Ginseng as a Treatment for Fatigue: A Systematic Review

Arring, Noël; Millstine, Denise; Marks, Lisa; Nail, Lillian M.

doi:10.1089/acm.2017.0361

Cited by 86 publications

(57 citation statements)

References 22 publications

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“…e most frequently studied ginseng is Panax ginseng C. A. Meyer (Asian ginseng or Korean ginseng) [131]. Ginseng and its chemical constituents have exhibited various beneficial effects, which include antioxidant, anti-inflammatory, antiapoptotic, anticancer, antifatigue, antidiabetic, and antiaging [132][133][134][135][136][137][138][139]. Apart from that, ginseng and its constituents are also known to have a beneficial effect on the central nervous system [140][141][142][143].…”

Section: Ginseng Ginseng Is a Perennial Herb Belonging To Thementioning

confidence: 99%

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Sairazi

Sirajudeen

2020

Evidence-Based Complementary and Alternative Medicine

142

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In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases.

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Section: Ginseng Ginseng Is a Perennial Herb Belonging To Thementioning

confidence: 99%

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Sairazi

Sirajudeen

2020

Evidence-Based Complementary and Alternative Medicine

142

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“…In addition, ginseng has been known as a natural sexual enhancer (33). This feature may result from an increase in physical energy due to the ginseng anti-fatigue effect (34).…”

Section: Mortalities and Morbiditiesmentioning

confidence: 99%

“…The reason for this choice is its multi-target and multi-purpose property (35). Various therapeutic effects of ginseng in conditions like the quality of life (36), Alzheimer's disease (37), common cold (38), diabetes mellitus (39), hypertension (40) and cardiovascular disease (31), anti-fatigue effect (34), and erectile dysfunction (41) were evaluated in different studies.…”

Section: Mortalities and Morbiditiesmentioning

confidence: 99%

A Meta-Analysis of the Efficacy of Panax Ginseng on Menopausal Women’s Sexual Function

Ghorbani

Mirghafourvand

2018

International Journal of Women’s Health and Reproduction Scienc

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Objectives: An increase in life expectancy results in the aging population growth. This study was designed to evaluate the efficacy and adverse events of ginseng that could be used as a herbal medicine in women with sexual dysfunction. Materials and Methods: The authors of this study searched Cochrane Library, MEDLINE, Web of Science, Embase, Scopus, ProQuest, Google Scholar, and Persian databases without a time limitation until May 2018 and examined all the randomized clinical trials (RCTs) that compared the effect of different types of ginseng on sexual function of menopausal women as compared to the placebo controls. The Cochrane risk of bias tool was used to assess the methodological quality of the included studies. The heterogeneity was determined using the I2 index. In addition, standardized mean difference (SMD) was used instead of mean differences (MD) and a random effect was reported instead of fixed effect in meta-analysis. Results: The eligibility criteria were found in five RCTs. All the included studies were placebo-controlled. Two trials had a parallel design while three studies used a crossover design. Although four trials indicated that ginseng significantly improved sexual function, they didn’t report any treatment effect compared to the placebo group. Based on the results of meta-analysis obtained from five studies including 531 women, there was no statistically significant effect of ginseng on female sexual dysfunction (FSD) compared to the placebo control group (SMD: 0.26; 95% CI: -0.26 to 0.76). Nonetheless, there was a considerable heterogeneity among the studies (I2 = 81%; P < 0.0001). Moreover, all the included studies assessed adverse events, but in three of the RCTs, there was no significant difference between the placebo and ginseng groups. Conclusions: The evidence regarding ginseng as a therapeutic agent for sexual dysfunction is unjustifiable. Rigorous studies seem warranted in this respect.

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“…However, to the best of our knowledge, only one study has examined the effects of traditional Japanese medicine on body weight gain in a patient with chronic obstructive pulmonary disease (COPD) (3). Ginseng is one of the most well-known herbal medicines and has been administered to patients with chronic wasting diseases (4). Ninjinyoueito, is a Kampo medicine which is comprised of twelve herbs including ginseng and is used to treat various symptoms, such as fatigue, anorexia, night sweats, cough, malaise, insomnia, dry skin and dry mouth (5,6).…”

Section: Introductionmentioning

confidence: 99%

Long‑term maintenance of nutritional status with ninjinyoueito in terminal patients with chronic respiratory disease: Two case reports

et al. 2019

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Ninjinyoeito, is a traditional herbal (Kampo) medicine which is administered to patients with debilitating diseases in NorthEast Asia. Ninjinyoeito has been reported to be effective against loss of physical strength, fatigue and loss of appetite in patients with wasting diseases. The present study described long-term maintenance of body weight with ninjinyoueito in 2 terminal patients with chronic respiratory diseases. The first patient was a 75-year-old with chronic obstructive pulmonary disease (COPD) who took ninjinyoueito for ≥5 years and the second patient was a 72-year-old man with metastatic lung cancer with combined pulmonary fibrosis and emphysema (CPFE) who took ninjinyoueito for ≥1 year. Both of them maintained their physique and nutritional status during the terminal stages of disease and there were no adverse effects observed in these 2 patients which could be attributed to ninjinyoueito. The results suggest that ninjinyoueito may be a supplementary treatment for the maintenance of nutritional status in patients with a chronic respiratory disease accompanied by wasting, such as COPD.

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Ginseng as a Treatment for Fatigue: A Systematic Review

Cited by 86 publications

References 22 publications

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

A Meta-Analysis of the Efficacy of Panax Ginseng on Menopausal Women’s Sexual Function

Long‑term maintenance of nutritional status with ninjinyoueito in terminal patients with chronic respiratory disease: Two case reports

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