Ginkgo biloba extracts-loaded starch nano-spheres: Preparation, characterization, and in vitro release kinetics

Wang, Tao; Wu, Caie; Fan, Gongjian; Li, Ting‐Ting; Gong, Hao; Cao, Fuliang

doi:10.1016/j.ijbiomac.2017.08.012

Cited by 38 publications

(20 citation statements)

References 44 publications

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“…Concerns still remain over the fate and behaviour of nano‐sized particles in the human body as limited published studies exist. Long‐term studies need to be undertaken for evaluation of potential toxicology or bioaccumulation that theoretically could be detrimental in human systems (Recharla et al ., ; Shishir et al ., ; Temelli, ; Wang et al ., ).…”

Section: Baked Goods As Functional Foodsmentioning

confidence: 97%

Ensuring the future of functional foods

Birch

Bonwick

2018

Int J of Food Sci Tech

129

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Consumption of functional foods suggests a strategy to reduce the incidence of chronic health disorders. This message has resonated with consumers and driven market growth. Functional food research has significantly increased over the last decade but few studies have addressed the bioavailability of active ingredients for clinical efficacy. Baked goods such as bread, biscuits and cake are popular categories for innovation due to their widespread consumption. These new developments have often impacted on organoleptic properties of the finished products and thus consumer acceptance. Blending of bioactive ingredients may overcome this deficit. However, an understanding of the role of the microbiome in health has indicated that the efficacy of functional foods is unlikely to be uniform within the population. Further growth in the functional foods market, is likely to require greater evidence of the bioavailability of active ingredients, clinical effect and support for health claims by regulators especially in the EU.

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Section: Baked Goods As Functional Foodsmentioning

confidence: 97%

Ensuring the future of functional foods

Birch

Bonwick

2018

Int J of Food Sci Tech

129

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“…141,142 The main virtue of this system includes delayed drug release, regular plasma drug concentrations, more stability in biological fluids, high protection from enzymatic and chemical degradation, improved bioavailability, potential antitumor efficiency, enhance complete entrapment of the drug, and reduced toxicity. 143 These most outstanding features of NS are directly due to hydrophobic surfaces of these particles that are highly susceptible to opsonization and clearance by the reticuloendothelial system. 12 Biodegradable NS includes albumin NS, modified starch NS, gelatin NS, polypropylene dextran NS and polylactic acid NS.…”

Section: Micellementioning

confidence: 99%

“…146 More examples of herbal loaded NE are presented in Table 1. 142,143,[147][148][149] Nanocrystals They are pure drug crystals with nanosized particles (Figure 9) in which toxic side effects resulting from the encapsulating/solubilizing excipients may be eliminated. 150 The best known features of nanocrystals are high drug-loading capacity and platform stability that render them to be widely used to deliver poorly hydrophilic materials in the form of a colloidal dispersion.…”

Section: Micellementioning

confidence: 99%

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Rahman

Othman

Hammadi

et al. 2020

IJN

156

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Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

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“…In order to improve the oral bioavailability of GBE, many strategies have been studied, including the methods of self-emulsifications (Tang et al, 2008;Gu et al, 2017), solid dispersions (Wang et al, 2015), phospholipid complexes (Chen et al, 2010;Zheng et al, 2016), and preparing nanoparticles (Zhao et al, 2011;Wang et al, 2016Wang et al, , 2018. The method of preparing nanoparticles has been proved to be an effective technology to improve the bioavailability of GBE.…”

Section: Introductionmentioning

confidence: 99%

Enhanced bioaccessibility in vitro and bioavailability of Ginkgo biloba extract nanoparticles prepared by liquid anti‐solvent precipitation

Wang

Zhao

Yang

et al. 2019

Int J of Food Sci Tech

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Summary The ginkgo biloba extract (GBE) nanoparticles were successfully prepared by adopting the liquid anti‐solvent precipitation (LASP) method to enhance the antioxidant activity and oral bioavailability of GBE. Under the optimum preparation conditions, the particle size of GBE nanoparticles had reached 76.90 nm. Moreover, the antioxidant activity and intestinal transmittance of GBE nanoparticles were tested before and after the simulated in vitro digestion, which were both significantly higher than that of raw GBE. Significantly, the AUC(0→t) value of flavonoids and terpene lactones in GBE nanoparticles were 2.20 and 2.24 times of that in raw GBE, respectively. What cannot be ignored was that the residual amount of ethanol and n‐hexane meets the safety standards for food.

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Ginkgo biloba extracts-loaded starch nano-spheres: Preparation, characterization, and in vitro release kinetics

Cited by 38 publications

References 44 publications

Ensuring the future of functional foods

Ensuring the future of functional foods

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Enhanced bioaccessibility in vitro and bioavailability of Ginkgo biloba extract nanoparticles prepared by liquid anti‐solvent precipitation

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