Gingival overgrowth induced by cyclosporin A in rats

Kitamura, Kanji; Morisaki, Ichijiro; Kato, Kazuko; Mihara, J; Sobue, S; Hamada, Shigeyuki

doi:10.1016/0003-9969(90)90213-t

Cited by 34 publications

(23 citation statements)

References 7 publications

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“…In Majola et al [56] study, no linear relationship was perceived between the side-effects of phenytoin and length of drug consumption, but the lesions were more prevalent in younger patients. Although animal studies have confirmed such results, no specific in vitro study has been conducted on this issue yet, and the reduced synthesis of protein and collagen by fibroblasts in the phenytoin-or cyclosporine-induced gingival overgrowth has not shown to be correlated with age [57] [58].…”

Section: +mentioning

confidence: 99%

Phenytoin Effects on Proliferation and Induction of IL1<i>β</i> and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Vahabi¹,

Moslemi²,

Nazemisalman³

et al. 2014

OJST

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Background: Gingival Overgrowth (GO) is a well documented and unwanted side effect that occurs mainly as a result of certain antiseizure, phenytoin. The aim of this study was to compare the effect of phenytoin on proliferation and production of IL1β and PGE2 in cultured human gingival fibroblasts (HGF) of children and adults. Materials and Methods: Normal HGFs were obtained from 4 healthy children and 4 adult and then were cultured with phenytoin (20 mg/ml). MTT test was used to evaluate the proliferation and ELISA to determine the level of IL1β and PGE2 production by HGFs. Analysis of proliferation were assessed by Independent T-Test and ANOVA analysis was used to assess the level of IL1β and PGE2 production with an a error level less than 0.05. Results: The proliferation of HGF was not affected significantly by phenytoin in both cultured fibroblast sources (P > 0.05). Phenytoin induced a significantly higher formation of IL1β and PGE2 in child's HGFs as compared to adult's HGFs (P < 0.05). Conclusion: The results suggest that different inflammatory responses and cytokine formation by child's and adult's HGFs are the probable key elements that cause different reactions of phenytoin therapy. More advanced and systematic studies are needed to verify these findings.

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Section: +mentioning

confidence: 99%

Phenytoin Effects on Proliferation and Induction of IL1<i>β</i> and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Vahabi¹,

Moslemi²,

Nazemisalman³

et al. 2014

OJST

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“…

C yclosporin A (CSA)-induced gingival alterations have been observed in clinical cases and in animal models. [1][2][3][4][5][6][7][8][9] Effects of CSA on gingival fibroblasts have been investigated and CSA has been suggested to play a significant role in gingival hyperplasia. [10][11][12][13] The significance of CSA on alveolar bone has received limited attention, although recent studies have focused on the effect of CSA on bone.

…”

mentioning

confidence: 99%

Effects of Cyclosporin A on Alveolar Bone: An Experimental Study in the Rat

Hsieh²,

Nieh

et al. 1999

Journal of Periodontology

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KyushuDental Society AdtiScaftbl 45 (4) :425-445, 1991. fi SSE Vc St # 6 !llva7EEi･ttimaes o ,Eif ng fi Ek ei ma-g-6 =,ge asM1fi-t < eitwtwNaR(k-pt n 1>-JLNiltsptJk7,JNvadvgiiP\suU (lee : ]k")iZ\ijR) SPnt 3 lf 6 fi 25 eXff Combined Debility Kimura) Three-week-old male rats of Wi$tar strain were given calcium-deficient food for 3 weeks and experimental bone debility was induced in them. Food was then changed to normal standard food and the effect on the debilitated alveolar bones of the treatment combined with la-OH-Dg (O,1 "g/kg, oral administration), an analogue of active vitarnin D3, and eel calcitonin (O.2 U/kg, intramuscular injection) was investigated. The results were as follows : 1. Radiological findings In the calcium-deficient food + standard food + active type vitamin D3 + ECT group and calcium-deficient food + standard food + ECT + active type vitamin D3 group as compared with the group given only normal standard food, the alveolar bones showed thicker bone layers and increase in and regular arrangement of trabeculae. Calcium-deficient food + standard food + ECT + active type vitamin D3 group showed the most increase in trabeculae next to the control group and about even density. 2. Findings from the analysis on the X-ray microanalyzer In relative Ca ratio and P ratio as compared with the control group, calcium-deficient food + standard food + ECT + active type vitamin D3 group showed most approximation, 3. Histopathological findings 1) Findings form contact rnicroradiograms In the group treated by cornbination with ECT and active type vitamin D3, the alveolar bones grew thick; Haversian canals and the surrounding bone lacunae increased; and acceleration effect on the bone construction was recongnized.

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“…In this study, we examined the preventive effect of Tan IIA on cyclosporine A gingival overgrowth in a rat model. Based on previous findings that macroscopic gingival overgrowth in rats is more conspicuous in the buccal than in lingual gingiva and less severe in the maxilla than in the mandible , we focused on the impacts of cyclosporine A treatment or cyclosporine A + Tan IIA treatment on the buccal gingiva by evaluating the buccolingual sections of the mandibular first molars and their surrounding periodontal tissues in rats.…”

Section: Discussionmentioning

confidence: 99%

Tanshinone IIA treatment alleviated the rat gingival connective tissue overgrowth induced by cyclosporine A

Liu

et al. 2015

J of Periodontal Research

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Gingival overgrowth induced by cyclosporin A in rats

Cited by 34 publications

References 7 publications

Phenytoin Effects on Proliferation and Induction of IL1<i>β</i> and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Phenytoin Effects on Proliferation and Induction of IL1<i>β</i> and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Effects of Cyclosporin A on Alveolar Bone: An Experimental Study in the Rat

Tanshinone IIA treatment alleviated the rat gingival connective tissue overgrowth induced by cyclosporine A

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Gingival overgrowth induced by cyclosporin A in rats

Cited by 34 publications

References 7 publications

Phenytoin Effects on Proliferation and Induction of IL1&lt;i&gt;β&lt;/i&gt; and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Phenytoin Effects on Proliferation and Induction of IL1&lt;i&gt;β&lt;/i&gt; and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Effects of Cyclosporin A on Alveolar Bone: An Experimental Study in the Rat

Tanshinone IIA treatment alleviated the rat gingival connective tissue overgrowth induced by cyclosporine A

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Phenytoin Effects on Proliferation and Induction of IL1<i>β</i> and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

Phenytoin Effects on Proliferation and Induction of IL1<i>β</i> and PGE2 in Pediatric and Adults’ Gingival Fibroblasts