Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay

Xiang, Yusen; Zhai, Guanglei; Li, Yaozong; Wang, Mengge; Chen, Xixiang; Wang, Ruyu; Xie, Hang; Zhang, Weidong; Ge, Guang-Bo; Zhang, Qian; Xu, Yechun; Caflisch, Amedeo; Xu, Jianrong; Chen, Hongzhuan; Chen, Lili

doi:10.1016/j.ijbiomac.2022.12.057

Cited by 7 publications

(7 citation statements)

References 66 publications

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“…Our data demonstrating that GA only affect viral entry is in line with observations reported for several viral pathogens 34 , 36 , 40 , which also did not report any post-entry anti-viral activity. Yet, for some other viruses GA was shown to have post-entry antiviral activity 37 – 39 , 41 .…”

Section: Discussionsupporting

confidence: 93%

“…The difference in GA potency on hRSV compared to hMPV infectivity (Figs. 2 and 4 ) hints that although GA seems to be a pan-acting entry inhibitor of many viruses 34 , 37 , 40 , 47 , some specificity to viral glycoproteins exists. This raises the possibility that modifications of GA might improve its antiviral efficacy making it a better pan-acting antiviral at lower concentration.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, using a virus-free model of virus-cell fusion by expressing viral fusion proteins on target cells and monitoring cell-to-cell fusion events, GA treatment was demonstrated to prevent the fusion of cells expressing the fusion proteins of Zika virus, HIV-1, Ebola virus, influenza A virus, Semliki Forest virus, Venezuelan equine encephalitis virus, vesicular stomatitis virus, and Epstein Barr virus 36 . Recently, GA treatment was also reported to block the interaction between the viral glycoprotein of the Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2)—the spike protein—and its host cell receptor ACE2, thus preventing viral entry 40 . GA was also shown to inhibit the proteolytic activities of the HIV-1 protease 39 and the main protease of SARS-CoV-2 (the 3CLpro) 38 , 41 .…”

Section: Introductionmentioning

confidence: 99%

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Ginkgolic acid inhibits orthopneumo- and metapneumo- virus infectivity

Luck,

Subillaga,

Borenstein

et al. 2024

Sci Rep

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The human respiratory syncytial virus (hRSV) and the human metapneumovirus (hMPV) are important human respiratory pathogens from the Pneumoviridae family. Both are responsible for severe respiratory tract infections in infants, young children, elderly individuals, adults with chronic medical conditions, and immunocompromised patients. Despite their large impact on human health, vaccines for hRSV were only recently introduced, and only limited treatment options exist. Here we show that Ginkgolic acid (GA), a natural compound from the extract of Ginkgo biloba, with known antiviral properties for several viruses, efficiently inhibits these viruses’ infectivity and spread in cultures in a dose-dependent manner. We demonstrate that the drug specifically affects the entry step during the early stages on the viruses’ life cycle with no effect on post-entry and late stage events, including viral gene transcription, genome replication, assembly and particles release. We provide evidence that GA acts as an efficient antiviral for members of the Pneumoviridae family and has the potential to be used to treat acute infections.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ginkgolic acid inhibits orthopneumo- and metapneumo- virus infectivity

Luck,

Subillaga,

Borenstein

et al. 2024

Sci Rep

View full text Add to dashboard Cite

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“…In this bibliometric study, we used VOSviewer to draft a keyword co-occurring visualization map, in which the size of the nodes indicates the cooccurring frequency and the color of the nodes indicates the cluster. Furthermore, the link reveals the co-occurrence relationship, and the thickness of the link depends on a calculated strength value, which is proportionate to the number of publications two researchers coauthored or the number of publications in which two keywords occur together (31). In density maps, the keywords of high co-occurrence appear with larger spots.…”

Section: Data Analysismentioning

confidence: 99%

“…The largest cluster is "myocardial injury" (cluster #0), followed by "angiotensin-converting enzyme" (cluster #1), "regenerative medicine" (cluster #2), and "COVID-19 pandemic" (cluster #3). It is not surprising that myocardial injury and angiotensin-converting enzyme are hot topics in the field of CVDs in COVID-19, as myocardial injury has a relatively high incidence in COVID-19 patients (54-56) and the interaction between the spike protein receptor-binding domain of SARS-CoV-2 and angiotensinconverting enzyme 2 is a significant link in the pathogenesis of COVID-19 (31,57). We further explored "regenerative medicine" as scholars are studying the effect of targeted protein S-nitrosylation of ACE2 (58) and medicines such as optimized ACE2 decoys (59) in the treatment of COVID-19, reflecting peoples' focus on COVID-19 therapies.…”

Section: Keyword Analysismentioning

confidence: 99%

Bibliometric evaluation of 2020–2022 publications on COVID-19-related cardiovascular disease

Chen

Cao

Zhou

et al. 2023

Front. Cardiovasc. Med.

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ObjectiveThis study aimed to investigate the international scientific output regarding the relationship between COVID-19 and cardiovascular diseases (CVDs) through a bibliometric analysis and explore research hotspots in this field.MethodsWe searched the Web of Science Core Collection for publications and used different types of software, such as R, CiteSpace, and VOSviewer, to analyze and visualize the data.ResultsA total of 10,055 publications were retrieved as of the 13 December 2022, based on the inclusion criteria after screening. The USA and China lead in the quantity and quality of publications in this field. Based on Bradford's law, 63 journals were considered core journals in the field. Co-cited references and keywords analysis indicated that researchers paid particular attention to cardiovascular comorbidities, outcomes, and COVID-19 regenerative medicine. In summary, with increasing COVID-19 research related to CVD, more attention might be drawn to the relationship between these two diseases.ConclusionThe hotspots in this field may continue to revolve around cardiovascular comorbidities, outcomes, and COVID-19 regenerative medicine. Owing to the different situations faced by different groups with COVID-19, further exploration of the related factors specific to each of these groups, e.g., history or no history of heart failure, is needed, with a view to providing a reference for intervention measures in COVID-19 research.

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Advancing Scaffold‐Assisted Modality for In Situ Osteochondral Regeneration: A Shift From Biodegradable to Bioadaptable

Wu,

Wang,

Wang

et al. 2024

Advanced Materials

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Over the decades, the management of osteochondral lesions remains a significant yet unmet medical challenge without curative solutions to date. Owing to the complex nature of osteochondral units with multi‐tissues and multicellularity, and inherently divergent cellular turnover capacities, current clinical practices often fall short of robust and satisfactory repair efficacy. Alternative strategies, particularly tissue engineering assisted with biomaterial scaffolds, achieve considerable advances, with the emerging pursuit of a more cost‐effective approach of in situ osteochondral regeneration, as evolving toward cell‐free modalities. By leveraging endogenous cell sources and innate regenerative potential facilitated with instructive scaffolds, promising results are anticipated and being evidenced. Accordingly, a paradigm shift is occurring in scaffold development, from biodegradable and biocompatible to bioadaptable in spatiotemporal control. Hence, this review summarizes the ongoing progress in deploying bioadaptable criteria for scaffold‐based engineering in endogenous osteochondral repair, with emphases on precise control over the scaffolding material, degradation, structure and biomechanics, and surface and biointerfacial characteristics, alongside their distinguished impact on the outcomes. Future outlooks of a highlight on advanced, frontier materials, technologies, and tools tailoring precision medicine and smart healthcare are provided, which potentially paves the path toward the ultimate goal of complete osteochondral regeneration with function restoration.

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Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay

Cited by 7 publications

References 66 publications

Ginkgolic acid inhibits orthopneumo- and metapneumo- virus infectivity

Ginkgolic acid inhibits orthopneumo- and metapneumo- virus infectivity

Bibliometric evaluation of 2020–2022 publications on COVID-19-related cardiovascular disease

Advancing Scaffold‐Assisted Modality for In Situ Osteochondral Regeneration: A Shift From Biodegradable to Bioadaptable

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