Ginseng: A bibliometric analysis of 40-year journey of global clinical trials

Chen, Weijie; Yao, Peifen; Vong, Chi Teng; Li, Xiuzhu; Chen, Zhejie; Xiao, Jianbo; Wang, Shengpeng; Wang, Ying

doi:10.1016/j.jare.2020.07.016

Cited by 24 publications

(9 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, domestic and foreign scholars have conducted pharmacological studies, clinical observations, and epidemiological investigations on the effective ingredients of ginseng, and the results have confirmed that ginseng has improved microcirculation, improved tissue antihypoxia ability, and inhibited platelet aggregation, antitumor, and antiaging, antiradiation, antifatigue, and other biological activities. [ 27 , 28 ] In fatigue, previous studies have found that ginseng can improve thinking and physical activity. [ 29 , 30 ] However, large samples of clinical research data are insufficient.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis

Zhu

Zhang

et al. 2022

Medicine

View full text Add to dashboard Cite

Background: Ginseng has been believed to provide energy, physical health, and well-being to patients for hundreds of years. Fatigue is a multidimensional symptom with unknown etiology and varying severity, and lots of patients suffer from fatigue. Methods: We search for research of ginseng treatment of disease-related fatigue in adult patients in Pubmed, Embase, Medline, and Cochrane library. Two independent reviewers assessed included studies and met to develop consensus on included studies. And we used Review Manager 5.3 software to evaluate the risk of bias. Results: The present meta-analysis included 12 randomized controlled trial containing 1298 patients. In the fixed-effect meta-analysis of 12 randomized controlled trial, ginseng supplements had a statistically significant efficacy on disease-related fatigue reduction (standardized mean difference = 0.33, 95% confidence interval = 0.44–0.22). Conclusions: The use of ginseng supplements is benefit for patients to reduce disease-related fatigue.

show abstract

Section: Discussionmentioning

confidence: 99%

Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis

Zhu

Zhang

et al. 2022

Medicine

View full text Add to dashboard Cite

show abstract

“…In 2021, a systematic review aiming to include all clinical trials involving all forms of ginseng was published [141]. Of the 121 retained studies that evaluated safety, 41.6% reported no adverse events, 31.6% reported no significant difference between groups in adverse events, and 26.6% reported no serious adverse events [141]. Mild adverse events included dizziness, headaches, diarrhea, insomnia, hypoglycemia, and nausea [141].…”

Section: Safetymentioning

confidence: 99%

“…Of the 121 retained studies that evaluated safety, 41.6% reported no adverse events, 31.6% reported no significant difference between groups in adverse events, and 26.6% reported no serious adverse events [141]. Mild adverse events included dizziness, headaches, diarrhea, insomnia, hypoglycemia, and nausea [141]. Due to the scarcity of human research involving the ginseng berry and its extracts, establishing clinical safety remains essential.…”

Section: Safetymentioning

confidence: 99%

The Untapped Potential of Ginsenosides and American Ginseng Berry in Promoting Mental Health via the Gut–Brain Axis

St-Laurent

Hammami

2022

Nutrients

View full text Add to dashboard Cite

Despite the popularity of the ginseng (Panax) root in health research and on the market, the ginseng berry’s potential remains relatively unexplored. Implementing ginseng berry cultivations and designing berry-derived products could improve the accessibility to mental health-promoting nutraceuticals. Indeed, the berry could have a higher concentration of neuroprotective and antidepressant compounds than the root, which has already been the subject of research demonstrating its efficacy in the context of neuroprotection and mental health. In this review, data on the berry’s application in supporting mental health via the gut–brain axis is compiled and discussed.

show abstract

“…Recently, the focus on naturally-occurring bioactive for therapeutic purposes has grown, and specifically with concerns to neuropsychiatric treatment, an increasing amount of natural products formulations has become widespread with the main goal of avoiding or even decreasing the use of psychotropic drugs (W. Chen et al, 2021;Al Mamun et al, 2021;Shandilya et al, 2022). Many medicinal plants, their derived extracts and even isolated constituents have been addressed for their therapeutic abilities in ADHD, in vitro and in vivo experiments, and even clinical studies, with Acorus gramineus Aiton, Paecilomyces tenuipes, Rhodiola rosea L., Psoralea corylifolia L., Hypericum perforatum L., Valeriana officinalis L., Ginkgo biloba L. In an in vitro experiment, the bioactive compound α-asarone isolated from A. gramineus Aiton led to a reduction in the elevated acetylcholinesterase activity at the same time that increased the m1 muscarinic acetylcholine receptor expression (Qiu et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Natural products of relevance in the management of attention deficit hyperactivity disorder

Custódio

Vizetto‐Duarte

Cebeci

et al. 2022

eFood

View full text Add to dashboard Cite

Attention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders characterized by motor hyperactivity, attention deficit, distraction, impulsive behavior, and relationship difficulties. It affects children, and thus over the years, there has been growing attention on the use of natural product formulations and their naturally-occurring bioactive for overcoming the problem of ADHD. Concerning this issue, this review aims to discuss the ADHD treatment potential of natural products/formulations in vitro, in vivo as well as in clinical trials. To gather the most relevant data regarding bioactive compounds with potential therapeutic effects in the management of ADHD, the following databases were searched: PubMed/MedLine, ScienceDirect, and Google Scholar for articles in English. Various medicinal plants and their isolated biomolecules have been evaluated in vitro, in vivo, and in clinical trials for their ability to treat ADHD. Most of the analyzed research results showed an improvement of ADHD signs and symptoms in in vivo models, but the molecular mechanisms of action of the bioactive compounds are unclear and incompletely elucidated. Further studies are needed to determine the bioactive compound responsible for health-promoting effects in ADHD. In addition, clinical studies should be performed over longer periods with more participants.

show abstract

Ginseng: A bibliometric analysis of 40-year journey of global clinical trials

Abstract: Graphical abstract

Cited by 24 publications

References 66 publications

Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis

Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis

The Untapped Potential of Ginsenosides and American Ginseng Berry in Promoting Mental Health via the Gut–Brain Axis

Natural products of relevance in the management of attention deficit hyperactivity disorder

Contact Info

Product

Resources

About