Ginkgo biloba (EGB 761) improves microcirculation after warm ischemia of the rat liver

Topp, Stefan A.; Knoefel, Wolfram Trudo; Schutte, A. R.; Brilloff, Silke; Rogiers, Xavier; Gundlach, M.

doi:10.1016/s0041-1345(00)02295-8

Cited by 12 publications

(9 citation statements)

References 2 publications

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“…Bahcecioglu et al [29] reported that EGb761 reduces the increases in liver TBARS levels and serum ALT and AST activities caused by carbon tetrachloride in rats, and they suggested that its protective effect against carbon tetrachlorideinduced liver damage may be due to its capacity to reduce lipid peroxidation. EGb761 has also been shown to exhibit an effective oxygen radical scavenging activity, which improves hepatic microcirculation in the rat liver after warm ischaemia [11]. In the present study, pretreatment with the EGb761 had a beneficial effect on tissue 8-OHdG levels in rats of groups 3 and 4 compared to control rats.…”

Section: Discussionsupporting

confidence: 56%

“…There are several studies in which the protective effects of NAC on hepatic IR injury have been investigated, but the findings do not seem to be conclusive [6][7][8][9][10]. EGb761 is an extract of Ginkgo biloba standardized to 24% ginkgo-flavone glycosides and 6% terpenoids, both of which are known to scavenge hydroxyl (HO -), peroxide (HOO -) and superoxide radicals (O 2 -) [11]. Recent studies have provided considerable support for the in vitro and in vivo protective effects of EGb761 in IR injury [12].…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of N-acetylcysteine and Ginkgo biloba extract on ischaemia-reperfusion-induced hepatic DNA damage in rats

et al. 2008

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Hepatic ischaemia-reperfusion injury is a serious problem that occurs during various surgical operations such as liver transplantation, surgical revascularization, and partial organ resection. Different pharmacological agents have been used for the protection of organ function and for extending the tolerable ischaemic interval after the ischaemic insult. We aimed to determine the presence of 8-hydroxydeoxyguanosine (8-OHdG) in the DNA from liver undergoing ischaemia-reperfusion, and also to evaluate the protective effects of N-acetylcysteine (NAC) and EGb761 (Ginkgo biloba extract) against hepatic oxidative DNA damage. A total of 40 rats were divided into four groups of 10 animals each (sham-operation group, control group, NAC group, and EGb761 group). Oxidative damage to DNA was evaluated by measuring the increase in 8-OHdG formation in liver tissue and also the effects of NAC and EGb761 pretreatment. Hepatic ischaemia for 90 min followed by reperfusion caused a marked increase in tissue levels of 8-OHdG, thiobarbituric acid-reactive substance, serum ALT, AST and LDH activities compared to sham-operated group. Pretreatment with both NAC and EGb761 clearly diminished 8-OHdG formation and lipid peroxidation. These findings suggest that antioxidant molecules such as NAC and EGb761 may be useful in preventing postischaemic reperfusion injury in hepatic tissue.

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Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Protective effects of N-acetylcysteine and Ginkgo biloba extract on ischaemia-reperfusion-induced hepatic DNA damage in rats

et al. 2008

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“…Moreover, the extract and its ingredients (especially ginkgolide C) exhibit a potent antagonistic effect on platelet-activating factor and the inhibitory effect on expression of iNOS as well as nitric oxide production [16,17] . Several reports have shown that G. biloba protects I-R injury of the heart, brain, intestine, kidney and liver [15,[18][19][20][21] . Up to now, we have not found a study in the literature which evaluates the properties of G. biloba in the bladder.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effects of <i>Ginkgo biloba</i> Extract on Ischemia-Reperfusion Injury in Rat Bladder

Yenilmez

Kılıç²,

Sırmagül³

et al. 2007

Urol Int

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Aims: The aim of this experimental study was to evaluate the effects of Ginkgo biloba (EGb 761) on ischemia-reperfusion (I-R) injury in the rat bladder. Methods: A bladder I-R injury was induced by abdominal aorta occlusion by ischemia for 30 min, followed by 45 min reperfusion in rats. The rats were divided into four groups of 7 rats each; the control, I-R, and I-R groups were pretreated intraperitoneally with 50 or 100 mg/kg G. biloba 60 min before ischemia induction. Contractile responses to carbachol through isolated organ bath studies were recorded, histological sections were evaluated by light microscopy, and TUNEL staining was performed for the evaluation of apoptosis. Results: In the I-R group, the contractile responses of the bladder strips were lower than those of the control group (p < 0.01–0.001) and were restored by pretreatment with 100 mg/kg G. biloba (p < 0.05–0.001). Decreased polymorphonuclear leukocyte infiltration was detected in the G. biloba pretreatment groups when compared to the I-R group during histological evaluation. The ratio of TUNEL-positive nuclei was 1.84% in the I-R group, whereas it was decreased in both of the G. biloba pretreatment groups (p < 0.01, p < 0.01). Conclusion: Our data indicated that G. biloba has a preventive effect on I-R injury in rat urinary bladder.

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“…Taylor, 1986;Ramassamy et al, 1992;Huguet et al, 1994;Kristoikova and Klaschka, 1997), beneficial effects on blood circulation (e.g. Jung et al, 1990;Koltringer et al, 1993;Krieglstein et al, 1986;Chung et al, 1999;Topp et al, 2001), both in vitro and in vivo protection against hypoxic challenges (e.g. Oberpichler et al, 1988;Klein et al, 1997;Jannsens et al, 1999) and in vivo neuro-protective human psychopharmacology Hum.…”

Section: Introductionmentioning

confidence: 99%

Acute cognitive effects of standardised Ginkgo biloba extract complexed with phosphatidylserine

Kennedy

Haskell

Mauri

et al. 2007

Human Psychopharmacology

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Recent data suggest that the complexation of standardised Ginkgo biloba extract (GBE) with soy-derived phospholipids enhances the bioavailability of GBE's active components. The current study therefore aimed to assess the comparative cognitive and mood effects of a low dose of GBE and products complexing the same extract with either phosphatidylserine or phosphatidylcholine. The study utilised a placebo-controlled, multi-dose, double-blind, balanced-crossover design. Twenty-eight healthy young participants received 120 mg GBE, 120 mg GBE complexed with phosphatidylserine (Virtiva), 120 mg GBE complexed with phosphatidylcholine and a matching placebo, on separate days 7 days apart. Cognitive performance was assessed using the Cognitive Drug Research (CDR) computerised test battery and Serial Subtraction tasks immediately prior to dosing and at 1, 2.5, 4 and 6 h thereafter. The primary outcome measures were the four aspects of cognitive performance, which have previously been derived by factor analysis of CDR subtests. Levels of terpenoids (bilobalide, ginkgolide A and ginkgolide B) were concomitantly assessed in plasma samples taken pre-dose and at 3 and 6.5 h post-dose.In keeping with previous research utilising the same methodology, 120 mg of GBE was not associated with markedly improved performance on the primary outcomes. However, administration of GBE complexed with phosphatidylserine resulted both in improved secondary memory performance and significantly increased speed of memory task performance across all of the post-dose testing sessions. Enhancement following GBE complexed with phosphatidylcholine was restricted to a modest improvement in secondary memory performance which was restricted to one post-dose time point. All three treatments were associated with improved calmness. There were no significant differences in post-dose levels of terpenoids between the Ginkgo containing treatments, although this latter finding may be attributable to methodological factors. Complexation with phosphatidylserine appears to potentiate the cognitive effects associated with a low dose of GBE. Further research is required to identify whether this effect is due to the complexation of the extracts, their mere combination, or the separate psychopharmacological actions of the two extracts.

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Ginkgo biloba (EGB 761) improves microcirculation after warm ischemia of the rat liver

Cited by 12 publications

References 2 publications

Protective effects of N-acetylcysteine and Ginkgo biloba extract on ischaemia-reperfusion-induced hepatic DNA damage in rats

Protective effects of N-acetylcysteine and Ginkgo biloba extract on ischaemia-reperfusion-induced hepatic DNA damage in rats

Preventive Effects of <i>Ginkgo biloba</i> Extract on Ischemia-Reperfusion Injury in Rat Bladder

Acute cognitive effects of standardised Ginkgo biloba extract complexed with phosphatidylserine

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