Gingival juvenile xanthogranuloma in an adult patient: case report with immunohistochemical analysis and literature review

Consolaro, Alberto; Sant’Ana, Eduardo; Lawall, Melaine A.; Consolaro, Maria Fernanda M-O.; Bacchi, Carlos E.

doi:10.1016/j.tripleo.2008.09.032

Cited by 21 publications

(30 citation statements)

References 43 publications

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“…The patient in this case had no history of cancer, and the histopathologic examination ruled out metastatic carcinoma. Xanthogranulomas are a nonLangerhans cell histiocytosis, which was first described by Adamson in 1905 [1]. While it is a benign and often self-healing disorder that usually affects infants and children, oral lesions in adults can occur [1].…”

Section: Differential Diagnosismentioning

confidence: 99%

“…Xanthogranulomas are a non-Langerhans cell histiocytotic lesion most commonly seen on the skin of infants and children.1 Lesions in adults can occur; and, rarely, xanthogranulomas present in the oral cavity [1,2]. While the etiology is unknown, this entity is thought to be reactive [2].…”

Section: Introductionmentioning

confidence: 99%

“…The lesions also have a variable number of Touton giant cells and principally perivascular and perilesional inflammatory cells [3,4]. Immuno histochemically, the lesion is positive for CD68, factor XIIIa, fascin, and alpha-antitrypsin and negative for S-100, CD1a, beta-actin, and desmin [1]. Most cases of cutaneous xanthogranuloma do not require treatment and have a favorable prognosis because the lesions spontaneously regress [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Immuno histochemically, the lesion is positive for CD68, factor XIIIa, fascin, and alpha-antitrypsin and negative for S-100, CD1a, beta-actin, and desmin [1]. Most cases of cutaneous xanthogranuloma do not require treatment and have a favorable prognosis because the lesions spontaneously regress [1][2][3][4][5]. However, spontaneous regression has only been reported in the case of one oral lesion [2].…”

Section: Introductionmentioning

confidence: 99%

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A Nonhealing Periapical Radiolucency

Vargo

Bilodeau

Jaradat

et al. 2016

JDHODT

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Background: This case discusses a radiolucent lesion in the anterior mandible, which initially was thought to be due to endodontic failure. However, the final diagnosis was xanthogranuloma. Case description:We have reported a case of xanthogranuloma in the mandible found at the apices of two endodontically treated teeth. When present in the oral cavity, it can appear similar to several more common entities. While the radiolucent periapical lesion was thought to be the result of non-healing root canal therapy, the excisional biopsy yielded the diagnosis of xanthogranuloma. Removal of the lesion has resulted in excellent healing, as the surgeon expected. Practical implications:This case demonstrates the importance of biopsy in definitive diagnosis of oral lesions and lesions found at the apices of previously endodontically treated teeth.

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Section: Differential Diagnosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Nonhealing Periapical Radiolucency

Vargo

Bilodeau

Jaradat

et al. 2016

JDHODT

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“…Oncocytic cell type of JXG reveals many cells with a rather pronounced, homogenous, slightly granular cytoplasm, and fairly well-demarcated cell borders, with huge multinucleated cells with ground glass appearance of the cytoplasm [52]. JXG can be differentiated from Langerhans cell histiocytosis by electron microscopy, which contains Birbeck's granules that have a pentalaminar, rodlike, tubular structures with characteristic periodicity and occasional dilated terminal ends [53].…”

Section: Juvenile Xanthogranuloma (Jxg)mentioning

confidence: 99%

Granules in Granular Cell Lesions of the Head and Neck: A Review

Yogesh

Sowmya

2011

ISRN Pathology

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Granular cell lesions of the oral mucosa, jaws, and salivary glands constitute a heterogeneous group of lesions which may be either odontogenic, salivary gland, or metastatic in origin. Granular cells in these proliferations most commonly are the result of lysosomal accumulation, aging, degenerative, metabolic alteration, increased apoptosis, cytoplasmic autophagocytosis, and many more. Many benign and malignant tumors that occur in the oral cavity contain granular cells as a characteristic component of their pathology. Sometimes dilemma exists in the proper diagnosis of these granular cell lesions and the cell of origin because they share similar light and electron microscopic features. Therefore, immunohistochemistry helps to confirm histologic impressions and differentiate other neoplastic entities with granular cytoplasmic features. Granularity in a normal histopathology is a rare but innocuous change and does not influence the biologic behaviour of smooth muscle tumors except few lesions such as cutaneous granular cell angiosarcoma and granular cell ameloblastoma which have shown poor prognosis. This paper aims to review the clinical and pathologic features, different immunohistochemical profiles of granules in granular cell lesions of head and neck with an attempted working classification.

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