Ginkgo biloba special extract EGb 761 in the treatment of peripheral arterial occlusive disease (PAOD)  a review based on randomized, controlled studies

Hörsch, S.; Walther, C

doi:10.5414/cpp42063

Cited by 38 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lactone acts as a PAF antagonist and improves blood rheology, modulates neurotransmitter release, increases oxygen and glucose supply of ischemic tissues and lowers blood viscosity. Two randomized, double-blind, placebo-controlled trials (Schneider et al, 2005;Horsch and Walther, 2004) proved that EGb could improve cognitive performance of patients with Alzheimer's disease and the outcome of patients with peripheral arterial occlusive disease. Zeybek et al(2003) found prophylactic application of EGb caused significant decrease in serum amylase and lipase levels compared with the control group.…”

Section: Ginkolide Bmentioning

confidence: 99%

Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis

Zhang

Liu

Shi

2007

J. Zhejiang Univ. - Sci. B

View full text Add to dashboard Cite

Abstract:Severe acute pancreatitis (SAP) is a common acute abdomen clinical problem characterized by high mortality, multiple complications, complicated pathogenesis and difficult treatment. Recent studies found traditional Chinese medicine (TCM) monomers have markedly good effect for treating SAP. Many TCM monomers can inhibit pancreatin, resist inflammation, improve microcirculation and immunoloregulation, etc. to block the pathological progress of SAP in multiple ways, reduce complications and lower mortality with rapid effects. It is significant for enhancing SAP treatment to deeply understand the current situation in TCM monomers for treating SAP and take precious references therein. This article summarizes the treating effects and mechanisms of TCM monomers for SAP in recent years.

show abstract

Section: Ginkolide Bmentioning

confidence: 99%

Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis

Zhang

Liu

Shi

2007

J. Zhejiang Univ. - Sci. B

View full text Add to dashboard Cite

show abstract

“…There is a registered medicine on the market containing G. biloba , Tavonin®, which is used for patients that don't respond (enough) to walking exercise (16). In patients with claudicatio intermittens, a positive effect at a dose of 120 mg/day was seen in two meta-analyses (21, 22). However, a recent systematic review that included 739 patients from 14 trials (with different dosage and duration of treatment) didn't find a significant effect on walking distance in people with claudication intermittens (23).…”

Section: Resultsmentioning

confidence: 99%

Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba

Fransen

Pelgrom

Stewart-Knox

et al. 2010

Food & Nutrition Research

View full text Add to dashboard Cite

BackgroundEuropean Regulation 1924/2006 states that all health claims made on foods need to be substantiated scientifically.ObjectiveTo apply the PASSCLAIM criteria for the scientific substantiation of health claims on foods to herbal supplements containing Ginkgo biloba. Evaluation of three selected claimed health effects for G. biloba (improvement of blood circulation, improvement of symptoms of old age, and improvement of memory) was achieved through review of publicly available scientific data. A total of 35 human intervention studies were evaluated. Commercially available products claimed to contain mainly G. biloba (N=29) were randomly sampled in the Netherlands and analyzed for their content on ginkgo extract. Also, a toxicological risk assessment was performed.ResultsThe three selected health claims investigated could not be substantiated. This was mainly because of a lack of data from studies in healthy volunteers. In most studies results performed with a 24% standardized G. biloba extract were described. However, our chemical analysis showed that 25 of the 29 sampled products did not contain the required minimum 24% standardized extract. Moreover, in most preparations the content of substances typical for G. biloba did not conform to what was declared on the label. Since toxicity data for G. biloba are very limited, a safety limit could not be established.ConclusionsEvidence is lacking for three health claims of herbal products with G. biloba. Neither safety nor efficacy can be guaranteed at the recommended daily dose. The multidisciplinary approach described in this paper provides good insight into issues that are relevant for the evaluation of health claims for herbal food supplements.

show abstract

“…On the other hand, histamine analogs have been associated with side effects, such as drowsiness and dry mouth, especially in elderly patients. Vasoactive effects have also been demonstrated for Ginkgo biloba extracts, which cause vasorelaxation in precontracted isolated rat thoracic aortic rings by stimulation of endothelial NO production [19] and exert considerable therapeutic effects in patients with peripheral arterial occlusive disease [11].…”

Section: Discussionmentioning

confidence: 98%

The low-dose combination preparation Vertigoheel activates cyclic nucleotide pathways and stimulates vasorelaxation

Heinle

Tober²,

Zhang

et al. 2010

Clinical Hemorheology and Microcirculation

View full text Add to dashboard Cite

Vertigo of various and often unknown aetiologies has been associated with and attributed to impaired microvascular perfusion in the inner ear or the vertebrobasilar system. Vertigoheel is a low-dose combination preparation of proven value in the symptomatic treatment of vertigo. In the present study we tested the hypothesis that Vertigoheel's anti-vertiginous properties may in part be due to a vasodilatory effect exerted via stimulation of the adenylate and/or guanylate cyclase pathways. Thus, the influence of Vertigoheel or its single constituents on synthesis and degradation of cyclic nucleotides was measured. Furthermore, vessel myography was used to observe the effect of Vertigoheel on the vasoreactivity of rat carotid arteries. Vertigoheel and one of its constituents, Anamirta cocculus, stimulated adenylate cyclase activity, while another constituent, Conium maculatum, inhibited phosphodiesterase 5, suggesting that the individual constituents of Vertigoheel contribute differentially to a synergistic stimulation of cyclic nucleotide signalling pathways. In rat carotid artery rings, Vertigoheel counteracted phenylephrine-induced tonic vasoconstriction. The present data demonstrate a vasorelaxant effect of Vertigoheel that goes along with a synergistic stimulation of cyclic nucleotide pathways and may provide a mechanistic basis for the documented anti-vertiginous effects of this combination preparation.

show abstract

Ginkgo biloba special extract EGb 761 in the treatment of peripheral arterial occlusive disease (PAOD) a review based on randomized, controlled studies

Cited by 38 publications

References 0 publications

Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis

Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis

Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba

The low-dose combination preparation Vertigoheel activates cyclic nucleotide pathways and stimulates vasorelaxation

Contact Info

Product

Resources

About

Ginkgo biloba special extract EGb 761 in the treatment of peripheral arterial occlusive disease (PAOD)  a review based on randomized, controlled studies

Cited by 38 publications

References 0 publications

Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis

Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis

Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba

The low-dose combination preparation Vertigoheel activates cyclic nucleotide pathways and stimulates vasorelaxation

Contact Info

Product

Resources

About

Ginkgo biloba special extract EGb 761 in the treatment of peripheral arterial occlusive disease (PAOD) a review based on randomized, controlled studies