Ginkgo biloba supplement abates lead-induced endothelial and testicular dysfunction in Wistar rats via up-regulation of Bcl-2 protein expression, pituitary-testicular hormones and down-regulation of oxido-inflammatory reactions

Asiwe, Jerome Ndudi; Ekene, Enekabokom Nwoke; Agbugba, Linda Chinyere; Moke, Emuesiri Goodies; Akintade, Abimbola Victoria; Ben-Azu, Benneth; Eruotor, Harrison; Daubry, Tarela Melish Elias; Anachuna, Kenneth Kelechi; Oyovwi, Mega O.

doi:10.1016/j.jtemb.2023.127216

Cited by 9 publications

(1 citation statement)

References 79 publications

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“…Additionally, YY162, consisting of Rg3 extracted from P. ginseng C. A. Mey. and Ginkgo biloba L. ( Ben-Azu et al, 2022b ; Asiwe et al, 2023 ), exerted protective activity on ADHD through modulating oxidative metabolism and the BDNF/TrkB pathway ( Nam et al, 2014 ). Yet, the mechanism of Rg3 on ADHD requires further research and exploration.…”

Section: Pharmacological Action Of Rg3 In Mental Disordersmentioning

confidence: 99%

The protective role of ginsenoside Rg3 in heart diseases and mental disorders

Shi,

Luo,

Wei

et al. 2024

Front. Pharmacol.

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Ginsenoside Rg3, a compound derived from Panax ginseng C. A. Mey., is increasingly recognized for its wide range of pharmacological effects. Under the worldwide healthcare challenges posed by heart diseases, Rg3 stands out as a key subject in modern research on Chinese herbal medicine, offering a novel approach to therapy. Mental illnesses are significant contributors to global disease mortality, and there is a well-established correlation between cardiac and psychiatric conditions. This connection is primarily due to dysfunctions in the sympathetic-adrenomedullary system (SAM), the hypothalamic-pituitary-adrenal axis, inflammation, oxidative stress, and brain-derived neurotrophic factor impairment. This review provides an in-depth analysis of Rg3’s therapeutic benefits and its pharmacological actions in treating cardiac and mental health disorders respectively. Highlighting its potential for the management of these conditions, Rg3 emerges as a promising, multifunctional therapeutic agent.

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Section: Pharmacological Action Of Rg3 In Mental Disordersmentioning

confidence: 99%

The protective role of ginsenoside Rg3 in heart diseases and mental disorders

Shi,

Luo,

Wei

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

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Therapeutic Potential of Chinese Herbal Medicine and Underlying Mechanism for the Treatment of Myocardial Infarction

Pan,

Wang,

Lei

et al. 2024

Phytotherapy Research

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Myocardial infarction (MI) is a prevalent disease with high mortality rates worldwide. The course of MI is intricate and variable, necessitating personalized treatment strategies based on different mechanisms. However, variety of postoperative complications and rejections, such as heart failure, arrhythmias, cardiac rupture, and left ventricular thrombus, contribute to a poor prognosis. Despite the inclusion of antiplatelet agents and statins in the conventional treatment regimen, their clinical applicability is constrained by potential adverse effects and limited efficacy. Additionally, the mechanisms leading to MI are complex and diverse. Therefore, the development of novel compounds for MI treatment. The use of traditional Chinese medicine (TCM) in the prevention and treatment of cardiovascular diseases, including MI, is grounded in its profound historical background, comprehensive theoretical system, and accumulated knowledge. An increasing number of contemporary evidence‐based medical studies have demonstrated that TCM plays a significant role in alleviating symptoms and improving the quality of life for MI patients. Chinese herbal formulations and active ingredients can intervene in the pathological process of MI through key factors such as inflammation, oxidative stress, apoptosis, ferroptosis, pyroptosis, myocardial fibrosis, angiogenesis, and autophagy. This article critically reviews existing herbal formulations from an evidence‐based medicine perspective, evaluating their research status and potential clinical applications. Additionally, it explores recent advancements in the use of herbal medicines and their components for the prevention and treatment of MI, offering detailed insights into their mechanisms of action.

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