Gingival enlargement due to Cyclosporine A therapy in aplastic anaemia

Sabnis, Girish; Karnik, Niteen D; Sundar, Uma; Adwani, Sikandar

doi:10.4103/0253-7613.84988

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…There are no statistics on the prevalence or risk factors for oral symptoms in AA patients. Submucosal hemorrhages, gingival swellings, herpetic lesions, spontaneous gingival bleeding, pallor, and periodontitis have all been documented in earlier case reports (12,13). Rapidly progressing severe periodontitis is associated with cyclic neutropenia, agranulocytosis, and leukocyte adhesion deficiency, among other quantitative and qualitative neutrophil defects (14).…”

Section: Discussionmentioning

confidence: 88%

Oral Manifestations of Aplastic Anemia: A Case Report

Hedayati Panah,

Shahsavand Baghdadi,

Fatholahi

2023

Avicenna J Dent Res

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Aplastic anemia (AA) is a rare disease characterized by pancytopenia, susceptibility to infection, and difficulty maintaining hemostasis. Drugs are considered to be one of the most important risk factors associated with AA. Various studies have identified the pharmaceutical agents that may contribute to the development of AA. It is common for patients with severe periodontal disease and AA to experience spontaneous bleeding during brushing in terms of thrombocytopenia, which may further exacerbate dental problems. AA patients require comprehensive periodontal treatment that necessitates collaboration with a hematologist.

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Section: Discussionmentioning

confidence: 88%

Oral Manifestations of Aplastic Anemia: A Case Report

Hedayati Panah,

Shahsavand Baghdadi,

Fatholahi

2023

Avicenna J Dent Res

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“…Reported cases of gingival enlargements were induced by different drugs; CCBs (50/119 – of which amlodipine-25;[8910111213141516171819202122232425262728] nifedipine-13;[26293031323334353637383940] verapamil-4;[41] felodipine-2;[4243] nisoldipine-1;[44] manidipine-1;[45] and unspecified CCBs-4[46]); phenytoin (11/119);[4748495051525354555657] cyclosporine (31/119);[3546585960616263646566676869707172737475] phenobarbital (4/119);[767778] sodium valproate (3/119 - including one report of congenital drug-induced gingival hyperplasia);[798081] d-penicillamine (2/119);[82] combination oral contraceptive pill-lynestrenol and ethinyl estradiol (1/119);[83] vigabatrin (1/119). [84] Cases of gingival enlargement after combination drug therapy have also been reported; a combination of cyclosporine and CCBs (11/119);[354685...…”

Section: Resultsmentioning

confidence: 99%

“…[35606164656667686970727475] It has also been used for treating aplastic anemia,[586073] psoriasis,[62] and Behcet disease. [71] Cyclosporine is known to alter the metabolism of gingival fibroblasts and also upregulates specific growth factors such as platelet-derived growth factor B, thereby causing adverse gingival changes such as overgrowth.…”

Section: Discussionmentioning

confidence: 99%

Drug-induced gingival overgrowth: A critical insight into case reports from over two decades

Samudrala

Chava

Chandana

et al. 2016

J Indian Soc Periodontol

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Drug-induced gingival overgrowth (DIGO) is a well-recognized adverse effect of certain systemic medications. Calcium channel blockers, anticonvulsants, and immunosuppressants are frequently implicated drugs in the etiology of DIGO. Drug variables, plaque-induced inflammation, and genetic factors are the three important factors in the expression of gingival changes after systemic medication use. Careful clinical examination and thorough history taking form the basis for diagnosis of DIGO. Histopathological examination is often neglected; however, it is an important aid that helps in differential diagnosis. Cessation or change of drug and meticulous plaque control often leads to regression of the lesion, which however might need surgical correction for optimal maintenance of gingival health. The purpose of the present article is to review case reports and case series published in the last two decades and to assimilate and compile the information for clinical applications such as diagnosis and therapeutic management of DIGO.

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Gingival enlargement due to Cyclosporine A therapy in aplastic anaemia

Cited by 2 publications

References 5 publications

Oral Manifestations of Aplastic Anemia: A Case Report

Oral Manifestations of Aplastic Anemia: A Case Report

Drug-induced gingival overgrowth: A critical insight into case reports from over two decades

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