Ginger and Its Bioactive Component Inhibit Enterotoxigenic Escherichia coli Heat-Labile Enterotoxin-Induced Diarrhea in Mice

Abstract

Ginger is one of the most commonly used fresh herbs and spices. Enterotoxigenic Escherichia coli heatlabile enterotoxin (LT)-induced diarrhea is the leading cause of infant death in developing countries. In this study, we demonstrated that ginger significantly blocked the binding of LT to cell-surface receptor G M1 , resulting in the inhibition of fluid accumulation in the closed ileal loops of mice. Biological-activityguided searching for active components showed that zingerone (vanillylacetone) was the likely active constituent responsible for the antidiarrheal efficacy of ginger. Further analysis of chemically synthesized zingerone derivatives revealed that compound 31 (2-[(4-methoxybenzyl)oxy]benzoic acid) significantly suppressed LT-induced diarrhea in mice via an excellent surface complementarity with the B subunits of LT. In conclusion, our findings provide evidence that ginger and its derivatives may be effective herbal supplements for the clinical treatment of enterotoxigenic Escherichia coli diarrhea.

Effects of Ginger and Its Constituents on Airway Smooth Muscle Relaxation and Calcium Regulation

“…Here, ginger was not among the phytotherapeutics discussed, although it has been implicated in alleviating other ailments and diseases, including nausea and emesis in pregnancy, hypertension, cancer, dyspepsia, and diarrhea (12,13,(28)(29)(30). Only three studies have examined the physiologic effects of ginger on the airway, and in all of these studies, a crude ginger extract was used.…”

The Effect of Zingiber officinale Roscoe (Ginger) on Dentin Microhardness: An in vitro Study

“…Together with its anti-inflammatory, antimicrobial, antioxidant and analgesic properties, this natural product has the potential to be utilized and formulated to become a very effective irrigant for root canal treatment. Other favorable aspects of this plant as an alternative root canal irrigating solution are its negligible toxicity values and has a benign adverse reaction profile with an oral median lethal dose of 5 g/kg (Chen et al, 2007). The plant is safe when ingested as proven by other studies which uses Z. officinale Roscoe extract to treat several systemic diseases such as arthritis and gastrointestinal discomfort (Ali et al, 2008).…”

Antiadhesive Effect of Plant Compounds in Bacteria

“…In some studies, modern technology search for non-conventional antimicrobials is based on folk medicine (Birdi et al, 2010;Brijesh et al, 2009;Chen et al, 2007aChen et al, , 2007bChen et al, , 2009Coutiño et al, 2001;Kavitha & Niranjali 2009;). In recent years, the increase in number of articles including new trends in VFs research, like biofilm inhibition or quorum sensing-disrupting is noticeable.…”