Ginger, a Possible Candidate for the Treatment of Dementias?

Schepici, Giovanni; Contestabile, Valentina; Valeri, Andrea; Mazzon, Emanuela

doi:10.3390/molecules26185700

Cited by 15 publications

(9 citation statements)

References 84 publications

(106 reference statements)

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“…Researchers assessed acetylcholinesterase (AChE) as the most promising molecular target for ginger compounds with multiple molecular targets in Alzheimer's disease (Azam, et al, 2014;Wheeler, 2003). Additionally, ginger compounds inhibit the activity of butyrylcholinesterase (BChE) by binding to Trp82 and Tyr332 residues (Cuya and França, 2020;Cuya et al, 2018;Schepici, et al, 2021). A reduction in clinical symptoms of mice with Experimental autoimmune encephalomyelitis (EAE) as well as a reduction of expression of IL-27 and IL-33 in their spinal cords is also observed (Jafarzadeh et al, 2014).…”

Section: Neurodegenerative Agentmentioning

confidence: 99%

Ginger–a potential source of therapeutic and pharmaceutical compounds

Verma¹,

Bisen²

2022

Journal of Food Bioactives

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Ginger is traditionally known for its therapeutic and pharmaceutical properties. It has been used widely to treat various health problems such as high blood pressure, coughs, colds, swelling, nausea, rheumatic disorders, vomiting, bronchitis, indigestion, gastric ulcers, and behavioral problems. Shogaol and Gingerol are anti-inflammatory, anti-fever, anti-pain, and anti-cough compounds that may help treat a cold. This review provides an up-to-date understanding of the impact of ginger and its active compounds on human health. Various ginger compounds such as gingerol, shogaols, zingiberene, zingerone, paradols and zingerone are receiving attention for their clinical applications and pharmaceutical properties. Studies indicate that ginger is anti-inflammatory, anti-tumor, antimicrobial, antiemetic, hepatoprotective, and neuroprotective. During the inflammatory response, ginger inhibits (NF-κB) and immune system activation in addition to many other cellular processes. Ginger has shown benefits in preclinical and clinical studies for neurology, cardiovascular disease, and cancer. These findings indicate the necessity for further in vivo and clinical studies.

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Section: Neurodegenerative Agentmentioning

confidence: 99%

Ginger–a potential source of therapeutic and pharmaceutical compounds

Verma¹,

Bisen²

2022

Journal of Food Bioactives

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“…Ginger consists of more than 400 different substances, including lipids, carbohydrates, terpenes, and phenolic compounds . Shogaols, gingerols, zingerone, gingerdione, capsaicin, paradols, and zerumbone belong to its pungent constituents, while cumene, camphene, borneol, and zingiberol belong to the aromatic group . Among them, shogaol, gingerol, and paradols are the most abundant phenolic compounds of ginger extracts; other phenolic compounds are quercetin, gingerenone-A, and 6-dehydrogingerdione.…”

Section: Introductionmentioning

confidence: 99%

“…Among them, shogaol, gingerol, and paradols are the most abundant phenolic compounds of ginger extracts; other phenolic compounds are quercetin, gingerenone-A, and 6-dehydrogingerdione. 6-Gingerol and 6-shogaol are considered as the main pharmacologically active components of ginger, regarding their antioxidant and anti-inflammatory properties. , Gingerol can be easily transformed into shogaol at high temperatures, and this process is affected by the form of ginger (fresh or dried) and the type of heat (wet or dry) . After hydrogenation, shogaols can be converted to paradols.…”

Section: Introductionmentioning

confidence: 99%

“…After hydrogenation, shogaols can be converted to paradols. Zingerone [4-(4-hydroxy-3-methoxyphenyl)-butan-2-one] can be obtained from drying or cooking of the rhizome, being also chemically related to eugenol and vanillin . The major terpene components are α-curcumene, α-farnesene, β-bisabolene, zingiberene, and β-sesquiphellandrene, which constitute the main components of ginger essential oils (Figure ).…”

Section: Introductionmentioning

confidence: 99%

“…Although some previous articles address the general role of ginger in human disorders and neurodegenerative diseases, ,, focused literature reviews on the effects of ginger in PD are lacking. Herein, we discuss recent findings on the beneficial role of ginger in PD, focusing on potential underlying molecular mechanisms.…”

Section: Introductionmentioning

confidence: 99%

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Elucidating the Beneficial Effects of Ginger (Zingiber officinale Roscoe) in Parkinson’s Disease

Angelopoulou

Paudel

Papageorgiou

et al. 2022

ACS Pharmacol. Transl. Sci.

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Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease (AD), and its pathogenesis remains obscure. Current treatment approaches mainly including levodopa and dopamine agonists provide symptomatic relief but fail to halt disease progression, and they are often accompanied by severe side effects. In this context, natural phytochemicals have received increasing attention as promising preventive or therapeutic candidates for PD, given their multitarget pharmaceutical mechanisms of actions and good safety profile. Ginger (Zingiber officinale Roscoe, Zingiberaceae) is a very popular spice used as a medicinal herb throughout the world since the ancient years, for a wide range of conditions, including nausea, diabetes, dyslipidemia, and cancer. Emerging in vivo and in vitro evidence supports the neuroprotective effects of ginger and its main pharmaceutically active compounds (zingerone, 6-shogaol, and 6-gingerol) in PD, mainly via the regulation of neuroinflammation, oxidative stress, intestinal permeability, dopamine synaptic transmission, and possibly mitochondrial dysfunction. The regulation of several transcription factors and signaling pathways, including nuclear factor kappa B (NF-κB), p38 mitogen-activated protein kinase (MAPK), phosphatidylinositol-3-kinase (PI3K)/Ak strain transforming (Akt), extracellular signal-regulated kinase (ERK) 1/2, and AMP-activated protein kinase (AMPK)/proliferator-activated receptor gamma coactivator 1 alpha (PGC1α) have been shown to contribute to the protective effects of ginger. Herein, we discuss recent findings on the beneficial role of ginger in PD as a preventive agent or potential supplement to current treatment strategies, focusing on potential underlying molecular mechanisms.

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Ameliorative Effects of Ginger on Allergic Diseases: An Updated Review

Khaki Vaighan,

Shams,

Tatari

et al. 2024

Molecular Nutrition Food Res

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The hypersensitivity reaction of the immune system to harmless environmental substances causes allergic diseases. Today, about 22%–30% of the world's population suffers from allergic diseases. Since the probability of change in the genetic structure during the past decades of lives is very low, genetic disorders cannot be blamed for causing allergic diseases. Thus, factors such as air pollution, climate change, change in diet, increased antibiotics consumption, change in the gut microbiome, migration toward urban areas, and increase in airborne allergens should be considered as the main causes of the spread and increase in allergic diseases. Methods of preventing contact with allergens, drug treatment, and allergen‐specific immunotherapy are used to treat allergic diseases. In recent years, the therapeutic efficacy of herbal compounds has been significantly investigated by the scientific community, because these compounds have very few side effects. Ginger is one of the plant compounds that have anti‐inflammatory, antioxidant, and immunomodulatory properties. The ameliorative effects of this plant on allergic diseases have been identified. Therefore, the aim of this short review is to summarize the knowledge, which is available about the ameliorative properties of the compounds found in the ginger plant that can reduce the clinical symptoms of allergic diseases.The hypersensitivity reaction of the immune system to harmless environmental substances causes allergic diseases. Today, about 22%–30% of the world's population suffers from allergic diseases. Since the probability of change in the genetic structure during the past decades of lives is very low, genetic disorders cannot be blamed for causing allergic diseases. Thus, factors such as air pollution, climate change, change in diet, increase in antibiotic consumption, change in the gut microbiome, migration toward urban areas, and increase in airborne allergens should be considered as the main causes of the spread and increase in allergic diseases. Methods of preventing contact with allergens, drug treatment, and allergen‐specific immunotherapy are used to treat allergic diseases. In recent years, the therapeutic efficacy of herbal compounds has been significantly investigated by the scientific community, because these compounds have very few side effects. Ginger is one of the plant compounds that have antiinflammatory, antioxidant, and immunomodulatory properties. The ameliorative effects of this plant on allergic diseases have been identified. Therefore, the aim of this short review is to summarize the knowledge, which is available about the ameliorative properties of the compounds found in the ginger plant that can reduce the clinical symptoms of allergic diseases.

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Ginger, a Possible Candidate for the Treatment of Dementias?

Cited by 15 publications

References 84 publications

Ginger–a potential source of therapeutic and pharmaceutical compounds

Ginger–a potential source of therapeutic and pharmaceutical compounds

Elucidating the Beneficial Effects of Ginger (Zingiber officinale Roscoe) in Parkinson’s Disease

Ameliorative Effects of Ginger on Allergic Diseases: An Updated Review

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