GIMAP Proteins in T-Lymphocytes

Abstract

(GIMAPs) GTPase of the immunity associated protein family are a novel protein family of putative small GTPases. GIMAPs are mainly expressed in the cells of the immune system and have been associated with immunological functions, such as thymocyte development, apoptosis of peripheral lymphocytes and T helper cell differentiation. GIMAPs have also been linked to immunological diseases, such as T cell lymphopenia, leukemia and autoimmune diseases. In this review we examine the role of GIMAP proteins in T-lymphocyte biology.

Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia

“…Altogether, WGS identified a total of 751 novel structural abnormalities in the 4 index T-PLL genomes. In addition to a focused 9.1-Mb rearrangement in 1 of 4 index genomes consistent with loss of genetic material comprising the ATM locus as anticipated by earlier studies, 20 this analysis also highlighted a novel disruption on chromosome 14q24 in 1 of 4 genomes affecting the NUMB gene, which links Notch pathways with T-cell receptor signaling in T lymphocytes, 21 and loss of 1.0 to 2.0 Mb of genetic material on chromosome 7q36 in 2 of 4 genomes comprising the histone methyltransferase EZH2 gene and genes in the GIMAP family known to influence T-lymphocyte development and function 22 (supplemental …”

NOTCH1–RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

“…Exceptions to this general rule were observed, however. The most notable of these is found in the GTPase of the immunity-associated protein family (GIMAP family) gene cluster, which lies within a CTCF domain on chromosome 7q36 and encodes a family of GTPases implicated in regulation of lymphocyte development, survival, and homeostasis (28). Three dynamic NOTCH1-RBPJ sites lie within this cluster, and five flanking GIMAP genes (GIMAP2, GIMAP1, GIMAP5, GIMAP6, and GIMAP7) score as NOTCH1 target genes (Fig.…”

Transcriptomic and proteomic analyses of splenic immune mechanisms of rainbow trout (Oncorhynchus mykiss) infected by Aeromonas salmonicida subsp. salmonicida

“…GTPase of the immunity associated protein family (GIMAPs) is a novel protein family of putative small GTPases. GIMAPs are mainly expressed in the cells of the immune system and have been associated with immunological functions, such as thymocyte development, apoptosis of peripheral lymphocytes, and T helper cell differentiation [60]. The family may also provide clues to yet unknown self-defense mechanisms common in higher organisms [61].…”

“…GIMAP7 is considered an important gene for anti-apoptotic T cell pathway and T helper (TH) cell differentiation. This gene is located in the endoplasmic reticulum and Golgi, with expression in the spleen, thymus, lymph nodes, and PBL [60,61]. Upregulation of GIMAP7 was presented in the distal intestine of Atlantic salmon (S. salar L.) during the development of soybean meal-induced enteritis [62].…”