM approach has already received wide acceptance and has been incorporated in the regulatory framework for copper by the US Environmental Protection Agency (EPA).…”

Section: Introductionmentioning

confidence: 99%

Assessing toxicity of mining effluents: equilibrium- and kinetics-based metal speciation and algal bioassay

2008

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Environmental context. The release of mining effluents exposes natural waters to excess metals and thereby threatens both human and environmental health. The present study explores the toxicity of aqueous mining effluents collected from a mining area in Sudbury (Ontario, Canada), using two different methods for determination of metal speciation, and an algal toxicity study. The results show reasonable correlation between metal speciation and the observed toxicity and suggest the importance of taking into account other factors related to water quality criteria such as nutrient concentrations, diluent water and presence of other toxic metals that can greatly influence the toxicological result.Abstract. The present study explores the toxicity of aqueous mining and municipal effluents from the Sudbury area (Canada) using equilibrium-and kinetics-based estimates of metal speciation and chronic toxicity studies using algae (Pseudokirchneriella subcapitata). Free metal ion concentration was determined by the Ion Exchange Technique (IET) and a computer speciation code, Windermere Humic Aqueous Model (WHAM ) VI. Labile metal concentration was determined using the Competing Ligand Exchange Method. In general, no correlation was found between the observed IC 25 (concentration of test substance that inhibits growth of organism by 25%) and the [Ni] labile , [Ni 2+ ] IET or [Ni 2+ ] WHAM , probably because of contributions by other metals such as Cu and Zn being also significant. Reasonable correlation (r 2 = 0.7575) was found when the observed toxicity was compared with the sum of free metal ions of Cu, Ni, and Zn predicted by WHAM. The results of the present study reveal the importance of taking into account other factors related to water quality criteria such as nutrient concentrations, diluent water, and the presence of other toxic metals, which greatly influence the toxicological result in complex, multi-metal contaminated waters.

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Gill surface interaction model for trace-metal toxicity to fishes: role of complexation, pH, and water hardness

Cited by 488 publications

References 21 publications

Fate of Trace Metals in Anaerobic Digestion

Fate of Trace Metals in Anaerobic Digestion

The effect of natural dissolved organic carbon on the acute toxicity of copper to larval freshwater mussels (glochidia)

Assessing toxicity of mining effluents: equilibrium- and kinetics-based metal speciation and algal bioassay

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