Ginkgolide B treatment regulated intestinal flora to improve high-fat diet induced atherosclerosis in ApoE−/− mice

Lv, Zhiyang; Shan, Xin; Tu, Qing-Bo; Wang, Jie; Chen, Jing; Yang, Yuwei

doi:10.1016/j.biopha.2020.111100

Cited by 36 publications

(27 citation statements)

References 37 publications

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“…Through Metastats analysis, the composition proportion of different species can be evaluated from different species levels, and species changes brought by ALE can be intuitively reflected in combination with the comparison of key species differences. In this experiment, it can be seen that Firmicutes and Bacteroidetes were the dominant bacteria in mouse intestine, which conformed to the composition rule of normal mice [ 27 ]. Generally speaking, Firmicutes are slightly more prevalent than Bacteroidetes in the intestinal flora of mice fed a normal diet.…”

Section: Discussionsupporting

confidence: 57%

An Extract of Artemisia argyi Leaves Rich in Organic Acids and Flavonoids Promotes Growth in BALB/c Mice by Regulating Intestinal Flora

Tan

Gong

et al. 2022

Animals

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In the context of global restrictions on the use of antibiotics, there has been increased research on natural plant-based ingredients as additives. It has been proved that many natural active ingredients contained in plants have positive effects on animal growth regulation. Artemisia argyi (A. argyi) is a traditional Chinese herbal medicine, and its extracts have been reported to have a variety of biological activities. Therefore, in order to explore the potential of the active extract of Artemisia argyi leaves (ALE) as a plant source additive, mice were fed with ALE at different concentrations for 60 days. Finally, the effects of ALE were evaluated by the growth indexes, blood indexes, and intestinal microflora changes of the mice. It was found that a medium concentration of ALE (150 mg/kg) could promote growth, and especially improved the feed efficiency of the mice. However, high concentrations of ALE (300 mg/kg) had some negative effects on the growth of mice, especially liver damage, which significantly increased AST and ALT levels in the blood. Therefore, the 150 mg/kg ALE treatment group was selected for 16S rDNA analysis. It was found that ALE could play a positive role by regulating the proportion of Bacteroidetes and Firmicutes in the intestinal tract. In particular, it can significantly up-regulate the quantities of Akkermansia and Bifidobacterium. These results suggest that ALE at appropriate concentrations can positively regulate animal growth.

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Section: Discussionsupporting

confidence: 57%

An Extract of Artemisia argyi Leaves Rich in Organic Acids and Flavonoids Promotes Growth in BALB/c Mice by Regulating Intestinal Flora

Tan

Gong

et al. 2022

Animals

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“…Ginkgolide B is an herbal component of the extract obtained from Ginkgo biloba (GB) leaves ( 87 ). Studies have shown that ginkgolide can reduce dyslipidemia, inflammation, and intestinal barrier dysfunction in ApoE −/− mice fed with a high-fat diet.…”

Section: Potential Therapeutic Measures Of Tmao For Asmentioning

confidence: 99%

Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy

Wang

Qiu

Lian

et al. 2021

Front. Cardiovasc. Med.

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Atherosclerosis is associated with various pathological manifestations, such as ischemic heart disease, ischemic stroke, and peripheral arterial disease, and remains a leading cause of public health concern. Atherosclerosis is an inflammatory disease characterized by endothelial dysfunction; vascular inflammation; and the deposition of lipids, cholesterol, calcium, and cellular debris within the vessel wall intima. In-depth studies of gut flora in recent years have shown that bacterial translocation and the existence of bacterial active products in blood circulation can affect the inflammatory state of the whole blood vessel. The gut flora is considered to be a large “secretory organ,” which produces trimethylamine-N-oxide (TMAO), short-chain fatty acids and secondary bile acids by breaking down the ingested food. Studies have shown that TMAO is an independent risk factor for the occurrence of malignant adverse cardiovascular events, but whether it is harmful or beneficial to patients with cardiovascular diseases with mild or no clinical manifestations remains controversial. We review the relationship between TMAO and its precursor (L-carnitine) and coronary atherosclerosis and summarize the potential molecular mechanism and therapeutic measures of TMAO on coronary atherosclerosis.

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“…In addition to the intervention strategies mentioned above, other strategies can also be used as potential approaches. Some traditional Chinese medicine are proved be able to lower TMAO concentrations, such as Alisma orientalis beverage (Zhu et al, 2020), Ginkgolide B (Lv et al, 2021), Berberine , etc. Besides, vitamins are other candidates for reducing TMAO concentrations, such as vitamin B and vitamin D (Obeid et al, 2017).…”

Section: Other Intervention Strategiesmentioning

confidence: 99%

Trimethylamine-N-Oxide Pathway: A Potential Target for the Treatment of MAFLD

Hong

Wang

et al. 2021

Front. Mol. Biosci.

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Trimethylamine-N-oxide (TMAO) is a molecular metabolite derived from the gut flora, which has recently emerged as a candidate risk factor for metabolic dysfunction-associated fatty liver disease (MAFLD). TMAO is mainly derived from gut, where the gut microbiota converts TMA precursors into TMA, which is absorbed into the bloodstream through the intestinal mucosa, and then transformed into TMAO by hepatic flavin monooxygenases (FMOs) in the liver. High-nutrient diets rich in TMA precursors, such as red meat, eggs, and fish, are the main sources of TMAO. Excessively consuming such diets not only directly affects energy metabolism in liver, but also increases the concentration of TMAO in plasma, which promotes the development of MAFLD by affecting bile acid metabolism, unfolded protein response, and oxidative stress. In this review, we focused on the relationship between TMAO and MAFLD and summarized intervention strategies for reducing circulating TMAO concentration, aiming at providing new targets for the prevention and treatment of MAFLD.

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Ginkgolide B treatment regulated intestinal flora to improve high-fat diet induced atherosclerosis in ApoE−/− mice

Cited by 36 publications

References 37 publications

An Extract of Artemisia argyi Leaves Rich in Organic Acids and Flavonoids Promotes Growth in BALB/c Mice by Regulating Intestinal Flora

An Extract of Artemisia argyi Leaves Rich in Organic Acids and Flavonoids Promotes Growth in BALB/c Mice by Regulating Intestinal Flora

Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy

Trimethylamine-N-Oxide Pathway: A Potential Target for the Treatment of MAFLD

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