2023
DOI: 10.3390/cimb45120604
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Ginkgo biloba: Antioxidant Activity and In Silico Central Nervous System Potential

Eduardo Suárez-González,
Jesús Sandoval-Ramírez,
Jorge Flores-Hernández
et al.

Abstract: Ginkgo biloba (GB) extracts have been used in clinical studies as an alternative therapy for Alzheimer’s disease (AD), but the exact bioaction mechanism has not yet been elucidated. In this work, an in silico study on GB metabolites was carried out using SwissTargetPrediction to determine the proteins associated with AD. The resulting proteins, AChE, MAO-A, MAO-B, β-secretase and γ-secretase, were studied by molecular docking, resulting in the finding that kaempferol, quercetin, and luteolin have multitarget p… Show more

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Cited by 4 publications
(3 citation statements)
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“…Ginkgo leaf extracts are generally reported to have antioxidant activity [48,49], and according to our results, the antioxidant activity measured by the DPPH method was not affected by the drying method. This is probably due to the similar content of polyphenols and flavonoids in the leaves dried by different methods, which are recognized as potent antioxidants [50].…”
Section: Discussionsupporting
confidence: 76%
“…Ginkgo leaf extracts are generally reported to have antioxidant activity [48,49], and according to our results, the antioxidant activity measured by the DPPH method was not affected by the drying method. This is probably due to the similar content of polyphenols and flavonoids in the leaves dried by different methods, which are recognized as potent antioxidants [50].…”
Section: Discussionsupporting
confidence: 76%
“…From the metabolites reported in the literature, the targets were obtained using the SwissTargetPrediction platform (STP). In this way, the construction of the frequency diagram was possible, according to the methodology previously reported for performing a frequency analysis on a set of metabolites from studies [11,12].…”
Section: Studies Of Similar Structuresmentioning
confidence: 99%
“…Proteins were prepared using Protein Preparation Wizard [21] according to the methodology. Molecular docking was performed on the Glide [22] module with flexibility at the site and using the ligands according to the reported protocol [12,23].…”
Section: Molecular Docking Studiesmentioning
confidence: 99%